Administrative Core

行政核心

• 批准号: 10232834
• 负责人: Edward M. Schwarz
• 金额: $ 27.7万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10232834
• 关键词: Academic Medical Centers; Award; Basic Science; Biochemistry; Biocompatible Materials; Biology; Biomechanics; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Communication; Communities; Country; Custom; Data Science; Department chair; Direct Costs; Elements; Endowment; Ensure; Exercise; Faculty; Feedback; Fostering; Funding; Goals; Grant; Growth; Histology; Human Subject Research; Institutes; International; Investments; Leadership; Letters; Malignant Neoplasms; Mentors; Mission; Monitor; Multimodal Imaging; Muscle; Musculoskeletal; Names; Orthopedics; Productivity; Publications; RNA; Reproducibility; Research; Research Personnel; Resource Sharing; Resources; Role; Running; Series; Services; Strategic Planning; Structure; Tissue imaging; Translating; Translational Research; Translations; Underrepresented Minority; United States National Institutes of Health; Universities; Visit; Work; academic program; base; big-data science; bone; clinical application; clinical translation; collaborative environment; cost effective; design; high standard; innovation; laboratory facility; meetings; mid-career faculty; molecular imaging; multimodality; nutrition; outreach; population health; professor; programs; ranpirnase; recruit; response; success; surgery outcome; symposium; tenure track

Abstract The Administrative Core will run the Enrichment Program, and will coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, Biomaterials and Multimodal Tissue Imaging (B2MTI) Cores, in order to ensure progress of the Rochester Resource- based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) in an efficient manner. The Core Users Committees, the URMC Shared Resource Laboratories & Facilities, and meeting structure of the Administrative Core are key elements that organize the communication and collaboration among the ROCSTARR investigators, as well as with other faculty in the Center for Musculoskeletal Research (CMSR) and collaborating Departments and Centers within the University. The activities of the Co-Directors, Mentors, Advisors, and staff in the Administrative Core will be tightly monitored by the Core Users Committee, which is made up of junior to mid-career faculty and trainees, and was established in our 2019 Center for Musculoskeletal Research (CMSR) 5-year Strategic Plan to provide direct feedback. These activities, which will be formally reviewed weekly by the Co-Directors, are embodied by the following Specific Aims. 1) To maintain state-of-the-art resource-based Cores for basic science, translational and clinical bone, muscle & orthopaedic research; and utilize these resources in a cost-effective manner to accelerate the pace of discovery and clinical translation. 2) To continue to foster our highly collaborative environment that translates basic research into clinical trials, and to expand our outreach activities with a new focus on underrepresented minorities, to promote the use of the resources offered by the P30 Core to new external collaborations that will grow our musculoskeletal research base at URMC, nationally and internationally. 3) To grow our Pilot Grant Program from $100,000 to $130,000 per year with a new parallel Discovery Fund, with which the Mentoring Core will expeditiously allocate small grants up to $5,000. We will also enhance our Enrichment Programs beyond these Pilot Grants, the William F. Neuman Visiting Professor series, and Annual Musculoskeletal Research Symposium, by expanding the community and promoting innovative research in bone, muscle and orthopaedic research. 4) To maintain our Clinical-Translational Sub- Core that administers human subject research services leveraging and customizing resources from the Clinical-Translational Science Institute, to enhance the translation of musculoskeletal basic science to clinical application, and grow collaborative networks with a new emphasis on Big Data science, surgical outcomes and population health research. And, 5) To expand our highly successful Mentoring Program, which facilitates the advancement of our New/Early Stage Investigators to NIH R01 funded PIs and national leadership status, and implements the highest standards of scientific rigor in response to NIH’s plan to enhance reproducibility. Execution of these aims will accelerate and enhance the productivity and establishment of the musculoskeletal research work force at URMC and beyond.

抽象的 行政核心将运行丰富计划，并将协调和整合 组织学、生物化学和分子成像 (HBMI) 以及生物力学、生物材料和 多模态组织成像 (B2MTI) 核心，以确保罗切斯特资源项目的进展 以高效的方式建立骨、肌肉和骨科研究中心 (ROCSTARR)。 核心用户委员会、URMC 共享资源实验室和设施以及会议 行政核心的结构是组织沟通和交流的关键要素 ROCSTARR 研究人员以及中心其他教员之间的合作 肌肉骨骼研究 (CMSR) 以及大学内的合作部门和中心。 行政核心的联合主任、导师、顾问和工作人员的活动将紧密结合 由核心用户委员会监督，该委员会由初级到中期职业教师和实习生组成， 并在我们的 2019 年肌肉骨骼研究中心 (CMSR) 五年战略计划中成立，以 这些活动将由联合董事每周进行正式审查， 具体体现为以下具体目标 1) 维护最先进的基于资源的核心。 基础科学、转化和临床骨骼、肌肉和骨科研究并利用这些； 以具有成本效益的方式提供资源，加快发现和临床转化的步伐 2) 继续培育我们高度协作的环境，将基础研究转化为临床试验， 并扩大我们的外展活动，将新的重点放在代表性不足的少数群体上，以促进 利用 P30 Core 提供的资源进行新的外部合作，这将发展我们的 URMC 的国内和国际肌肉骨骼研究基地 3) 增加我们的试点补助金。 每年提供 100,000 至 130,000 美元的计划，并设立一个新的并行探索基金， Mentoring Core 将迅速分配高达 5,000 美元的小额赠款，我们还将加强我们的援助。 除了这些试点补助金、威廉·F·纽曼客座教授系列之外的丰富项目，以及 年度肌肉骨骼研究研讨会，通过扩大社区和促进创新 骨骼、肌肉和骨科研究 4) 维持我们的临床转化子项目。 管理人类课题研究服务的核心，利用和定制来自 临床转化科学研究所，加强肌肉骨骼基础科学向临床转化的转化 临床应用，并发展协作网络，新重点是大数据科学、外科 成果和人口健康研究，以及，5) 扩大我们非常成功的指导。 计划，促进我们的新/早期研究人员晋升为 NIH R01 资助的项目 PI 和国家领导地位，并实施科学严谨的最高标准来应对 NIH 提高可重复性的计划将加速和增强这些目标的执行。 URMC 及其他地区的生产力和肌肉骨骼研究队伍的建立。