CHILDHOOD SEXUAL ABUSE AND PROBLEM DRINKING IN WOMEN: NEUROBEHAVIORAL MECHANISMS

女性儿童期性虐待和饮酒问题：神经行为机制

• 批准号: 10330953
• 负责人: Andrey P. Anokhin
• 金额: $ 52.97万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-02-10 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10330953
• 关键词: Acoustics; Address; Affect; Affective; Alcohol abuse; Alcoholism; Alcohols; Attention; Attenuated; Behavioral; Behavioral Paradigm; Brain; Characteristics; Child Sexual Abuse; Cognitive; Confounding Factors (Epidemiology); Control Groups; Cues; Data; Development; Dimensions; Electroencephalography; Emotional; Etiology; Event-Related Potentials; Exhibits; Exposure to; Family; Family history of; Feedback; Functional disorder; Goals; Heavy Drinking; Image; Informal Social Control; Intervention; Interview; Knowledge; Laboratories; Lead; Learning; Link; Literature; Measures; Mediating; Methodology; Modeling; Motivation; Outcome; P300 Event-Related Potentials; Pathway interactions; Performance; Personality; Personality Traits; Pharmaceutical Preparations; Positive Valence; Predisposition; Prevention; Process; Psychological reinforcement; Psychopathology; Psychophysiology; Punishment; Recording of previous events; Reflex action; Reporting; Research; Research Personnel; Resources; Rewards; Risk; Sampling; Siblings; Stimulus; Stress; Substance abuse problem; Symptoms; Temperament; Testing; Twin Multiple Birth; Woman; addiction; alcohol cue; alcohol misuse; alcohol response; alcohol risk; alcohol use disorder; attenuation; behavior test; binge drinking; cognitive control; cognitive testing; coping; cue reactivity; design; drinking; early childhood; early onset; executive function; experience; girls; member; negative affect; neurobehavioral; neurophysiology; novel; relating to nervous system; response; substance use; theories; therapy development; young adult

Abstract (Project Summary) The overall goal of the proposed project is to elucidate neurobehavioral mechanisms underlying the relationships between a history of childhood sexual abuse (CSA) and alcohol and other substance use outcomes in women. Women with CSA history have earlier onset of alcohol misuse and higher rates of alcohol use disorders, even after controlling for family background factors influencing both CSA exposure and problem drinking, such as family history of alcoholism. Converging evidence suggests that CSA and its consequences for brain development may constitute a distinct etiological pathway to alcoholism in women. However, neural, cognitive, affective, and behavioral processes and mechanisms underlying the link between CSA and alcohol abuse are not well understood. Existing research on neurobehavioral consequences of CSA have typically relied on small samples and insufficiently matched control groups limiting control for family-level confounding factors and causal inferences. The proposed study seeks to address these gaps in knowledge and methodological challenges by utilizing a unique resource consisting of several large, well-characterized, longitudinal samples and implementing a model-driven set of experimental paradigms to test the hypothesis that problem drinking in CSA+ women is mediated by biased affective processing and dysfunction in cognitive control, leading to dysregulated affect and, consequently, coping motives for drinking. The proposed studies are strongly grounded in the current theories of addiction and supported by preliminary findings from our laboratory. Young adult women with a history of early CSA (n=80) and propensity score-matched controls (n=120, including 40 CSA- co-twins from CSA-discordant MZ twin pairs) will participate in a laboratory session involving face-to-face interviews, behavioral and cognitive testing, and the recording of quantitative EEG and ERPs in several behavioral paradigms. The following Specific Aims will be pursued: 1) to elucidate behavioral and psychophysiological mechanisms underlying the relationship between CSA, alcohol, and other substance use outcomes in women, 2) to examine alcohol cue reactivity (ACR) in CSA+ and CSA- women and its relationship with drinking motives and problem drinking, and 3) to determine whether observed differences associated with CSA represent consequences of abuse rather than pre-existing vulnerabilities by using the cotwin control design. In summary, the proposed project is aimed at bridging important gaps in knowledge and will be one of the first well-powered and well-controlled inquiries into the neurobehavioral pathways and mechanisms underlying an important etiological pathway to alcoholism in women. Several aspects of the proposed research are particularly novel: the use of propensity score matching and discordant twin analyses to control for potential confounding variables, focus on a specific etiological pathway to alcoholism in women; and explication of neurobehavioral mechanisms underlying the link between CSA and alcohol problems.

摘要（项目概要） 该项目的总体目标是阐明神经行为机制 儿童性虐待史 (CSA) 与酒精和其他物质使用之间的关系 对女性的结果。有 CSA 病史的女性酗酒较早，饮酒率较高 使用障碍，即使在控制了影响 CSA 暴露和问题的家庭背景因素之后 饮酒，例如有酗酒家族史。综合证据表明 CSA 及其后果 大脑发育可能构成女性酗酒的独特病因途径。然而，神经， CSA 与酒精之间联系的认知、情感和行为过程和机制 滥用行为尚未得到很好的理解。现有关于 CSA 神经行为后果的研究通常 依赖于小样本和不充分匹配的对照组，限制了对家庭层面混杂因素的控制 因素和因果推论。拟议的研究旨在解决这些知识和技术方面的差距 通过利用由几个大型的、特征良好的、 纵向样本并实施一组模型驱动的实验范式来检验假设 CSA+ 女性的饮酒问题是由情感处理偏差和认知功能障碍介导的 控制，导致情绪失调，从而导致应对饮酒的动机。拟议的研究 强烈扎根于当前的成瘾理论，并得到我们的初步研究结果的支持 实验室。有早期 CSA 病史的年轻成年女性 (n=80) 和倾向评分匹配对照 （n = 120，包括来自 CSA 不一致同卵双胞胎的 40 名 CSA 同卵双胞胎）将参加实验室会议 包括面对面访谈、行为和认知测试以及定量脑电图和记录 几种行为范式中的 ERP。将追求以下具体目标： 1) 阐明行为 CSA、酒精和其他物质之间关系的心理生理机制 使用女性结果，2) 检查 CSA+ 和 CSA- 女性的酒精提示反应性 (ACR) 及其 与饮酒动机和问题饮酒的关系，以及 3) 确定是否观察到差异 与 CSA 相关的漏洞代表了滥用的后果，而不是通过使用预先存在的漏洞 cotwin控制设计。总之，拟议项目旨在弥合知识和知识方面的重要差距 将是第一个对神经行为途径进行有力且控制良好的调查之一 女性酗酒重要病因途径的机制。几个方面 拟议的研究特别新颖：使用倾向得分匹配和不一致双胞胎分析来 控制潜在的混杂变量，重点关注女性酗酒的具体病因途径；和 解释 CSA 和酒精问题之间联系的神经行为机制。