Core A: Administrative Core

核心A：行政核心

• 批准号: 10223992
• 负责人: Warner C. Greene
• 金额: $ 10.11万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-08 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223992
• 关键词: Aftercare; Area; Back; Bioinformatics; Biological Markers; Biostatistics Core; Biotechnology; Blood Cells; Clinical; Clinical Trials; Collaborations; Communication; Communities; Contracts; Data; Decision Making; Doctor of Philosophy; Ensure; Exposure to; Funding; Future; Goals; Gold; Grant; HIV; Immunologist; Immunology; Impairment; Institutes; Institution; Interruption; Intervention; Investigation; Lead; Logistics; Mission; Monitor; Pathway interactions; Patients; Performance; Plasma; Privatization; Process; Productivity; Resources; Robin bird; Sampling; Schedule; Services; Site; Specimen; Strategic Planning; Structure; Testing; Therapeutic; Therapeutic Intervention; Time; United States National Institutes of Health; Videoconferencing; Work; base; cost; data exchange; meetings; member; predictive marker; programs; sound; success; viral rebound; virology; volunteer; web site

Project Summary/Abstract The overall success of the proposed BioMark project team depends on an efficient and highly organized Administrative Core that effectively coordinates the team's efforts. The central mission of the proposed BioMark project is to identify a robust set of biomarkers predicting time to rebound following treatment interruption in HIV infected patients. This core will sek to remove or reduce the obstacles that might impair the team from achieving its experimental goals. Keys to success are the orchestration of lively and informative team meetings and the nucleation of the team in a manner that promotes synergistic rather than additive scientific collaboration. The Administrative Core is organized around three specific aims: Specific Aim 1: To provide a sound, effective administrative structure for the BioMark team that maximizes scientific productivity, promotes free and open communication among members, allows for strategic planning on a regular basis, ensures the implementation of sound fiscal practices to maximize resources and productivity, and promotes the appropriate sharing, collation, and analyses of the scientific data generated. Specific Aim 2: To conduct an annual scientific review of progress of the BioMark team by a Scientific Advisory Board comprised of three members (beginning in year 3). Specific Aim 3: To regularly evaluate internally the performance of all scientific projects and cores and, based on need or performance, to reallocate resources in a manner that best serves the overall goals of the BioMark team. Dr. Warner Greene will serve as Director of this Core. This core will be based at the Gladstone Institute of Virology and Immunology (GIVI), an institution widely recognized for the excellence of its administrative services. Additional administrative staff participating in BioMark will include Julia Roudabush (Gladstone Grants and Contracts) and Robin Givens (Senior Executive Assistant, Office of the Director, GIVI). The Administrative Core will schedule biweekly videoconferences of BioMark's Executive Committee (Greene chair, Pillai, Roan, Siliciano) alternating with videoconferencing meetings of the entire BioMark team for review of results and discussion of future experimentation. The Executive Committee will function as the principal decision-making body within the program. The Administrative Core will also organize an annual strategic planning process and be responsible for launching BioMark's website to include public and private portals, the latter facilitating data exchange among team members. In Year 3, a Scientific Advisory Board will be assembled with plans to invite a bioinformatician, HIV immunologist, and an HIV clinical trialist to join as members and to conduct an annual review of the entire program. The Administrative Core will also take the lead on ensuring smooth specimen acquisition for the four different collaborating ATI trial sites and ensuring a smooth interface between the three projects and the Bioinformatics and Biostatistics Core.

项目概要/摘要 所提议的 BioMark 项目团队的整体成功取决于高效且高度组织的团队 有效协调团队工作的行政核心。拟议的中心任务 BioMark 项目旨在确定一组强大的生物标志物，预测治疗后的反弹时间 HIV感染者的中断。该核心将寻求消除或减少可能损害的障碍 团队无法实现其实验目标。成功的关键是精心编排生动且信息丰富的内容 团队会议和团队核心化的方式是促进协同而非相加 科学合作。行政核心围绕三个具体目标进行组织： 具体目标 1： 为 BioMark 团队提供健全、有效的管理结构，最大限度地提高科学生产力， 促进成员之间自由和开放的沟通，允许定期进行战略规划， 确保实施健全的财政做法，以最大限度地提高资源和生产力，并促进 对所生成的科学数据进行适当的共享、整理和分析。具体目标 2：进行 由三名成员组成的科学顾问委员会对 BioMark 团队的进展进行年度科学审查 成员（从第 3 年开始）。具体目标 3：定期内部评估所有员工的绩效 科学项目和核心，并根据需要或绩效，以最适合的方式重新分配资源 服务于 BioMark 团队的总体目标。 Warner Greene 博士将担任该核心的主任。这个核心 将设在格拉德斯通病毒学和免疫学研究所 (GIVI)，该机构因 其卓越的行政服务。参与 BioMark 的其他管理人员将包括 Julia Roudabush（格拉德斯通赠款和合同）和 Robin Gives（高级行政助理，办公室） GIVI 主任）。行政核心将安排 BioMark 执行官每两周召开一次视频会议 委员会（Greene 主席、Pillai、Roan、Siliciano）与整个委员会轮流召开视频会议 BioMark 团队负责审查结果并讨论未来的实验。执行委员会将 作为该计划的主要决策机构。行政核心还将组织 年度战略规划流程，并负责启动 BioMark 网站，以包括公众和 私人门户网站，后者促进团队成员之间的数据交换。第三年，科学咨询 董事会将召开会议，计划邀请一名生物信息学家、艾滋病毒免疫学家和一名艾滋病毒临床试验员 作为成员加入并对整个计划进行年度审查。行政核心还将采取 在确保四个不同的 ATI 合作试验中心顺利采集样本方面处于领先地位， 确保三个项目与生物信息学和生物统计学核心之间的顺利衔接。