Predoctoral Training at the Chemistry-Biology Interface

化学-生物学界面的博士前培训

• 批准号: 10202660
• 负责人: Ronen Marmorstein
• 金额: $ 29.26万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10202660
• 关键词: Biology; Chemistry; Training; pre-doctoral

The goal of the CBI Training Program is to provide students with the intellectual and technical skills that are necessary to solve important and complex biological problems that can be most effectively addressed by studies at the chemistry-biology interface. We are focusing on the mechanistic chemistry of biomolecules that have implications for impacting human health and treatment of disease. This is a theme that is of interest to a significant population of students on campus and serves as an excellent system for the application of tools at the chemistry-biology interface to solve important biological problems. The program creates a group of chemists and biologists who can speak the same language and thereby function effectively in multidisciplinary teams. The Program involves 34 participating faculty from two separate Schools within the University of Pennsylvania, The Perelman School of Medicine (SOM) and The School of Arts and Sciences (SAS). Participating students come primarily from two graduate groups that span institution and school boundaries, the Graduate Group in Chemistry (CHEM, in SAS) and the Graduate Group in Biochemistry and Molecular Biophysics (BMB, in SOM). To ensure that students carry out research within the scope of the training program, students are selected for the program after they have chosen a thesis laboratory and project and generally in their second year. To ensure chemistry-biology interface training and cross-fertilization between the chemistry and biology students that participate in the program, students participate in the following activities: (1) research at the chemistry-biology interface, (2) didactic course-work dealing with the chemistry and biology of proteins, nucleic acids and small biomolecules, including a literature-based component, (3) an annual student-run Chemical Biophysics mini-symposia series, (4) twice monthly student luncheons, (5) an annual Chemistry-Biology Interface retreat, (6) an annual mid-Atlantic Frontiers at the Chemistry-Biology Interface Symposium, and (7) a structured career development plan. The program also has effective mechanisms in place for the recruitment and retention of underrepresented minorities as well as the disadvantaged and disabled, and for student instruction in the responsible conduct of research. We request funds for a steady state predoctoral training group of ~ 40 students, including 8 who are funded during years 2 and 3. Oversite of the Training Program is by the PI, Ronen Marmorstein and Co-PI, E. James Petersson, with input from CHEM (SAS) and BMB (SOM) External Advisory Committees and Internal CBI Training Committee, comprised of roughly equal faculty representation from the two participating schools and trainee representatives, which meets every 6 months. The CBI Training Committee votes on the selection of students for funded training slot positions, ensuring equitable distribution of students, encouraging applications from underrepresented minorities, the disadvantaged and disabled and administering other functions of the program.

CBI 培训计划的目标是为学生提供所需的智力和技术技能 解决重要而复杂的生物学问题所必需的，而这些问题可以通过以下方法最有效地解决： 化学-生物学界面的研究。我们专注于生物分子的机械化学 对影响人类健康和疾病治疗具有影响。这是一个大家感兴趣的主题 校园内有大量学生，是应用工具的优秀系统 化学-生物学接口来解决重要的生物学问题。该程序创建了一组 化学家和生物学家可以说同一种语言，从而在多学科中有效地发挥作用 团队。该计划涉及来自大学内两个不同学院的 34 名参与教师 宾夕法尼亚州、佩雷尔曼医学院 (SOM) 和艺术与科学学院 (SAS)。 参与的学生主要来自两个跨越机构和学校边界的研究生群体， 化学研究生组（CHEM，SAS）和生物化学和分子研究生组 生物物理学（BMB，SOM）。确保学生在培训范围内开展研究 计划，学生在选择论文实验室和项目后被选入该计划，并且 一般是在第二年。确保化学-生物学接口培训和交叉受精 参加该计划的化学和生物学生，学生参加以下活动 活动：(1) 化学-生物学界面研究，(2) 涉及化学的教学课程作业 蛋白质、核酸和小生物分子的生物学，包括基于文献的部分，(3) 年度学生举办的化学生物物理学小型研讨会系列，(4) 每月两次的学生午餐会，(5) 年度化学-生物学界面静修会，(6) 年度化学-生物学中大西洋前沿 接口研讨会，以及 (7) 结构化的职业发展计划。该方案还具有有效 招聘和保留代表性不足的少数群体的机制以及 弱势和残疾人，并指导学生负责任地进行研究。我们要求 资助约 40 名学生的稳定状态博士前培训小组，其中 8 名学生在第 2 年获得资助 3. 培训计划的现场指导由 PI Ronen Marmorstein 和联合 PI E. James Petersson 负责，并由 CHEM (SAS) 和 BMB (SOM) 外部咨询委员会和内部 CBI 培训委员会的意见， 由来自两所参与学校和实习生的教师代表大致相等 代表，每 6 个月举行一次会议。 CBI培训委员会投票选出学生 对于受资助的培训职位职位，确保学生的公平分配，鼓励来自 代表性不足的少数群体、弱势群体和残疾人以及管理该机构的其他职能 程序。