A longitudinal study of prenatal maternal obesity and the fetal origins of impulsivity in Puerto Rican children

波多黎各儿童产前肥胖和胎儿冲动起源的纵向研究

• 批准号: 9883841
• 负责人: Claudia I Lugo-Candelas
• 金额: $ 19.75万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883841
• 关键词: 2 year old; Accounting; Age; Animal Experimentation; Attention deficit hyperactivity disorder; Award; Behavior; Behavior assessment; Behavioral; Biometry; Body mass index; Brain; Child; Child Health; Childhood; Collection; Communities; Conceptions; Data; Data Collection; Development; Disease; Dopamine; Enrollment; Ensure; Environment; Epidemiology; Equipment and supply inventories; Ethnic group; Exposure to; Felis catus; Fostering; Functional Magnetic Resonance Imaging; Future; Generations; Goals; Hispanics; Human; Impairment; Impulsivity; Infant; Inflammation; Interleukin-6; Intervention; Life Cycle Stages; Life course epidemiology; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mediator of activation protein; Mental disorders; Mentorship; Monitor; Mothers; National Institute of Mental Health; Newborn Infant; Not Hispanic or Latino; Nursery Schools; Obesity; Outcome Study; Parents; Participant; Perinatal; Physical activity; Plant Roots; Population; Population Heterogeneity; Pregnancy; Pregnant Women; Prevalence; Prevention; Proteins; Puerto Rican; Reporting; Research; Research Personnel; Research Training; Rest; Risk; Role; Sampling; Signal Transduction; Structure; Testing; Third Pregnancy Trimester; Toddler; Training; United States National Institutes of Health; Ventral Striatum; Weight; Woman; Work; Youth; authority; behavior measurement; career development; cohort; disorder control; early childhood; epidemiology study; executive function; experience; fetal; follow up assessment; indexing; infancy; interdisciplinary approach; intergenerational; magnetic resonance imaging biomarker; maternal obesity; neural circuit; neurodevelopment; neuroimaging; nutrition; offspring; phenomenological models; postnatal; prenatal; prenatal exposure; prenatal influence; prepregnancy; programs; prospective; racial and ethnic; racial minority; sex; skills; transmission process

PROJECT SUMMARY This K08 application aims at examining a potential fetal origin of inhibitory control difficulties: in utero exposure to prenatal maternal obesity. This study fills a crucial gap by examining inhibitory control deficits in an intergenerational sample of Puerto Ricans in the US. This community, alongside other Latino populations, has seen an increase in obesity and impulsivity-related disorders such as attention-deficit/hyperactivity disorder (ADHD), yet remains vastly understudied. This five-year K08 application presents a program for research and training that will support the applicant on a path towards becoming an independent investigator, focused on studying the early origins of inhibitory control deficits through an interdisciplinary approach (life course epidemiology, infant neuroimaging, and biostatistics). The training plan builds on the candidate's prior training and experience and capitalizes on an outstanding mentorship team and research environment to foster the development of the candidate's expertise in (1) collection, analysis, and interpretation of infant resting state functional Magnetic Resonance Imaging (fMRI) data; (2) perinatal weight and inflammation and its relationship to fetal neurodevelopment; (3) life course epidemiologic research with ethnic/racial minority populations; (4) phenomenology and assessment of inhibitory control in toddlers; and (5) responsible conduct in scientific research. This project will investigate the influence of high maternal prenatal body mass index (BMI) on frontostrialal connectivity (i.e., circuits implicated in inhibitory control disorders) in offspring infants (Aim #1) and on behavioral assessments of inhibitory control at age 2 (Aim # 2). It is hypothesized that inflammation is a key mediator (i.e. mechanism) by which maternal prenatal BMI leads to disruptions in frontostriatal connectivity in infants and impaired inhibitory control in toddlers. The project will collect prenatal assessments of maternal BMI and inflammation, resting state fMRI data from infants at 2-4 weeks of age, and behavioral and parent report measures of inhibitory control abilities at age 2. Currently, the proposed study participants are enrolled in the NIH Environmental influences on Child Health Outcomes (ECHO) study, which will collect MRI data on 500 infants. Building on this structure, we propose to select a subsample (n=76) of average (BMI=18.5– 24.9 kg m−2; n=38) and obese (BMI⩾30 kg m−2; n=38) pregnant women and offspring to include in this project. Data yielded from the proposed study will lead to a future R01 application examining offspring's inhibitory control circuits longitudinally. Together, the research and training experiences and expertise developed through this K08 award will support the applicant's transition to research independence and ensure the applicant becomes a leading authority in the prenatal origins of inhibitory control deficits.

项目概要 该 K08 应用旨在检查抑制控制困难的潜在胎儿起源：子宫内暴露 这项研究通过检查产前母亲肥胖的抑制控制缺陷填补了一个重要空白。 美国波多黎各人的代际样本。 肥胖和冲动相关疾病（例如注意力缺陷/多动症）有所增加 （注意力缺陷多动症），但仍然没有得到充分研究。这个为期五年的 K08 应用程序提出了一个研究和计划。 培训将支持申请人成为一名独立调查员，重点是 通过跨学科方法（生命历程）研究抑制控制缺陷的早期起源 流行病学、婴儿神经影像学和生物统计学）培训计划以候选人之前的培训为基础。 和经验，并利用优秀的导师团队和研究环境来培养 发展考生在 (1) 收集、分析和解释婴儿静息状态方面的专业知识 功能磁共振成像（fMRI）数据；（2）围产期体重与炎症及其关系； 胎儿神经发育；（3）少数族裔/种族人群的生命历程流行病学研究； 幼儿抑制控制的现象学和评估；以及 (5) 负责任的科学行为； 该项目将调查高产妇产前体重指数（BMI）对孕妇的影响。 子代婴儿的额叶连通性（即与抑制性控制障碍有关的回路）（目标#1）和 2 岁时抑制控制的行为评估（目标#2）。人们再次认识到炎症是关键。 母亲产前 BMI 导致额纹状体连接中断的中介因素（即机制） 该项目将收集母亲的产前评估。 BMI 和炎症、2-4 周龄婴儿的静息态 fMRI 数据以及行为和父母 报告 2 岁时抑制控制能力的测量结果。目前，拟议的研究参与者已入组 在 NIH 环境对儿童健康结果的影响 (ECHO) 研究中，该研究将收集以下方面的 MRI 数据： 在此结构的基础上，我们建议选择 500 名婴儿的平均值 (BMI=18.5–) 的子样本 (n=76)。 24.9 kg m−2；n=38）和肥胖（BMI⩾30 kg m−2；n=38）孕妇和后代纳入该项目。 拟议研究产生的数据将导致未来的 R01 应用检查后代的抑制 纵向控制电路共同发展了研究和培训经验以及专业知识。 通过此 K08 奖项将支持申请人向研究独立性过渡，并确保 申请人成为抑制控制缺陷产前起源的主要权威。