Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System

模型昆虫系统中嗅觉驱动的攻击性和社会等级的分子神经遗传学

基本信息

批准号：
10170383
负责人：
LAURENCE J ZWIEBEL
金额：
$ 31.39万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-16 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10170383
关键词：
Adult Aggressive behavior Animal Model Animals Ants Automobile Driving Behavior Behavioral Behavioral Model Behavioral Paradigm Behavioral Research Biological Assay Biological Models Brain Castes Chemicals Clustered Regularly Interspaced Short Palindromic Repeats Collection Communication Complex Data Set Drosophila melanogaster Economics Ethics Exhibits Family Female Florida Gene Targeting Gland Hemolymph Human Hydrocarbons Individual Insecta Knock-out Light Link Mammals Mediating Messenger RNA Modeling Molecular Neuraxis Neurobiology Neuronal Plasticity Neuropeptides Odorant Receptors Olfactory Pathways Pathway interactions Pattern Peripheral Pheromone Pheromone Receptors Police Primates Proteomics Publishing RNA Interference Research Role Smell Perception Social Behavior Social Hierarchy Social status Sterility System Tachykinin Testing Transgenic Organisms Triad Acrylic Resin base behavioral plasticity behavioral response behavioral study bioinformatics pipeline gain of function human model loss of function male mutant neurogenetics neuropeptide F programs receptor reproductive response social synthetic peptide transcriptome sequencing transcriptomics

项目摘要

Project Summary Humans and many other animals exhibit a wide variety of social behaviors. Traditionally, primates have been used as research models of human behavior due to their close evolutionary relationship to humans and their highly social behavior. However, the use of primates for such research has significant economic, practical, and ethical drawbacks, and, in that light, it would be useful to find other models for behavioral studies that exhibit complex social behaviors. One potential model that fits both criteria is the extensive family of insects collectively known as the ants, some species of which exhibit highly complex “eusocial” behaviors involving a strict division of labor between sterile workers and reproductive queens. Among ant workers, there is a further division of labor, with different tasks allocated among different castes of workers. Our hypothesis is that caste/colony-specific aggression and social hierarchy reflect and in-part are determined by chemosensory programs dictated largely through odorant receptors and shifts in neuropeptidomic profiles. We will investigate this question in two ant species—Camponotus floridanus and Harpegnathos saltator—that exist in large colonies that are composed of just a few males, and the remainder are females, including one (typically) queen, and numerous workers that engage in caste/colony specific aggressive behaviors such as defense, policing and dueling.

项目概要传统上，人类和许多其他动物表现出各种各样的社会行为。由于它们与人类及其动物的密切进化关系，被用作人类行为的研究模型然而，利用灵长类动物进行此类研究具有重大的经济性、实用性和价值。道德动摇，从这个角度来看，找到其他表现出行为研究的模型将是有用的符合这两个标准的一种潜在模型是广泛的昆虫家族。统称为蚂蚁，其中一些物种高度表现出复杂的“真社会”行为，涉及不育工蚁和繁殖蚁后之间有严格的分工。劳动分工，不同种姓的工人分配不同的任务。我们的假设是，种姓/殖民地特有的攻击性和社会等级制度反映并部分确定化学感应程序主要通过气味受体和神经肽组学的变化来决定。我们将在两种蚂蚁（Camponotus floridanus 和 Harpegnathos salator）中研究这个问题。存在于仅由少数雄性组成的大型群体中，其余都是雌性，其中包括一只（典型的）女王，以及许多从事种姓/殖民地特定攻击行为的工人，例如防御、治安和决斗。

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Olfactory sensitivity differentiates morphologically distinct worker castes in Camponotus floridanus.

嗅觉敏感性区分了佛罗里达弓背蚁形态上不同的工蚁种姓。

DOI：
发表时间：
2023-01-08
期刊：
影响因子：
5.4
作者：
Ferguson, S T;Bakis, I;Edwards, N D;Zwiebel, L J
通讯作者：
Zwiebel, L J

Age and Task Modulate Olfactory Sensitivity in the Florida Carpenter Ant Camponotus floridanus.

年龄和任务调节佛罗里达木蚁 Camponotus floridanus 的嗅觉敏感性。

DOI：
发表时间：
2023-08-23
期刊：
影响因子：
3
作者：
Ferguson, Stephen T;Bakis, Isaac;Edwards, Nicholas D;Zwiebel, Laurence J
通讯作者：
Zwiebel, Laurence J

Odor coding of nestmate recognition in the eusocial ant Camponotus floridanus.

真社会性蚂蚁 Camponotus floridanus 中巢友识别的气味编码。

DOI：
发表时间：
2020-01-28
期刊：
影响因子：
0
作者：
Ferguson, Stephen T;Park, Kyu Young;Ruff, Alexandra A;Bakis, Isaac;Zwiebel, Laurence J
通讯作者：
Zwiebel, Laurence J

Antennal Olfactory Physiology and Behavior of Males of the Ponerine Ant Harpegnathos saltator.

雄性 Ponerine Ant Harpegnathos 跳跃者的触角嗅觉生理学和行为。

DOI：
发表时间：
2018-11
期刊：
影响因子：
2.3
作者：
Ghaninia, Majid;Berger, Shelley L;Reinberg, Danny;Zwiebel, Laurence J;Ray, Anandasankar;Liebig, Jürgen
通讯作者：
Liebig, Jürgen

Advances in the Study of Olfaction in Eusocial Ants.

真社会性蚂蚁嗅觉研究进展。