Prenatal cannabis: A fetal neuroimaging study of neurodevelopment

产前大麻：神经发育的胎儿神经影像学研究

基本信息

批准号：
10317882
负责人：
Claudia I Lugo-Candelas
金额：
$ 62.25万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10317882
关键词：
Address Adolescent Affect Alcohols Anxiety Attention deficit hyperactivity disorder Attenuated Autopsy Behavior assessment Behavioral Benign Binding Blood - brain barrier anatomy Brain CNR1 gene Canada Cannabis Child Cigarette Cocaine Cognitive Collaborations Corpus striatum structure Data Development Dopamine Drug usage Enrollment Environment Environmental Risk Factor Executive Dysfunction Exposure to Family Female First Pregnancy Trimester Functional Magnetic Resonance Imaging Future Genetic Health Policy Healthcare Systems High Prevalence Home environment Human Infant Infant Behavior Intervention Laboratories Legal Life Link MRI Scans Magnetic Resonance Imaging Measures Mediating Medical center Minnesota Moods Mothers Nausea Neurons North America Opioid Outcome Parents Patient Self-Report Perinatal Pharmaceutical Preparations Phenotype Placenta Postpartum Period Predisposition Prefrontal Cortex Pregnancy Pregnant Women Prenatal care Prevention Prevention strategy Psychoses Public Health Quebec Recording of previous events Reporting Research Risk Rodent Safety Specificity Stress Structure Substance of Abuse Teenagers Tetrahydrocannabinol Third Pregnancy Trimester Universities Withdrawal Symptom Woman anxiety symptoms base behavior measurement behavioral outcome brain behavior brain research critical period data collection site delivery complications demographics design epidemiology study executive function fetal fetal blood fetal drug exposure fetal marijuana exposure health care availability high risk population human fetal brain hypothalamic-pituitary-adrenal axis impression in utero indexing male marijuana legalization marijuana use marijuana use in pregnancy maternal anxiety maternal depression mesolimbic system migration mood symptom neurodevelopment neurodevelopmental effect neuroimaging novel offspring postnatal pre-clinical premature prenatal prenatal exposure receptor expression relating to nervous system sex substance use synaptogenesis tertiary care tool young adult

项目摘要

PROJECT SUMMARY Current estimates suggest that in North America over 7% of women use cannabis during pregnancy and this use is increasing as legalization becomes more common. Despite the high prevalence of prenatal cannabis exposure, its effects on early brain and behavioral development remain poorly characterized, leaving some with the impression that this exposure is benign or potentially even beneficial (e.g., to treat nausea during pregnancy). Prior neurodevelopmental research on prenatal cannabis effects have had been important limitations including few if any brain/behavioral assessments during first two years of life (a period critical to neurodevelopment), poor characterization of the post-natal environment, and limited assessments of pre- and post-natal maternal mood and anxiety, thus confounding interpretation of prenatal cannabis effects. In our study, we will enroll pregnant women with (n=300) and without a history (n=150) of cannabis use during the first trimester gestation and follow their offspring for the first two years of life with a focus on the neurodevelopment of executive functions. First, we will characterize prenatal cannabis use through pregnancy with self-report measures and biospecimens. Second, we will obtain third trimester fetal MRI scans to character offspring brain structure and function free of post-natal confounds. Third, we will assess offspring cognitive and behavioral development over the first two years of life with parent-report and laboratory-based behavioral assessments. Our design considers critical confounds including parent-infant interactions, pre- and postnatal maternal mood and anxiety symptoms, shared genetic liability, and concomitant drug use during pregnancy. Given the lack of clarity on the safety of cannabis use during pregnancy, findings from this study will have important public health implications by informing prevention messaging and strategies particularly in this era of increasing cannabis use.

项目概要目前的估计表明，在北美，超过 7% 的女性在怀孕期间使用大麻，这随着合法化变得更加普遍，使用量也在增加。尽管产前大麻流行率很高暴露，其对早期大脑和行为发展的影响仍然知之甚少，使一些人这种接触是良性的甚至可能有益的印象（例如，治疗怀孕期间的恶心）。先前关于产前大麻影响的神经发育研究存在重要局限性，包括在生命的头两年（神经发育的关键时期），很少有大脑/行为评估，差产后环境的特征以及对产前和产后母亲情绪的有限评估和焦虑，从而混淆了对产前大麻影响的解释。在我们的研究中，我们将登记孕妇在妊娠前三个月期间有（n = 300）和无大麻使用史（n = 150）的妇女并跟踪他们的后代在生命的前两年，重点关注执行功能的神经发育。第一的，我们将通过自我报告措施和生物样本来描述整个怀孕期间产前大麻使用的特征。其次，我们将获得妊娠晚期胎儿 MRI 扫描，以表征后代的大脑结构和功能，不受干扰。产后混乱。第三，我们将评估前两者的后代认知和行为发展通过家长报告和基于实验室的行为评估来了解生命年数。我们的设计考虑至关重要混杂因素包括父母与婴儿的互动、产前和产后母亲的情绪和焦虑症状，遗传倾向，以及怀孕期间的伴随药物使用。鉴于大麻的安全性尚不明确在怀孕期间使用，这项研究的结果将通过告知人们对公共健康产生重要影响预防信息和策略，特别是在大麻使用日益增加的时代。