Training Grant in Circadian and Sleep Research

昼夜节律和睡眠研究培训补助金

• 批准号: 8842169
• 负责人: FRED W TUREK
• 金额: $ 43.62万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2019-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8842169
• 关键词: Circadian Rhythms; Grant; Research; Sleep; Training

DESCRIPTION (provided by applicant): This is a resubmission of a renewal application for continued support of an established T32 Training Grant in Circadian and Sleep Research to train and support predoctoral and postdoctoral students at Northwestern University (NU) and the University of Chicago (U of C). The integration of circadian biology and sleep research in both animal models and humans has been the cornerstone of the relationship between the preceptors on this Training Grant at the U of C and NU for over 20 years, and we have added the term "circadian" to the title of our Training Program in recognition of the importance of combining these fields in the training of the next generation of young investigators. This Training Program will be led by two established senior investigators under the Multiple Leadership Plan and will involve 13 Primary Training Faculty who have their primary appointments in either basic science or clinical departments. The proposed Training Program will offer predoctoral and postdoctoral students interdisciplinary and multidisciplinary training in a wide range of scientifi disciplines that are highly relevant to understanding the function, regulation and health implications of sleep and circadian rhythmicity. Central to this Program is the training of student in modern basic science, translational research as well as patient oriented research. Multiple research perspectives have fueled for more than a decade the productive interactions and cross-fertilization that have developed between the preceptors in this Program. During the current grant period, the scope of the research activities of the Training Faculty has expanded to include bench to bedside investigations of the impact of sleep-disordered breathing on metabolism and cardiovascular function and we propose to further broaden the program in our renewed program with the addition of six outstanding physician-scientists to the training faculty. As our nation is facing unprecedented epidemics of obesity, diabetes and their cardiovascular consequences, the Training Program proposed in the present application is uniquely positioned to train an interdisciplinary workforce of academic and industry investigators as well as government decision makers to address the roles of sleep disturbances and circadian dysfunction in these public health challenges. A key feature of our Training Program is the inclusion of 10 Collaborating Faculty with additional clinical, scientific and/or educational expertise that greatly enhances our training environment, and conversely, they will benefit from their participation in the program by developing mentoring skills. Our Program will enable trainees to integrate cutting edge approaches and techniques in the areas of genetics, genomics, endocrinology, metabolism, pharmacology, neurobiology, pulmonology, cognitive neuroscience, gerontology and chronobiology into their training in sleep and circadian research. Because the preceptors in this Training Program are actively involved in research at the molecular, cellular, systems, behavioral and epidemiological levels, trainees will be trained in a rich environment of activities that are integrated together for the study of the basic mechanisms of sleep and circadian function at all levels of biological organization.

描述（由申请人提供）：这是续签申请的重新提交，以继续支持昼夜节律的T32培训补助金，并在西北大学（NU）和芝加哥大学（U of Chicago）（U of C）培训和支持培训和支持博士学位和支持博士学位。在动物模型和人类中，昼夜节律生物学和睡眠研究的整合一直是C和NU U型培训补助金的受体之间关系的基石已有20多年了，我们已经将“昼夜节律”一词添加到了我们的培训计划的标题中，以表彰在与这些领域结合这些领域的年轻调查员培训中的重要性。这个培训 计划将由两名成熟的高级调查员在多个领导计划下领导，并将涉及13位主要任命基础科学或临床部门的小学培训学院。拟议的培训计划将在广泛的科学学科中为跨学科和多学科培训提供跨学科和多学科培训，这些学科与了解睡眠和昼夜节律的功能，调节和健康含义高度相关。该计划的核心是对现代基础科学，翻译研究以及以患者为导向的研究的培训。十多年来，多种研究观点已经助长了该计划中的主持人之间发展的生产性互动和交叉侵占。在当前赠款期间，培训教师的研究活动的范围已扩大，包括对睡眠状态呼吸对代谢和心血管功能的影响的床旁调查，我们建议在我们的新计划中进一步扩大该计划，并增加了六位出色的医生对培训学院的六位出色的医师。由于我们的国家面临着肥胖，糖尿病及其心血管后果的前所未有的流行病，因此在本申请中提出的培训计划是在培训学术和行业调查人员的跨学科劳动力以及政府决策者的跨学科劳动力方面的独特定位，以及解决这些公共健康状况的影响，以应对这些公共健康状况的作用。我们的培训计划的一个关键特征是，包括10个合作教师以及其他临床，科学和/或教育专业知识，可以极大地增强我们的培训环境，相反，他们将通过开发指导技能从参与该计划中受益。我们的计划将使受训者能够将最先进的方法和技术整合在遗传学，基因组学，内分泌学，代谢，药理学，神经生物学，肺病学，认知神经科学，老年生物学和年级生物学中的培训中。由于该培训计划中的受体积极参与分子，细胞，系统，行为和流行病学水平的研究，因此学员将在丰富的活动环境中进行培训，这些活动被整合在一起，以研究在生物组织的各个层面上的基本睡眠机理和昼夜节律的基本机制。