CENTER FOR RESEARCH ON FERTILITY AND INFERTILITY

生育与不孕症研究中心

• 批准号: 2200838
• 负责人: FRED W TUREK
• 金额: $ 41.94万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2200838
• 关键词: biomedical facility; fertility; reproduction

This P-30 Center Core Grant application is a direct outgrowth of the research needs that have developed over the past decade of ten faculty at Northwestern University who are engaged in reproductive research in the areas of fertility and infertility. These ten investigators currently hold 21 funded NIH/NIMH research grants/projects that will access 5 scientific cores; 12 of these grants/projects are funded by the NICHD. The research programs to be served by the P-30 Center Core Grant include investigations into the neuroendocrinology of reproduction, the regulatory mechanisms of gonadal functions, the regulatory mechanisms of gametogenesis, the mechanisms of follicular selection, the ,mechanisms of action of reproductive hormones, the mechanisms regulating genital track functions and he immunological mechanisms regulating fertility. Investigators in the proposed P-30 Center Core Grant are currently addressing questions in the reproductive sciences at the biochemical, molecular, cellular, physiological and behavioral levels. The complexity of the life sciences in the area of reproductive research today requires the sharing of techniques and approaches that are often not available in a single research laboratory. Indeed, it is clear that major breakthroughs in our understanding of the reproductive system will require collaborative efforts of researchers who have expertise in diverse areas of research. Thus, this grant seeks to establish five scientific Cores which will enable Core investigators to incorporate highly sophisticated techniques into their research programs in a cost-effective manner. Furthermore, the Cores will provide quality control and technical expertise in a number of different techniques at a level normally not available to individual Investigators. The five scientific Cores to be established as part of the P-30 Core Center Grant were those that Northwestern investigators determined were in the greatest need and that would have the greatest impact on the quality of reproductive research at this University. The Cores to be established are those for Molecular Technology, Protein Analysis, In situ Hybridization, Monoclonal Antibody-Cell Culture, and Hormone and Neurotransmitter Measurements. An Administrative Core will also be established to administer the Center Grant. The establishment of this P-30 Center Core Grant will enhance the quality and cost-effectiveness of existing federally-funded research programs in the reproductive sciences, and is anticipated to lead to a better understanding of the regulatory mechanisms underlying fertility and infertility.

此 P-30 中心核心拨款申请是 P-30 中心核心拨款申请的直接产物 过去十年十位教员的研究需求 西北大学从事生殖研究 生育和不育领域。 这十名调查员 目前持有 21 项 NIH/NIMH 研究资助/项目，这些资助将 访问 5 个科学核心；其中 12 个赠款/项目由 NICHD。 P-30 中心核心拨款将服务的研究项目 包括对生殖神经内分泌学的研究， 性腺功能的调节机制 配子发生、卵泡选择机制、机制 生殖激素的作用、生殖器调节机制 追踪调节生育能力的功能和免疫机制。 拟议的 P-30 中心核心拨款的研究人员目前正在 解决生化生殖科学中的问题， 分子、细胞、生理和行为水平。 复杂性 当今生殖研究领域的生命科学需要 分享通常无法获得的技术和方法 一个单一的研究实验室。 事实上，很明显，主要 我们对生殖系统认识的突破将 需要具有专业知识的研究人员的共同努力 不同的研究领域。 因此，这笔赠款旨在建立五个 科学核心，这将使核心研究人员能够将 将高度复杂的技术融入到他们的研究项目中 具有成本效益的方式。 此外，核心将提供质量 多种不同技术的控制和技术专业知识 个别研究者通常无法达到的水平。 五个 作为 P-30 核心中心拨款的一部分，将建立科学核心 西北大学调查人员确定的那些 最大的需求，并且对质量影响最大 这所大学的生殖研究。 拟设立的核心 是分子技术、蛋白质分析、原位技术 杂交、单克隆抗体细胞培养以及激素和 神经递质测量。 行政核心也将是 成立的目的是管理中心补助金。 本次的设立 P-30 中心核心拨款将提高质量和成本效益 现有联邦资助的生殖研究项目 科学，并有望使人们更好地理解 生育和不育的调节机制。