UF PASS: Regulation of exercise transducers: supplement for diverse students

UF PASS：运动传感器的调节：针对不同学生的补充

• 批准号: 10372539
• 负责人: Karyn A Esser
• 金额: $ 3.46万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-15 至 2022-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10372539
• 关键词: Administrative Supplement; Age; Age-Months; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease pathology; Area; Attenuated; Award; Blood; Brain; Brain Pathology; Cognitive deficits; Collection; Data; Doctor of Philosophy; Environment; Exercise; Female; Fiber; Florida; Frontotemporal Dementia; Health; Histologic; Human; Individual; Infrastructure; Injections; Link; Maps; Measures; Medicine; Mentors; Mentorship; Metabolism; Mission; Mitochondria; Modeling; Molecular; Molecular Target; Multiomic Data; Mus; Muscle; Muscle Fibers; Muscle function; Nerve Degeneration; Outcome; Parents; Pathology; Pathway interactions; Phenotype; Physical activity; Physiology; Population Heterogeneity; Positioning Attribute; Protocols documentation; Regulation; Research; Research Training; Resources; Running; Science; Scientist; Series; Skeletal Muscle; Students; Study models; Tauopathies; Testing; Tissues; Training; Training Activity; Transducers; United States National Institutes of Health; Universities; VO2max; Work; base; brain health; brain tissue; career; career development; college; doctoral student; exercise intervention; exercise training; experience; experimental study; functional genomics; graduate student; inflammatory marker; male; meetings; molecular site; mouse model; multidisciplinary; multiple omics; mutant; novel; parent project; power analysis; preclinical study; programs; sex; skeletal muscle weakness; skills; tau Proteins; treadmill; treadmill training

Abstract: The purpose of this Research Supplement is to Promote Diversity in Health-Related Research through support of the career development training for Bryan Alava, a current PhD student at the University of Florida. This administrative supplement will facilitate career development for the candidate and as well as contribute to the mission of the parent project - to discover novel exercise induced health related outcomes. The parent award is part of the MoTrPAC consortium that combines well defined exercise interventions with multi-omics analysis to develop a map of molecular transducers that link exercise to systemic health. To date, the consortium is analyzing the multi-omics data across 17 different tissues collected following a defined treadmill exercise paradigm as part of the preclinical studies. The primary objectives of Mr. Alava’s proposed research are two-fold: First to use a defined Alzheimer’s Disease (AD) mouse model to characterize changes in skeletal muscle function and blood markers of inflammation and metabolism. Second, once characterized we will use this model to test a treadmill training protocol, based on the protocol used for MoTrPAC, for efficacy in delaying the progression of AD. We will also be in a position to access the larger multiomics data available from MoTrPAC to expand potential molecular targets of exercise and AD pathology. Dr. Esser, the PI of the U01, will be one of two primary mentors for Mr. Alava. Dr. Jose Abisambra is the other co-mentor as his lab provides the AD mouse model and expertise in the analysis of brain pathologies. Drs. Esser and Abisambra are already official co-mentors for Bryan Alava within the Ph.D. program in the Department of Physiology and Functional Genomics within the College of Medicine at the University of Florida. We have outlined a series of didactic and experiential training activities that will equip Mr. Alava with the necessary skills to progress as an independent scientist and to fulfill the NIH mission to advance the careers of a diverse population of scientists.

摘要：本研究增刊的目的是促进健康相关研究的多样性 通过支持 Bryan Alava 的职业发展培训，他是该大学的现任博士生 佛罗里达大学。该行政补充将促进候选人的职业发展。 并为父项目的使命做出贡献——发现新的运动诱发健康 家长奖是 MoTrPAC 联盟的一部分，该联盟结合了明确的成果。 通过多组学分析进行干预，以开发链接的分子传感器图谱 迄今为止，该联盟正在分析 17 个不同领域的多组学数据。 作为临床前研究的一部分，按照定义的跑步机运动范例收集的组织。 Alava 先生提出的研究的主要目标有两个：首先使用已定义的阿尔茨海默病 疾病（AD）小鼠模型，用于表征骨骼肌功能和血液标志物的变化 其次，一旦确定了特征，我们将使用该模型来测试跑步机。 训练方案，基于 MoTrPAC 使用的方案，可有效延缓病情进展 AD 我们还将能够访问 MoTrPAC 提供的更大的多组学数据来扩展。 U01 的首席研究员 Esser 博士将是运动和 AD 病理学的两个潜在分子目标之一。 Alava 先生的主要导师是 Jose Abisambra 博士，他的实验室提供 AD。 Esser 和 Abisambra 博士已经拥有小鼠模型和分析专业知识。 布莱恩·阿拉瓦 (Bryan Alava) 生理学系博士项目的官方联合导师 我们概述了佛罗里达大学医学院的功能基因组学。 一系列的教学和体验式培训活动将使阿拉瓦先生具备必要的技能 作为一名独立科学家取得进步，并履行 NIH 的使命，促进多元化的职业生涯 科学家群体。