CARE4Kids: Administrative Core

CARE4Kids：行政核心

• 批准号: 10203598
• 负责人: CHRISTOPHER C GIZA
• 金额: $ 21.78万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-08 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10203598
• 关键词: Adolescent; Affect; Age; Biological; Biological Markers; Blood; Blood Tests; Brain; Brain Concussion; Brain scan; Cardiovascular system; Caring; Categories; Childhood; Clinical; Clinical Data; Collaborations; Common Data Element; Data; Data Collection; Data Store; Development; Education; Ensure; Equilibrium; Functional disorder; Funding; Future; Goals; Guidelines; Image; Individual; Information Dissemination; Injury; Lead; Leadership; Link; Measurable; Measures; Medical; Methods; Molecular; Monitor; National Institute of Neurological Disorders and Stroke; Nature; Nervous System Physiology; Neurobiology; Neurocognitive Deficit; Outcome; Patients; Pattern; Persistent pain; Persons; Phase; Physiological; Post-Concussion Syndrome; Prevention; Procedures; Process; Public Health; Publications; Publishing; Quality Control; Recovery; Research; Research Personnel; Resources; Risk; Role; Saliva; Scientific Inquiry; Site; Sports; Standardization; Structure; Symptoms; Testing; Time; TimeLine; Training; Training and Infrastructure; Traumatic Brain Injury; Validation; Vehicle crash; Work; Youth; biological adaptation to stress; brain electrical activity; clinical biomarkers; cognitive testing; comorbidity; data collection site; data curation; data dissemination; data sharing; data standards; disability; endophenotype; experience; falls; improved; injured; meetings; persistent symptom; prognostic; programs; sex; treatment trial

PROJECT SUMMARY/ABSTRACT - Administrative Core Concussion is a form of traumatic brain injury that affects millions annually, particularly adolescents. While many recover, a large number of injured youth go on to develop persistent post-concussive symptoms (PPCS), and experience ongoing pain, dysfunction and disability. Due to the variability of concussion and the subjective nature of post-concussive symptoms, our ability to predict and classify those who develop PPCS is currently very limited. Research suggests that specific patterns of PPCS may be linked to different underlying pathophysiology. The primary goal of the CARE4Kids Center Without Walls (CWOW) is to identify measurable biological markers (blood tests, brain scans, electrical activity, etc.) that will help objectively predict and define different categories of PPCS. The primary goal of the CARE4Kids CWOW Administrative Core is to provide the necessary leadership, organization, training and infrastructure to permit efficient coordination of 6 clinical data collection sites with designated centers able to provide quality control and maintain and store data. The Administrative Core will provide training and oversight for all data collection of clinical and biological measures. Biological measures may include cognitive tests, brain electrical activity, scans of brain structure, molecules in blood or saliva, cardiovascular testing and stress responses. The Administrative Core also will establish guidelines for the CARE4Kids CWOW to monitor funding, scientific inquiry, data curation and sharing, and dissemination of results. Other important roles include standardizing definitions, developing consistent methods and coordinating an annual meeting to ensure the consortium has an open forum to meet, share information and troubleshoot unanticipated challenges. The results of this work will lead to improved, but objective, medical tests that help predict which patients with concussions are at greatest risk for PPCS. By defining objective categories of those at risk for PPCS, it will be possible to better provide medical care, and will also lead to future trials for new treatments.

项目摘要/摘要 - 行政核心 脑震荡是一种创伤性脑损伤，每年影响数百万人，尤其是青少年。尽管 许多人康复了，大量受伤的青少年继续出现持续性脑震荡后症状（PPCS）， 并经历持续的疼痛、功能障碍和残疾。由于脑震荡的可变性和主观 由于脑震荡后症状的性质，我们目前对 PPCS 患者进行预测和分类的能力还很有限 非常有限。研究表明 PPCS 的特定模式可能与不同的潜在因素有关 病理生理学。 CARE4Kids 无墙中心 (CWOW) 的主要目标是确定可衡量的 有助于客观预测和定义的生物标记（血液测试、脑部扫描、电活动等） 不同类别的 PPCS。 CARE4Kids CWOW 管理核心的主要目标是 提供必要的领导、组织、培训和基础设施，以实现高效 协调 6 个临床数据收集点与能够提供质量控制的指定中心 并维护和存储数据。管理核心将为所有数据收集提供培训和监督 临床和生物学测量。生物测量可能包括认知测试、脑电活动、 扫描大脑结构、血液或唾液中的分子、心血管测试和压力反应。这 行政核心还将为 CARE4Kids CWOW 制定指导方针，以监控资金、科学 调查、数据整理和共享以及结果传播。其他重要作用包括标准化 定义、制定一致的方法并协调年度会议，以确保联盟 一个开放的论坛，用于满足、共享信息和解决意外挑战。这项工作的结果 将导致改进但客观的医学测试，帮助预测哪些脑震荡患者处于危险状态 PPCS 的最大风险。通过定义 PPCS 风险人群的目标类别，将有可能更好地 提供医疗护理，还将导致未来新疗法的试验。