TRD1: Quantitative Imaging of Physiological Markers

TRD1：生理标志物的定量成像

基本信息

批准号：
10439903
负责人：
Hanzhang Lu
金额：
$ 19.03万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-07-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10439903
关键词：
3-Dimensional Alzheimer&apos s Disease Amyloid Anatomy Area Attention Benchmarking Big Data Biological Markers Biophysics Blood - brain barrier anatomy Blood Pressure Blood Vessels Bolus Infusion Brain Brain Diseases Carbon Dioxide Cerebrovascular Circulation Clinical Clinical Trials Collaborations Data Analyses Dementia Development Diffuse Disease Ensure Extravasation Fingerprint Functional Imaging Functional Magnetic Resonance Imaging Funding Future Gases Glutathione Goals Image Impaired cognition Inhalation Lead Magnetic Resonance Imaging Magnetism Measurement Measures Metabolic Methods Modeling Monitor Multi-Institutional Clinical Trial Multicenter Studies Nature Neurosciences Outcome Measure Oxidative Stress Oxygen Oxygen Consumption Pathology Patient Selection Patients Pharmacologic Substance Phosphocreatine Physiologic pulse Physiological Physiology Positron-Emission Tomography Predisposition Principal Investigator Property Radiology Specialty Readiness Relaxation Reproducibility Research Research Personnel Resources Role Sampling Services Sickle Cell Anemia Signal Transduction Slice Speed Standardization Techniques Technology Testing Time Tissues Treatment outcome United States National Institutes of Health Vascular Dementia Vascular blood supply Vendor anatomic imaging arterial spin labeling blood-brain barrier permeabilization candidate marker cerebrovascular clinical outcome assessment cloud based computerized data processing contrast imaging deep learning density diagnostic biomarker image reconstruction improved interest learning strategy metabolic rate method development novel patient population personalized medicine professor quantitative imaging reconstruction response statistics synergism tau Proteins technique development time use tool treatment effect vascular contributions

项目摘要

TRD 1: Quantitative Imaging of Physiological Markers Lead Principal investigator: Hanzhang Lu, Professor of Radiology Co-investigators: Jim Pekar, Qin Qin, Jun Hua, Peiying Liu, Wenbo Li This TRD will develop physiological MRI techniques that provide quantitative and biologically interpretable measures of the brain. We will develop methods to probe basal physiological parameters including cerebral blood flow (CBF), bolus arrival time (BAT), oxygen extraction fraction (OEF), and blood-brain barrier (BBB) permeability. We will also develop techniques to assess dynamic physiological parameters including cerebrovascular reactivity (CVR), arterial pulsatility, and vascular compliance (VC). We will achieve these goals through systematic development of novel pulse sequences, models, and data processing methods. To allow these sophisticated measures to be obtained with clinically practical time, fast acquisition methods will be integrated into our techniques such as compressed sensing, multi-band/simultaneous-multi-slice, parallel imaging, variable-density spiral sampling, and stack-of-stars 3D acquisition. Multi- contrast imaging (e.g. combining physiological with anatomic imaging) will be achieved by MR Fingerprinting (MRF). To improve the speed and reliability of parametric estimations, especially for MRF-type of acquisitions, deep learning methods will also be applied. To ensure readiness of these techniques for biomarker testing, small-scale standardization and compatibility assessments will be performed which include intra- session, inter-session, inter-vendor, inter-rater test-retest, and cloud-based MRI data processing. The development of the techniques will be conducted with close interactions (so-called “push-pull relationship”) with the Collaborative Projects (CPs) and in collaboration with other TRDs. Additionally, these tools, once fully tested, will be disseminated to the Service Projects (SPs) and other interested researchers.

TRD 1：生理标志物的定量成像首席研究员：陆汉章，放射学教授联合研究员：Jim Pekar、Qin Qing、Jun Hua、Peiying Liu、Wenbo Li 该TRD将开发生理MRI技术，提供定量和我们将开发探测基础的方法。生理参数包括脑血流量（CBF）、推注到达时间（BAT）、氧提取分数（OEF）和血脑屏障（BBB）渗透性。还开发了评估动态生理参数的技术，包括脑血管反应性（CVR）、动脉搏动和血管顺应性（VC）。将通过系统开发新颖的脉冲序列来实现这些目标，模型和数据处理方法。通过临床实践时间获得的快速采集方法将集成到我们的压缩感知、多频带/同时多切片、并行等技术成像、可变密度螺旋采样和星堆栈 3D 采集。将实现对比成像（例如，生理与解剖成像相结合）通过MR指纹（MRF）来提高参数化的速度和可靠性。估计，特别是对于 MRF 类型的收购，深度学习方法也将是为了确保这些技术为小规模生物标志物测试做好准备。将进行标准化和兼容性评估，其中包括内部会话、会话间、供应商间、评估者间重测和基于云的 MRI 数据技术的开发将密切进行。与合作项目（CP）的互动（所谓的“推拉关系”）和此外，这些工具一旦经过全面测试，将与其他 TRD 合作进行测试。分发给服务项目 (SP) 和其他感兴趣的研究人员。