Molecular Transducers of Physical Activity Consortium Coordinating Center

体力活动分子传感器联盟协调中心

• 批准号: 10840609
• 负责人: Karyn A Esser
• 金额: $ 310万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10840609
• 关键词: Acute; Adherence; Ancillary Study; Animals; Attention; Award; Bioinformatics; Biological; Biological Process; Biological Specimen Banks; Certification; Chemicals; Chronic; Clinic; Clinical Data; Clinical Distribution; Clinical Management; Clinical Trials Data Monitoring Committees; Collaborations; Collection; Communication; Communities; Data; Development; Disease Outcome; Documentation; Ensure; Exercise; Florida; Fostering; Funding; Future; Goals; Health; Health Benefit; Health system; Human Resources; Information Technology; Institutional Review Boards; Intervention; Knowledge; Lead; Leadership; Manuals; Maps; Measures; Molecular; Monitor; Multi-Institutional Clinical Trial; Multi-site clinical study; Online Systems; Organization and Administration; Pathway interactions; Patient Recruitments; Phenotype; Physical activity; Procedures; Process; Progress Reports; Protocols documentation; Public Health; Publications; Publishing; Qualifying; Quality Control; Randomized; Recording of previous events; Reporting; Reproducibility; Research; Research Design; Research Personnel; Resource Sharing; Resources; Safety; Sampling; Schedule; Science; Shipping; Site; Site Visit; Standardization; Structure; Technology; Time; Tissues; Training; Transducers; United States National Institutes of Health; Universities; Vermont; analytical method; biological systems; clinical center; clinical research site; data management; data sharing; design; development policy; endurance exercise; exercise intervention; exercise training; experience; forest; improved; innovation; medical schools; meetings; multidisciplinary; multiple omics; participant retention; phenotypic data; pre-clinical; recruit; resistance exercise; response; success; synergism; tool; working group

Project Summary The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to discover the molecular transducers of endurance and resistance exercise. The Consortium Coordinating Center (CCC), composed of the Administrative Coordinating Core (ACC), the Biospecimens Repository Core (BRC), the Exercise Intervention Core (EIC), and the Data Management, Analysis and Quality Control (DMAQC) Core provides expertise, personnel, and information technology (IT) solutions to support the organization, administration, planning, standardization, documentation, monitoring, analysis, and reporting of all MoTrPAC activities. These functions require working closely with the Clinical Sites, the Preclinical Animal Study Sites (PASS), Ancillary Studies, the Bioinformatics Center (BIC), the Chemical Analysis Sites (CAS), as well as subcommittees and working groups (WGs). The CCC has developed strategies and processes designed to integrate activities of MoTrPAC investigators with the input provided by the Data and Safety Monitoring Board (DSMB), outside experts, and the National Institutes of Health (NIH). The CCC is led by four highly qualified PIs including Dr. Miller at Wake Forest University School of Medicine (WFUSM) who leads the DMAQC Core and manages clinical data and safety-related activities, Dr. Tracy at the University of Vermont (UVM) who vice- chairs the MoTrPAC Steering Committee (SC) and leads the BRC, Dr. Rejeski who resides on the academic campus of Wake Forest University and leads the EIC, and Dr. Esser who leads the ACC at the University of Florida and oversees an administrative staff that is the core for managing Consortium-wide communications, setting-up annual meetings, and supporting subcommittees and WGs. WFUSM is the hub of the CCC, with the DMAQC Core staff providing project management, computing, and analytical support for all other components of the CCC. The EIC also assists the DMAQC Core with safety-related activities and is highly integrated with project managers within the DMAQC Core for supporting clinic-related functions such as Manuals of Procedures (MOPs), phenotypic measures, certification of interventionists and assessors, and site visits. The CCC will continue to employ innovative project management tools, programming, and web-based tracking of recruitment and retention (R&R), interventions, and assessments in real-time. We will capitalize on the outstanding track record in successfully coordinating, managing, and leading large long-term multicenter clinical trials involving exercise and other interventions to accomplish the following: (a) facilitate team science; (b) implement rigor, reproducibility, and transparency in research; (d) acquire, manage, store, and distribute biological samples for analysis; (e) conduct and coordinate preclinical exercise studies; (f) share resources; (g) publish results; and (h) lead multidisciplinary teams to implement best-practices for analytical methods applied to randomized studies. The CCC will facilitate the continued success of MoTrPAC in advancing knowledge regarding the molecular transducers of exercise as related to public health.

项目概要 体力活动分子传感器联盟 (MoTrPAC) 的成立是为了发现 耐力和抗阻运动的分子传感器。联盟协调中心（CCC）， 由行政协调核心（ACC）、生物样本库核心（BRC）、 运动干预核心 (EIC) 和数据管理、分析和质量控制 (DMAQC) 核心 提供专业知识、人员和信息技术 (IT) 解决方案来支持组织， 所有 MoTrPAC 的管理、规划、标准化、记录、监控、分析和报告 活动。这些职能需要与临床中心、临床前动物研究中心密切合作 (PASS)、辅助研究、生物信息学中心 (BIC)、化学分析中心 (CAS) 以及 小组委员会和工作组 (WG)。 CCC 制定了战略和流程，旨在 将 MoTrPAC 调查人员的活动与数据和安全监测委员会提供的意见结合起来 (DSMB)、外部专家和美国国立卫生研究院 (NIH)。 CCC 由四位高素质人士领导 PI 包括领导 DMAQC 核心的维克森林大学医学院 (WFUSM) 的 Miller 博士 佛蒙特大学 (UVM) 的 Tracy 博士负责管理临床数据和安全相关活动，她是 Rejeski 博士担任 MoTrPAC 指导委员会 (SC) 主席并领导 BRC，他是学术界的常驻人员 维克森林大学校园并领导 EIC，Esser 博士领导维克森林大学的 ACC 佛罗里达州并监督管理人员，这是管理联盟范围通信的核心， 设立年度会议，并支持小组委员会和工作组。 WFUSM 是 CCC 的枢纽， DMAQC 核心人员为所有其他组件提供项目管理、计算和分析支持 CCC 的。 EIC 还协助 DMAQC 核心开展安全相关活动，并与 DMAQC 核心内的项目经理，用于支持临床相关功能，例如手册 程序 (MOP)、表型测量、干预人员和评估人员的认证以及实地考察。这 CCC 将继续采用创新的项目管理工具、编程和基于网络的跟踪 实时招募和保留 (R&R)、干预和评估。我们将利用 在成功协调、管理和领导大型长期多中心方面拥有出色的记录 涉及锻炼和其他干预措施的临床试验，以实现以下目标： (a) 促进团队科学； (b) 实现研究的严谨性、可重复性和透明度； (d) 获取、管理、存储和分发 用于分析的生物样品； (e) 进行和协调临床前运动研究； (f) 共享资源； （克） 公布结果； (h) 领导多学科团队实施所应用分析方法的最佳实践 进行随机研究。 CCC 将促进 MoTrPAC 在推进知识方面不断取得成功 关于运动的分子传感器与公共卫生的关系。