Novel MRI Methods for Osteochondritis Dissecans (OCD) / Osteochondrosis (OC)

剥脱性骨软骨炎 (OCD)/骨软骨病 (OC) 的新 MRI 方法

• 批准号: 10226272
• 负责人: Cathy S. Carlson
• 金额: $ 44.64万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10226272
• 关键词: 16 year old; 6 year old; 7 year old; Acceleration; Address; Adolescent; Affect; Age; Animal Model; Architecture; Area; Arthritis; Autopsy; Blood Vessels; Cadaver; Cartilage; Cartilage Matrix; Characteristics; Child; Childhood; Clinical; Collaborations; Contralateral; Data; Degenerative polyarthritis; Development; Diagnosis; Disease; Distal; Etiology; Evaluation; Evidence based treatment; Failure; Family suidae; Feasibility Studies; Femur; Functional disorder; Future; Goals; Goat; Growth; Histologic; Human; Image; Imaging Techniques; Interdisciplinary Study; Knee; Knee joint; Knowledge; Lead; Lesion; Lesion by Stage; Magnetic Resonance; Magnetic Resonance Imaging; Methods; Minnesota; Monitor; Morphology; Necrosis; Non-Invasive Lesion; Normal tissue morphology; Operative Surgical Procedures; Orthopedics; Osteochondritis Dissecans; Osteochondrosis; Pathogenesis; Patients; Pattern; Positioning Attribute; Predisposition; Prevention; Process; Protocols documentation; Research; Research Personnel; Resolution; Resources; Role; Sampling; Secondary to; Severities; Site; Specimen; Structure; Surgical Flaps; Techniques; Testing; Time; Tissues; Universities; Validation; Vascular blood supply; Work; aged; base; bone; clinical imaging; developmental disease; disease diagnosis; ex vivo imaging; human disease; human model; imaging modality; improved; in vivo; in vivo imaging; non-invasive imaging; novel; novel diagnostics; novel therapeutic intervention; premature; prevent; repaired; treatment strategy

Project Summary/Abstract Osteochondritis Dissecans (OCD)/Osteochondrosis (OC) is an important orthopaedic disease in children; however, the etiology and pathogenesis remain unclear. OCD/OC is highly prevalent (nearly 100% affected) in growing pigs causing lameness. Previous work by our group has demonstrated that the pathogenesis of OCD/OC in pigs involves failure of cartilage canal blood supply, with resulting necrosis of epiphyseal (growth) cartilage. We hypothesize that the pathogenesis of OC/OCD in children is similar; however, the relationship between failed cartilage canal blood supply and osteochondritis dissecans (OCD) in people has not been studied due to 1) lack of noninvasive imaging techniques to visualize these structures in vivo and 2) limited access to appropriate post mortem tissues. We have developed a unique collaboration among magnetic resonance imaging (MRI) experts and veterinary and human orthopaedic researchers that will make use of the exceptional resources at the Center for Magnetic Resonance Research at the University of Minnesota to fill in the above mentioned gaps in knowledge. Our group recently developed and validated MRI methods to identify cartilage canal blood vessels and ischemic necrosis of the epiphyseal cartilage in young pigs. We wish to extend these studies to children and adolescents to investigate the maturation process of the articular- epiphyseal cartilage of the distal femur noninvasively in humans and compare it to that occurring in swine. This will be accomplished by the completion of four specific aims. Aims 1 and 2 focus on the development/ implementation/validation of novel MRI techniques, ex vivo, to image the vascular supply and cartilage matrix characteristics/morphology in cadaveric specimens from normal children and from young pigs in which subclinical lesions of osteochondrosis will be present (allowing evaluation of normal tissues as well as of areas of cartilage necrosis). Aims 3 and 4 focus on the development and testing of a rapid pediatric imaging protocol for in vivo studies in normal children and children first diagnosed with OCD. This research will have multiple benefits by 1) validating swine as a highly appropriate animal model of this important human disease, 2) providing a method to diagnose the disease at an early point in its development at which time treatments are likely to be effective, and 3) greatly improving our understanding of the pathophysiology of the disease.

项目概要/摘要 剥脱性骨软骨炎（OCD）/骨软骨病（OC）是儿童重要的骨科疾病； 然而，其病因和发病机制仍不清楚。 OCD/OC 在以下国家非常普遍（几乎 100% 受影响） 生长猪导致跛行。我们课题组之前的工作已经证明，该病的发病机制 猪的 OCD/OC 涉及软骨管血液供应失败，导致骨骺坏死（生长） 软骨。我们假设儿童 OC/OCD 的发病机制是相似的；然而，这种关系 人类软骨管血液供应失败与剥脱性骨软骨炎 (OCD) 之间的关系尚未得到证实 研究的原因是 1) 缺乏在体内可视化这些结构的非侵入性成像技术，2) 有限 获得适当的死后组织。我们在磁性材料之间建立了独特的合作关系 磁共振成像（MRI）专家以及兽医和人类骨科研究人员将利用 明尼苏达大学磁共振研究中心的特殊资源可以填补 上面提到的知识差距。我们的小组最近开发并验证了 MRI 方法来识别 幼猪软骨管血管和骨骺软骨缺血性坏死。我们希望 将这些研究扩展到儿童和青少年，以调查关节的成熟过程 对人类股骨远端骨骺软骨进行无创性研究，并将其与猪的骨骺软骨进行比较。这 将通过完成四个具体目标来实现。目标 1 和 2 侧重于发展/ 实施/验证新型 MRI 技术，离体，对血管供应和软骨基质进行成像 正常儿童和幼猪尸体标本的特征/形态学，其中 将出现骨软骨病的亚临床病变（允许评估正常组织以及区域 软骨坏死）。目标 3 和 4 侧重于快速儿科成像方案的开发和测试 用于正常儿童和首次诊断为强迫症儿童的体内研究。这项研究将有多个 益处包括：1) 验证猪作为这种重要人类疾病的高度合适的动物模型，2) 提供一种在疾病发展的早期阶段诊断疾病​​的方法，此时可以进行治疗 可能有效，并且3）极大地提高了我们对该疾病病理生理学的理解。

项目成果

Descriptive Epidemiology From the Research in Osteochondritis Dissecans of the Knee (ROCK) Prospective Cohort.

膝关节剥脱性骨软骨炎 (ROCK) 前瞻性队列研究的描述性流行病学。

• 发表时间: 2022-01
• 作者: Nissen, Carl W;Albright, Jay C;Anderson, Christian N;Busch, Michael T;Carlson, Cathy;Carsen, Sasha;Chambers, Henry G;Edmonds, Eric W;Ellermann, Jutta M;Ellis Jr, Henry B;Erickson, John B;Fabricant, Peter D;Ganley, Theodore J;Green, Daniel W
• 通讯作者: Green, Daniel W

Measuring Knee Bone Marrow Perfusion Using Arterial Spin Labeling at 3 T.

使用动脉旋转标记在 3°T 测量膝关节骨髓灌注。

• 发表时间: 2020
• 影响因子: 4.6
• 作者: Li, Xiufeng;Johnson, Casey P;Ellermann, Jutta
• 通讯作者: Ellermann, Jutta

Using a simplified version of a common surgical grading scale for acetabular labral tears improves the utility of preoperative hip MRI for femoroacetabular impingement.

使用简化版本的髋臼盂唇撕裂常见手术分级量表可以提高术前髋关节 MRI 对股骨髋臼撞击的实用性。

• 发表时间: 2020-12
• 影响因子: 2.1
• 作者: Morgan, Patrick;Crawford, Amanda;Marette, Shelly;Takahashi, Takashi;Luchsinger, Joseph;Kirkham, James;Wu, Baolin;Ellermann, Jutta M
• 通讯作者: Ellermann, Jutta M