Neuroinflammation, Neuronal IL-1R1, and Behavior

神经炎症、神经元 IL-1R1 和行为

基本信息

批准号：
10373034
负责人：
Ning Quan
金额：
$ 34.22万
依托单位：
FLORIDA ATLANTIC UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-04-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10373034
关键词：
Acute Brain Injuries Adhesions Aging Anatomy Animal Model Atlases Behavior Behavioral Binding Brain CNS autoimmune disease Cells Central Nervous System Diseases Chronic Data Development Disease Epilepsy Etiology Genetic Polymorphism Genetic Predisposition to Disease Glutamates Hippocampus (Brain)Human Genetics Impaired cognition Inflammatory Interleukin-1 Interleukin-1 Receptors Knock-in Knock-in Mouse Label Light Link LoxP-flanked allele Maps Mediating Memory impairment Mental disorders Methods Microscopy Modeling Molecular Mood Disorders Mus Nervous system structure Neurodegenerative Disorders Neurologic Neurons Neurotransmitters Pathogenesis Pathology Pathway interactions Predisposition Protein Tyrosine Phosphatase Reporter Role Short-Term Memory Signal Pathway Signal Transduction Stress Synapses System Tracer Withdrawal behavioral study cell type comorbidity cytokine design fighting mRNA Expression neuroinflammation neuropathology neuroregulation novel prevent protein expression psychologic receptive field receptor receptor expression response single cell sequencing social synaptogenesis

项目摘要

Project Summary Neuroinflammation is a significant contributor to most CNS disorders including neurodegenerative diseases and psychological disorders. A hallmark of neuroinflammation is the increased expression of the proinflammatory cytokine interleukin-1 (IL-1) in the brain. How IL-1 causes neuro- and psycho- pathologies is poorly understood. We have recently discovered that the receptor for IL-1, IL-1R1, is expressed in specific sets of neurons in the brain. These neuronal IL-1R1s, nIL-1R1, modulate neuronal activity via non-canonical signaling pathways to alter neuronal function and circuit connectivity. This application is designed to: 1) map nIL-1R1 distribution in the brain, 2)demonstrate the involvement of nIL-1R1 in neuroinflammation induced behavioral deficits and neuropathology, and 3) elucidate the mechanisms of nIL-1R1 mediated neuromodulation.

项目概要神经炎症是大多数中枢神经系统疾病（包括神经退行性疾病）的重要诱因疾病和心理障碍。神经炎症的一个标志是大脑中的促炎细胞因子白介素-1 (IL-1)。 IL-1 如何引起神经和精神疾病人们对病理学知之甚少。我们最近发现IL-1的受体IL-1R1是在大脑中特定的神经元组中表达。这些神经元 IL-1R1、nIL-1R1 调节神经元通过非规范信号传导途径改变神经元功能和电路连接的活动。这应用程序旨在：1) 绘制 nIL-1R1 在大脑中的分布图，2) 展示 nIL-1R1 在神经炎症诱导的行为缺陷和神经病理学中的作用，以及 3) 阐明 nIL-1R1 介导的神经调节机制。