Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

父母自杀行为史对童年中后期的影响：自杀风险早期标记的纵向评估

• 批准号: 10366565
• 负责人: Arielle Hope Sheftall
• 金额: $ 45.88万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10366565
• 关键词: Adolescence; Adolescent; Age; Age of Onset; Arousal; Arousal and Regulatory Systems; Behavioral; Biological; Black race; Cause of Death; Child; Childhood; Development; Emergency department visit; Emotional; Enrollment; Family; Feeling suicidal; Female; Frustration; Functional disorder; Future; Goals; Intervention; Interview; Knowledge; Learning; Measures; Mediating; Mediator of activation protein; Mental Health; Methods; National Institute of Mental Health; Neurocognitive; Neurocognitive Deficit; Parents; Participant; Patient Self-Report; Population Heterogeneity; Positive Valence; Prevention; Prevention strategy; Primary Prevention; Public Health; Race; Recording of previous events; Regulation; Research; Research Domain Criteria; Research Priority; Rewards; Risk; Risk Factors; Role; Sampling; Social Processes; Strategic Planning; Suicide; Suicide attempt; System; Techniques; Testing; Visit; Youth; age group; age related; aged; attentional control; black men; black women; cognitive control; cognitive system; cohort; computerized; early onset; emotion dysregulation; experience; externalizing behavior; high risk; high risk population; male; non-suicidal self injury; offspring; peer; prevent; racial disparity; recruit; sex; sex disparity; social communication; suicidal adolescent; suicidal behavior; suicidal risk; suicide rate; transmission process; trend

PROJECT SUMMARY/ABSTRACT Suicide is the fifth leading cause of death among U.S. children 5 to 12 years, yet limited research on childhood suicide and suicidal behavior (SB) exists. The National Institute of Mental Health (NIMH) has acknowledged this critical gap as a high research priority. A significant risk factor for the early onset of a first suicide attempt (SA) is a parental history of SB. Although the familial transmission of SB is well documented, research examining the specific mechanisms associated with familial risk is limited. Our ongoing NIMH-R21 study (Cohort 1) is investigating factors related to the familial risk of SB in children, 6-9 years, with (PH+; n=100) and without (PH-; n=100) a parental history of SA. This proposed R01 study will continue annual follow-ups for Cohort 1 and add an additional 300 newly enrolled families (Cohort 2; ages 9-11 years; 150 per PH group) for a total sample of 500 parent-child dyads. Youth will be followed for four years from mid/late-childhood through early/mid-adolescence. Using the Research Domain Criteria (RDoC) framework, we will examine the trajectories of neurocognitive function (NF), emotional reactivity/regulation (ERR), non-suicidal self-injury (NSSI), suicidal ideation (SI), and SA in PH+ and PH- youth along with contributions by sex and race. Study participants at first assessment include youth 7-12 years. At last assessment, youth ages will range from 10-15 years. Both groups, PH+ and PH-, will be balanced by sex and race. Two main research aims and one exploratory aim will be tested. Aim 1: Examine longitudinally how PH status is associated with trajectories of NF and ERR constructs measured during mid/late-childhood through early/mid-adolescence. Aim 2: Investigate the potential mediating role of NF and ERR constructs on the association between PH status and offspring NSSI, SI, and SA. Exploratory Aim: Test sex and race as potential moderators of ERR and NF trajectories, and on the association between PH status and offspring NSSI, SI, and SA. This proposal’s central hypotheses are that (1) PH+ status increases vulnerability for developmental trajectories characterized by NF deficits and emotional dysfunction/dysregulation; (2) these trajectories will mediate the association between PH status and youth NSSI, SI, and SA; and (3) these associations between trajectories and SB/NSSI will be moderated by both sex and race. The hypotheses are informed by preliminary findings from the ongoing NIMH- R21 study, where group differences were found for ERR, SB, and NF. The proposed R01 study aligns well with the NIMH 2020 Strategic Plan for Research with emphasis on Goal 2-investigating mental health trajectories and inclusion of diverse samples. Completing the proposed study will assist with the identification of specific mechanisms associated with the familial risk of SB, determine if sex and race moderate the associations between risks and youth SB, and provide direction for targeted prevention strategies for high-risk youth.

项目概要/摘要 自杀是美国 5 至 12 岁儿童的第五大死因，但对儿童的研究有限 美国国家心理健康研究所 (NIMH) 已承认存在自杀和自杀行为 (SB)。 这一关键差距是首次自杀未遂早期发生的一个重要风险因素。 (SA) 是 SB 的父母史，尽管 SB 的家族传播已有充分记录，但研究表明。 我们正在进行的 NIMH-R21 研究对与家族风险相关的具体机制进行了有限的研究。 （队列 1）正在调查与 6-9 岁儿童 SB 家族风险相关的因素，其中（PH+；n=100）和 没有（PH-；n=100）父母有 SA 病史的 R01 研究将继续每年进行随访。 队列 1 并添加另外 300 个新注册家庭（队列 2；年龄 9-11 岁；每个 PH 组 150 个） 总共对 500 名亲子青少年进行了为期四年的跟踪调查，从童年中期/晚期到童年后期。 使用研究领域标准（RDoC）框架，我们将检查青春期早期/中期。 神经认知功能（NF）、情绪反应/调节（ERR）、非自杀性自残的轨迹 (NSSI)、自杀意念 (SI) 和 PH+ 和 PH- 青少年的 SA 以及性别和种族研究的贡献。 第一次评估的参与者包括 7-12 岁的青少年，最后一次评估的青少年年龄范围为 10-15 岁。 PH+ 和 PH- 这两个群体将按性别和种族进行平衡，有两个主要研究目标和一个。 将测试探索性目标 目标 1：纵向检查 PH 状态与轨迹的关系。 在童年中期/晚期到青春期早期/中期测量 NF 和 ERR 结构。目标 2： 研究 NF 和 ERR 结构对 PH 状态和 PH 状态之间关联的潜在中介作用 后代 NSSI、SI 和 SA 探索性目标：测试性别和种族作为 ERR 和 NF 的潜在调节因素。 轨迹，以及 PH 状态与后代 NSSI、SI 和 SA 之间的关联。 假设 (1) PH+ 状态会增加以 NF 为特征的发育轨迹的脆弱性 缺陷和情绪功能障碍/失调；（2）这些轨迹将介导 PH 之间的关联。 状态和青年 NSSI、SI 和 SA；以及 (3) 轨迹和 SB/NSSI 之间的这些关联 这些假设是根据正在进行的 NIMH- 的初步调查结果得出的。 R21 研究，发现 ERR、SB 和 NF 存在组间差异。拟议的 R01 研究与该研究非常吻合。 NIMH 2020 年研究战略计划，重点是目标 2——调查心理健康轨迹 完成拟议的研究将有助于识别特定的样本。 与 SB 家族风险相关的机制，确定性别和种族是否调节这种关联 风险与青少年SB之间的关系，并为高危青少年的针对性预防策略提供指导。