Rochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)

罗切斯特骨骼、肌肉和骨科研究资源中心 (ROCSTARR)（整体申请）

• 批准号: 10232833
• 负责人: Edward M. Schwarz
• 金额: $ 77万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10232833
• 关键词: Academic Medical Centers; Address; Animal Model; Award; Basic Science; Biochemistry; Biocompatible Materials; Biology; Biomechanics; Biometry; Budgets; Clinical; Clinical Research; Clinical Trials; Collaborations; Communication; Communities; Country; Department chair; Direct Costs; Effectiveness; Elements; Endowment; Ensure; Environment; Exercise; Faculty; Female; Fostering; Funding; Goals; Grant; Histology; Human Subject Research; Infrastructure; International; Investments; Leadership; Letters; Medicine; Mentors; Mission; Modeling; Muscle; Musculoskeletal; Orthopedics; Outcomes Research; Paper; Physicians; Publications; Reproducibility; Research; Research Assistant; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resource Sharing; Resources; Role; Running; Scientist; Seeds; Series; Services; Structure; Talents; Tissue imaging; Translational Research; Translations; United States National Institutes of Health; Universities; Visit; Work; academic program; base; big-data science; bone; clinical translation; collaborative environment; computer program; cost effective; high standard; human subject; improved; laboratory facility; male; meetings; member; molecular imaging; multimodality; next generation; novel; outreach; population health; professor; programs; ranpirnase; research facility; response; success; surgery outcome; symposium; tenure track; tool

This is a proposal to sustain the University of Rochester Resource-based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) Program. ROCSTARR is comprised of an Administrative Core that will run the Enrichment Program, and will coordinate and integrate the Histology, Biochemistry and Molecular Imaging (HBMI) and the Biomechanics, Biomaterials and Multimodal Tissue Imaging (B2MTI) Cores, in order to ensure progress of the overall ROCSTARR in an efficient manner. The Core Users Committees, the URMC Shared Resource Laboratories & Facilities, and the meeting structure of the Administrative Core are key elements that organize communication and collaboration among the ROCSTARR investigators, as well as with other faculty in the Center for Musculoskeletal Research (CMSR) and collaborating Departments and Centers within the University. The Specific Aims of the ROCSTARR are: 1) To maintain state-of-the-art resource- based Cores for basic science, translational and clinical musculoskeletal research; and utilize these resources in a cost-effective manner to accelerate the pace of discovery and clinical translation. 2) To continue to foster our highly collaborative environment that serves as a model for translation of basic research to clinical trials, and expands our outreach activities that promote the use of the resources offered by the Core to new external collaborations with the aim of growing our musculoskeletal research base at URMC, nationally and internationally. 3) To: i) maintain our exceptional 42-fold return on investment from Pilot Grants awarded to New/Early Stage Investigators (N/ESI), ii) commence utilization of a new Discovery Fund created with small endowments for research in the prior funding period, and grow it via targeted philanthropy, and iii) sustain our renowned academic Enrichment Programs including the William F. Neuman Visiting Professor series and the Annual Musculoskeletal Research Symposium. 4) To maintain our Sub-Cores that administer: i) human subject research services in concert with the Clinical-Translational Research Institute, ii) biostatistics, computer programing and outcome research resources to grow collaborative networks in Big Data science, surgical outcomes and population health research, and iii) provide new resources for muscle and exercise biology research in animal models and human subjects. And, 5) to expand our highly successful Mentoring Program, which facilitates the advancement of our N/ESIs to NIH R01 funded PIs with national leadership status, and implements the highest standards of scientific rigor in response to NIH’s plan to enhance reproducibility. Thus, building on our remarkable successes during the prior funding period, this P30 Core Center proposes to continue its mission “To advance our faculty members to independence, establishing them as national leaders and the most desirable faculty in their field by the top academic programs in the country, upon which the ultimate success of this Core Program will be judged.”

这是一项旨在维持罗彻斯特大学骨骼、肌肉和骨骼资源中心的提案 骨科研究 (ROCSTARR) 计划由一个行政核心组成，该核心将 运行浓缩计划，并将协调和整合组织学、生物化学和分子学 成像 (HBMI) 和生物力学、生物材料和多模态组织成像 (B2MTI) 核心，以便 确保核心用户委员会、URMC 的整体 ROCSTARR 取得有效进展。 共享资源实验室和设施以及行政核心的会议结构是关键 组织 ROCSTARR 调查人员之间以及与 肌肉骨骼研究中心 (CMSR) 以及合作部门和中心的其他教员 ROCSTARR 的具体目标是： 1) 保持最先进的资源- 基础科学、转化和临床肌肉骨骼研究的核心并利用这些资源； 以具有成本效益的方式加快发现和临床转化的步伐 2) 继续培育。 我们高度协作的环境是基础研究转化为临床试验的典范， 并扩大我们的外展活动，促进利用核心提供的资源到新的外部 合作的目的是扩大我们在 URMC 的肌肉骨骼研究基地，在全国范围内 3) 为了：i) 维持我们从试点补助金中获得的 42 倍的卓越投资回报 新/早期研究人员 (N/ESI)，ii) 开始利用由小额资金创建的新发现基金 上一个资助期间的研究捐赠，并通过有针对性的慈善事业来增加它，以及 iii) 维持我们的 著名的学术强化项目，包括威廉·F·诺伊曼客座教授系列和 年度肌肉骨骼研究研讨会 4) 维护我们的子核心，管理：i) 人类。 与临床转化研究所合作提供主题研究服务，ii) 生物统计学、计算机 规划和成果研究资源，以发展大数据科学、外科领域的协作网络 结果和人口健康研究，以及 iii) 为肌肉和运动生物学提供新资源 动物模型和人类受试者的研究，5) 扩大我们非常成功的指导计划， 这有助于我们的 N/ESI 晋升为 NIH R01 资助的具有国家领导地位的 PI，以及 实施最高标准的科学研究，以响应 NIH 提高可重复性的计划。 基于我们在上一个资助期间取得的显着成功，这个 P30 核心中心建议： 继续其使命“促进我们的教职人员走向独立，将他们培养成国家领导人 以及该国顶尖学术项目在其领域中最理想的教师，在此基础上 该核心计划的最终成功将由我们来评判。”