An integrated vascular MR imaging suite in brain diseases

脑部疾病的综合血管 MR 成像套件

• 批准号: 10330590
• 负责人: Hanzhang Lu
• 金额: $ 56.22万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10330590
• 关键词: Acetazolamide; Algorithms; Allergic; Blood; Blood Vessels; Bolus Infusion; Brain; Brain Diseases; Brain Neoplasms; Bypass; Carbon Dioxide; Categories; Cerebrovascular Circulation; Cerebrovascular Disorders; Cerebrovascular system; Clinical; Collection; Contrast Media; Cross-Sectional Studies; Data; Data Set; Development; Diagnosis; Diamox; Disease; Functional Magnetic Resonance Imaging; Future; Gadolinium DTPA; Gases; Glomerular Filtration Rate; Goals; Image; Inhalation; Injections; Magnetic Resonance Imaging; Maps; Measurement; Measures; Medical Imaging; Methods; Microvascular Dysfunction; Monitor; Moyamoya Disease; Neurologic; Neurophysiology - biologic function; Neurosurgeon; Operative Surgical Procedures; Outcome; Participant; Patients; Performance; Perfusion; Pharmaceutical Preparations; Physiologic pulse; Physiological; Play; Positron-Emission Tomography; Procedures; Property; Radioactive; Radioisotopes; Reproducibility; Resolution; Rest; Role; Scanning; Standardization; Stenosis; Stratification; Stress Tests; Stroke; Symptoms; System; Techniques; Technology; Time; Traumatic Brain Injury; Validation; Vascular Dementia; Vendor; Visit; Work; automated analysis; base; biomaterial compatibility; care costs; cerebral blood volume; cerebrovascular; cerebrovascular health; cerebrovascular imaging; clinical imaging; clinical practice; cloud based; computational platform; computerized data processing; hemodynamics; imaging modality; indexing; interest; nervous system disorder; neurosurgery; novel; novel strategies; predict clinical outcome; research study; single photon emission computed tomography; spatiotemporal; tool; web site

Project Summary/Abstract: Cerebrovascular imaging has a broad impact in a variety of brain disorders, including cerebrovascular diseases such as stroke, arterial stenosis, Moymoya disease, small vessel diseases, and vascular dementia, but also in other neurological conditions such as brain tumor and traumatic brain injury. Current clinical practice of cerebrovascular imaging requires multiple scans and, in some cases, multiple visits in order to obtain a complete assessment of the brain’s vascular health that includes perfusion, hemodynamic parameter, and flow reserve. This limitation increases patient burden and significantly escalates the cost of care. Therefore, the goal of the present project is to develop novel methods to perform an integrated vascular (iVas) imaging that provides all relevant physiological information in a single scan (<10 minutes). The proposed iVas-MRI technique will apply concomitant O2 and CO2 gas inhalation (but with different timing) and will simultaneously measure cerebral blood volume (CBV), cerebrovascular reactivity (CVR), bolus time-to-peak (TTP), and functional connectivity networks from the same dataset. Aim 1 will develop three key components of the iVas-MRI technique, specifically concomitant O2 and CO2 gas-inhalation paradigm, high spatial-resolution MRI pulse sequence, and multi-parametric data processing algorithm. A cloud-based computation platform will also be developed for standardization of the analysis and future dissemination of the technique. Aim 2 will conduct validation and multi-vendor assessment of the iVas-MRI technique. We will compare results of the iVas-MRI technique to those of standard techniques and will examine across-vendor reproducibility of the proposed technique by scanning each participant on three MRI systems manufactured by General Electric, Philips, and Siemens, respectively. Aim 3 will apply the technique in patients with Moyamoya disease and study its potential value in both the diagnosis and treatment monitoring of this condition. We will first examine the utility of iVas-MRI in predicting clinical outcomes in a cross-sectional setting. Then, through serial MRIs, we will examine the utility of iVas-MRI in differentiating treatment benefits of two most commonly performed surgical procedures in Moyamoya patients, specifically direct versus indirect bypass surgery. The long-term impact of this work on clinical practice is that patients with cerebrovascular diseases will have their vascular imaging scan done in just one visit of less than 10 minutes (as opposed to multiple visits and several scans). Additionally, patients who are allergic to conventional contrast agent will have access to an alternative contrast agent (i.e. O2 and CO2 gases) for their vascular imaging needs.

项目摘要/摘要： 脑血管成像对多种脑部疾病具有广泛的影响，包括脑血管疾病 中风、动脉狭窄、烟雾病、小血管疾病和血管性痴呆等疾病， 还适用于其他神经系统疾病，例如脑肿瘤和脑外伤当前的临床实践。 脑血管成像需要多次扫描，在某些情况下，需要多次就诊才能获得 完整评估大脑血管健康状况，包括灌注、血流动力学参数和流量 这种限制显着增加了患者的负担并增加了护理成本。 本项目的目标是开发执行集成血管 (iVas) 成像的新方法 在一次扫描（<10 分钟）中提供所有相关的生理信息。 所提出的 iVas-MRI 技术将同时吸入 O2 和 CO2 气体（但采用不同的方法） 计时）并同时测量脑血量（CBV）、脑血管反应性（CVR）、推注 目标 1 将开发三个密钥。 iVas-MRI 技术的组成部分，特别是伴随 O2 和 CO2 气体吸入范例，高 空间分辨率 MRI 脉冲序列和基于云的多参数数据处理算法。 还将开发计算平台，以实现分析和未来传播的标准化 目标 2 将对 iVas-MRI 技术进行验证和多供应商评估。 将 iVas-MRI 技术的结果与标准技术的结果进行比较，并将检查跨供应商 通过在三个 MRI 系统上扫描每个参与者来验证所提出技术的可重复性 通用电气、飞利浦和西门子将分别将该技术应用于烟雾病患者。 我们将研究其在诊断和治疗监测方面的潜在价值。 首先检查 iVas-MRI 在横断面环境中预测临床结果的效用。 系列 MRI，我们将检查 iVas-MRI 在区分两种最常见的治疗益处方面的效用 在烟雾病患者中进行的外科手术，特别是直接与间接搭桥手术。 这项工作对临床实践的长期影响是，脑血管疾病患者将 只需一次不到 10 分钟的就诊即可完成血管成像扫描（而不是多次就诊） 和多次扫描）此外，对传统造影剂过敏的患者将可以使用造影剂。 满足血管成像需求的替代造影剂（即 O2 和 CO2 气体）。