On Demand Removal of Oral Biofilms via Photresponsive Coatings

通过光响应涂层按需去除口腔生物膜

• 批准号: 10171403
• 负责人: Devatha P. Nair
• 金额: $ 16.4万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10171403
• 关键词: Adhesions; Affect; Anti-Bacterial Agents; Anti-Infective Agents; Area; Aspiration Pneumonia; Bacterial Adhesion; Behavior; Biocompatible Materials; Biomedical Research; Bioreactors; Cardiovascular Diseases; Cause of Death; Colorado; Consult; Dental; Dental Enamel; Dental Plaque; Dental Schools; Dental Students; Dental caries; Development; Development Plans; Doctor of Philosophy; Educational process of instructing; Engineering; Ensure; Environment; Esthetics; Excision; Exposure to; Extramural Activities; Faculty; Failure; Fatigue; Funding; Gingiva; Goals; Growth; Home; Human; Image; Immunology; International; Journals; Light; Mechanics; Medical; Medicine; Mentors; Methacrylates; Microbial Biofilms; Microbiology; Modeling; Molecular Conformation; Montana; Nosocomial Infections; Oral cavity; Pathologic; Pattern; Performance; Polymers; Pregnancy Complications; Prevention; Pseudomonas aeruginosa; Regimen; Research; Research Activity; Research Personnel; Research Project Grants; Research Training; Residual state; Resistance; Risk; Saliva; Scheme; Scientist; Series; Stress; Structure; Surface; Systemic disease; Texture; Tooth structure; Training; Ultraviolet Rays; United States National Institutes of Health; Universities; Visible Radiation; Work; azobenzene; base; biomaterial compatibility; career development; cis trans isomerization; combat; composite restoration; controlled release; dental biofilm; design; materials science; mechanical behavior; meetings; microorganism; non-Native; novel strategies; oral biofilm; oral care; patient home care; phase change; photopolymerization; prevent; professor; programs; response; restoration; restorative composite; restorative dentistry; restorative material; skill acquisition; skills; tenure track; triethylene glycol dimethacrylate

CANDIDATE: Devatha P. Nair, Ph.D., is an Assistant Professor and a materials science researcher in the School of Dental Medicine at the University of Colorado-Anschutz Medical Campus. Dr. Nair’s K25 application proposes to engineer a photo-responsive coating that can enable ‘on-demand’ oral biofilm removal from the surface of a composite restorative material while maintaining the aesthetic and functional aspects of the underlying material. Her immediate goal is to acquire the research training and professional skills necessary to transition to an independent investigator. Her long-term goal is to develop an independent, extramurally funded research program by becoming a successful, effective tenure-track faculty who can fully engage with dental students and residents through teaching and research activities in the field of dental biomaterials. CAREER DEVELOPMENT PLAN: Dr. Nair’s career development training consists of: 1) acquiring new experimental skills and approaches to strengthen her research plan. 2) further training in culturing, analyzing and imaging oral biofilms in a variety of static and flow-through reactors. 3) refinement of professional skills development including formal course work, attendance and presentations at weekly journal clubs, university seminars, national scientific meetings, as well as regular meetings with Dental Biomaterials Journal club (weekly); Dept. of Immunology and Microbiology seminar series (Friday Seminar Series-weekly);and 4) through regular interactions with her mentoring team. ENVIRONMENT: The environment for Dr. Nair’s training plan will be outstanding. The principal mentor, Dr. Jeffrey Stansbury is an internationally recognized NIH-funded scientist. Along with co-mentor Dr. Schurr and secondary mentors, Drs. Pfeifer and Zajdowicz and consulting mentor Dr. Jack Ferracane, a strong, inter- disciplinary mentoring team in biomedical research has been assembled. Additionally, regular input from experts such as Dr. Michael Franklin (Center for Biofilm Engineering -Montana State University) and Dr. Noel Clark (Director, Soft Matter Materials Research Center at UC-Boulder) will ensure that Dr. Nair will have access to specific expertise in key areas of her research project and overall training plan. RESEARCH: There is a growing need to develop strategies to both understand and disrupt the growth and retention of dental biofilms that can cause secondary caries and a host of systemic diseases such as aspiration pneumonia, cardiovascular disease and complications during pregnancy. This proposal aims to develop strategies to combat biofilm growth and to prevent the progression of dental caries. Working on the premise that a long-term and effective solution towards the removal of oral biofilms relies on a dynamic, photo-responsive coating that can repeatedly and efficiently disrupt oral biofilm attachment, the proposal aims to develop photo- responsive coatings on the surface of restoratives that can repeatedly and reliably be called upon to physically disrupt and dislodge biofilms.

候选人：Devatha P. Nair 博士，该学院助理教授和材料科学研究人员 科罗拉多大学安舒茨医学院牙科医学系 Nair 博士的 K25 申请建议。 设计一种光响应涂层，可以“按需”去除口腔生物膜 复合修复材料，同时保持底层材料的美观和功能。 她的近期目标是获得过渡到大学所需的研究培训和专业技能。 她的长期目标是开展一项独立的、外部资助的研究。 计划成为一名成功、高效的终身教职人员，能够与牙科学生充分互动， 居民通过牙科生物材料领域的教学和研究活动。 职业发展计划：Nair 博士的职业发展培训包括： 1) 获得新的知识 加强她的研究计划的实验技能和方法 2) 培养、分析方面的进一步培训。 以及在各种静态和流通反应器中对口腔生物膜进行成像 3）专业技能的完善。 发展包括正式课程作业、出席每周期刊俱乐部、大学并进行演讲 研讨会、全国科学会议以及牙科生物材料期刊俱乐部的定期会议 （每周）；免疫学和微生物学系研讨会系列（周五研讨会系列-每周）；以及 4) 通过 与她的指导团队定期互动。 环境：奈尔博士的培训计划环境非常好。 杰弗里·斯坦斯伯里 (Jeffrey Stansbury) 是一位国际公认的美国国立卫生研究院 (NIH) 资助的科学家，他的共同导师是舒尔博士 (Dr. Schurr) 和 二级导师 Pfeifer 和 Zajdowicz 博士以及咨询导师 Jack Ferracane 博士，一位强大的、国际化的 此外，还组建了生物医学研究学科指导团队，定期听取专家的意见。 例如Michael Franklin博士（蒙大拿州立大学生物膜工程中心）和Noel Clark博士 （加州大学博尔德分校软物质材料研究中心主任）将确保奈尔博士能够获得 她的研究项目和总体培训计划的关键领域的具体专业知识。 研究：越来越需要制定战略来理解和破坏增长和 牙齿生物膜的保留可能导致继发性龋齿和许多系统性疾病，例如误吸 该提案旨在发展妊娠期肺炎、心血管疾病和并发症。 对抗生物膜生长和预防龋齿进展的策略。 去除口腔生物膜的长期有效解决方案依赖于动态的光响应 涂层可以重复有效地破坏口腔生物膜附着，该提案旨在开发光- 修复体表面的响应涂层可以重复可靠地进行物理修复 破坏和去除生物膜。