VISION RESEARCH

愿景研究

• 批准号: 2158002
• 负责人: COLIN J BARNSTABLE
• 金额: $ 25.33万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-08-01 至 1997-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2158002
• 关键词: biomedical equipment resource; biomedical resource; electron microscopy; eye disorder; eye pharmacology; high performance liquid chromatography; monoclonal antibody; nucleic acid sequence; photography; polymerase chain reaction; tissue /cell culture; vision

The overall objective of this core grant is enhance vision research at Yale University. By providing five key support modules, this grant will enhance the ongoing research projects of individual investigators by providing facilities and expertise that cannot be supported by individual research grants. The modules will also serve to promote and facilitate collaborative interactions between investigators and will encourage pilot projects from which specific research proposals can be developed. Finally, the modules of this core grant will serve as an invaluable resource for trainees of the Yale Visual Sciences Training Program which sponsors both pre- and postdoctoral fellows. The specific modules proposed in this application include a machine shop and a photography module, both of which serve obvious functions. A tissue culture/hybridoma module will provide complete facilities for the initiation and maintenance of small and large scale cultures of both primary cells and cell lines. It will also provide a service for production and bulk growth of monoclonal antibodies. A pharmacology/tissue preparation module will provide eye tissues and cell preparations of reproducible quality for a number of investigators. A chemistry/molecular biology module will provide and maintain specialized shared equipment such as scintillation counters, ultracentrifuges FPLC and HPLC systems. In addition it will serve as a resource for Vision Center Investigators by providing vectors and bacterial strains as well as oligonucleotides for PCR, sequencing and binding studies.

该核心赠款的总体目标是增强视觉研究 耶鲁大学。 通过提供五个关键支持模块，该赠款将 增强个人研究人员正在进行的研究项目 提供个人无法支持的设施和专业知识 研究补助金。 模块还将有助于促进和促进 调查人员之间的协作互动并将鼓励飞行员 可以制定特定研究建议的项目。 最后，该核心赠款的模块将是一个宝贵的 耶鲁大学视觉科学培训计划的学员资源 赞助前和博士后研究员。 本应用程序中提出的特定模块包括一家机械车间 以及摄影模块，这两个模块都具有明显的功能。 一个 组织培养/杂交瘤模块将为 两者的小型和大型文化的启动和维护 原代细胞和细胞系。 它还将为 单克隆抗体的生产和大量生长。 一个 药理学/组织制备模块将提供眼组织和细胞 许多研究人员的可再现质量准备。 一个 化学/分子生物学模块将提供和维护专业 共享设备，例如闪烁计数器，超速离心FPLC 和HPLC系统。 此外，它将作为视觉的资源 中心研究人员也提供载体和细菌菌株 作为用于PCR，测序和结合研究的寡核苷酸。