Renovation of Core Laboratories for the DC Intellectual and Developmental Disabilities Research Center

华盛顿特区智力与发育障碍研究中心核心实验室改造

• 批准号: 10374284
• 负责人: Vittorio Gallo
• 金额: $ 674.91万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2023-05-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10374284
• 关键词: Bioinformatics; Budgets; Cells; Cerebral Palsy; Child; Core Facility; Developmental Disabilities; District of Columbia; Epilepsy; Floor; Funding; Genetic Research; Genomics; Hospitals; Inherited; Institutes; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Laboratories; Medical center; Metabolic Diseases; Microscopy; Mission; Modernization; Neurosciences Research; Pathology; Research; Research Personnel; Site; Tissues; United States National Institutes of Health; Universities; Washington; autism spectrum disorder; cost; improved; induced pluripotent stem cell; innovation; inter-institutional; programs; research facility

Project Summary Children’s National Hospital (CNH) proposes to relocate 15,520 GSF of advanced core facility research space in support of its NIH funded District of Columbia Intellectual and Developmental Disabilities Research Center (DC- IDDRC). The relocation and expansion of this program will be from CNH Sheikh Zayed campus to the new Children’s National Research and Innovation Campus located at the former Walter Reed Army Medical Center site in Northwest Washington, D.C., 4 miles from the hospital. The project involves renovation/modernization of one floor of the former Armed Forces Institute of Pathology building originally constructed in 1955. The total cost of this construction is estimated to be $9,446,951. This CO6 requests a budget of $8,000,000 with the remainder of the cost (approximately $1,446,951) being funded by CNH. This state-of-the-art core facility will allow the conduct and expansion of genetic and neuroscience research initiatives of the DC-IDDRC, an interdisciplinary and inter-institutional research center. The mission of this IDDRC is to improve the understanding and treatment of children with developmental disabilities, including autism, cerebral palsy, epilepsy, inherited metabolic disorders and intellectual disability. The new space will support 3 cores that will be accessible to investigators from the four institutions that comprise the DC-IDDRC: CNH, George Washington University (GW), Georgetown University and Howard University. The construction will also include shared hoteling laboratory space for DC-IDDRC investigators whose laboratories are not on- site but who are utilizing the core facility. The proposed DC-IDDRC cores consist of: 1) Cell and Tissue Microscopy, 2) Genomics and Bioinformatics, and 3) Induced Pluripotent Stem Cells (IPSC).

项目概要 国立儿童医院 (CNH) 提议迁移 15,520 GSF 的先进核心设施研究空间 支持 NIH 资助的哥伦比亚特区智力和发育障碍研究中心 (DC-IDDRC) 该计划将从 CNH Sheikh Zayed 校区搬迁和扩展至 新的儿童国家研究与创新园区位于前沃尔特·里德陆军医疗中心 中心站点位于华盛顿特区西北部，距离医院 4 英里。 原武装部队病理研究所大楼一层的翻修/现代化 建于 1955 年。该建筑的总成本估计为 9,446,951 美元。 预算为 8,000,000 美元，其余费用（约 1,446,951 美元）由 CNH 资助。 最先进的核心设施将允许进行和扩展遗传和神经科学研究 DC-IDDRC 是一个跨学科、跨机构的研究中心，其倡议的使命。 IDDRC 旨在提高对发育障碍儿童的理解和治疗，包括 自闭症、脑瘫、癫痫、遗传性代谢紊乱和智力障碍将成为新的空间。 支持组成 DC-IDDRC 的四个机构的调查人员可以使用的 3 个核心： CNH、乔治华盛顿大学 (GW)、乔治城大学和霍华德大学。 还将包括为 DC-IDDRC 调查员提供共享的酒店实验室空间，这些调查员的实验室不在 站点但正在使用核心设施的人员 拟议的 DC-IDDRC 核心包括： 1) 细胞和组织。 显微镜，2) 基因组学和生物信息学，以及 3) 诱导多能干细胞 (IPSC)。