E3Gen: Multigenerational Effects of Toxicant Exposures on Life Course Health and Neurocognitive Outcomes in the ELEMENT Birth Cohorts

E3Gen：有毒物质暴露对 ELEMENT 出生队列生命周期健康和神经认知结果的多代影响

• 批准号: 10201826
• 负责人: Karen Eileen Peterson
• 金额: $ 7.87万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10201826
• 关键词: Adolescence; Adolescent; Age; Animal Model; Attention; Barker Hypothesis; Birth; Chemical Exposure; Child; Childhood; Cohort Studies; Collaborations; Communication; Communities; Conceptions; Data; Data Analytics; Databases; Dental caries; Development; Elderly; Endocrine Disruptors; Environmental Exposure; Environmental Health; Environmental Impact; Epigenetic Process; Exposure to; Funding; Future; Generations; Germ Lines; Goals; Growth; Health; Human; Image; Individual; Infant; Institutes; Institution; Life; Life Cycle Stages; Life course epidemiology; Long-Term Effects; Maintenance; Mediating; Mediation; Menopause; Metabolic; Metabolic syndrome; Metals; Methods; Mexico; Michigan; Modeling; Monoclonal Antibody R24; Mothers; National Institute of Environmental Health Sciences; Neurocognitive; Oral health; Outcome; Parents; Participant; Perimenopause; Perinatal; Play; Pregnancy; Process; Research; Research Infrastructure; Research Personnel; Resource Sharing; Risk; Role; Secure; Techniques; Testing; Toxic Environmental Substances; Toxicant exposure; Universities; Weight Gain; Woman; Work; aged; base; biobank; cohort; data harmonization; data integration; data management; data sharing; design; developmental plasticity; disorder risk; early life exposure; epigenome; epigenomics; fluorosis; follow-up; grandparent; improved; in utero; metabolomics; microbiome; middle age; multidimensional data; next generation; novel; nutrition; oral microbiome; perinatal period; postnatal; prevent; puberty transition; recruit; search engine; senescence; toxicant; young adult

E3Gen: Multigenerational effects of toxicant exposures on life course health and neurocognitive outcomes in the ELEMENT birth cohorts SUMMARY The impact of environmental toxicants on health and disease risk during sensitive developmental periods has been recognized for nearly 20 years, as highlighted by the developmental origins of adult disease hypothesis and life course epidemiology. Yet, the potential to understand novel mechanisms implicit in these frameworks has not been fully realized. Few environmental cohorts have followed mother-child dyads beyond adolescence, precluding the ability to understand long-term impacts of toxicant exposures in young adulthood and perimenopause—both dynamic life stages characterized by increased risk of metabolic syndrome and potential changes in neurocognitive processes. The E3Gen project, based on our highly successful, 22-year research collaboration with the Instituto Nacional de Salud Pública de Mexico (INSP), comprises three birth cohorts of women originally recruited from 1994- 2004, their children now aged 12-22 years, and the next generation of grandchildren currently being born. This R24 application leverages the research infrastructure of our ongoing studies in the Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) cohorts and of three NIEHS-funded centers at the University of Michigan, creating an unparalleled opportunity launch new research that maximizes use of the existing biorepository and rich database of repeated toxicant exposures and metabolic and neurocognitive outcomes and that promotes accelerated data and resource sharing with the larger environmental health sciences community. Specific Aims are to: 1) Maintain and enhance the scientific integrity of the E3Gen multigenerational cohort and implement strategies to encourage participation and prevent loss to follow up among 850 mothers aged 38-50 years, their children aged 12-22 years, while also recruiting 90 grandchildren currently and projected to be born over the next five years; 2) Prepare for future scientific studies considering the roles of epigenetics, oral health and oral microbiome in mediating the impact of endocrine disrupting chemicals (EDCs) and metals on metabolic and neurocognitive outcomes across three generations of ELEMENT participants; 3) Develop and test novel data management techniques to improve and enrich data integration and harmonization, data sharing, and cross-project data communication.

E3Gen：有毒物质暴露对生命过程健康和神经认知的多代影响 ELEMENT 出生队列的结果 概括 环境毒物对发育敏感期健康和疾病风险的影响 近 20 年来，人们对月经的认识已经得到了认可，成人的发育起源就凸显了这一点。 然而，了解新机制的潜力。 这些框架中隐含的内容尚未得到充分实现。 青春期后的母子二元关系，妨碍了理解长期影响的能力 成年早期和围绝经期的有毒物质暴露——这两个动态生命阶段的特点是 代谢综合征的风险增加以及神经认知过程的潜在变化。 该项目基于我们与 Instituto Nacional de 22 年非常成功的研究合作 Salud Pública de Mexico (INSP) 由三个出生队列的妇女组成，最初从 1994 年开始招募 2004年，他们的孩子现在12-22岁，下一代孙辈目前正在 这个 R24 应用程序利用了我们正在进行的早期研究的研究基础设施。 墨西哥暴露于环境毒物 (ELEMENT) 队列和三名 NIEHS 资助的人员 密歇根大学的中心，为开展新研究创造了无与伦比的机会 最大限度地利用现有的生物储存库和丰富的重复毒物暴露数据库 代谢和神经认知结果，并促进加速数据和资源共享 更大的环境健康科学界的具体目标是： 1) 维持和加强。 E3Gen 多代队列的科学完整性并实施鼓励的策略 850名38-50岁的母亲及其子女的参与和防止失访 12-22岁，同时目前还招募90名孙辈，预计将在未来五年内出生 2) 为未来的科学研究做好准备，考虑表观遗传学、口腔健康和口腔的作用 微生物组介导内分泌干扰化学物质 (EDC) 和金属对代谢的影响 以及三代 ELEMENT 参与者的神经认知结果；3) 开发和测试 新颖的数据管理技术，以改进和丰富数据集成和协调、数据 共享和跨项目数据通信。