PATHOGENESIS OF HYPERCALCEMIA

高钙血症的发病机制

• 批准号: 2140708
• 负责人: MARK LEPPERT
• 金额: $ 25.72万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-11-01 至 1997-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2140708
• 关键词: PATHOGENESIS; HYPERCALCEMIA

项目成果

Calcium infusion suggests a "set-point" abnormality of parathyroid gland function in familial benign hypercalcemia and more complex disturbances in primary hyperparathyroidism.

• DOI: 10.1210/jcem.76.3.8445032
• 发表时间: 1993-03
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: S. Khosla;P. Ebeling;A. Firek;M. F. Burritt;P. Kao;H. Heath

Familial benign hypercalcemia--from clinical description to molecular genetics.

家族性良性高钙血症——从临床描述到分子遗传学。

• 发表时间: 1994
• 期刊: The Western journal of medicine
• 作者: Heath3rd,H

Plasma intact parathyroid hormone (PTH) and PTH-related peptide in familial benign hypercalcemia: greater responsiveness to endogenous PTH than in primary hyperparathyroidism.

家族性良性高钙血症中的血浆完整甲状旁腺激素 (PTH) 和 PTH 相关肽：与原发性甲状旁腺功能亢进症相比，对内源性 PTH 的反应性更大。

• DOI: 10.1210/jcem-72-3-541
• 发表时间: 1991
• 期刊: The Journal of clinical endocrinology and metabolism
• 作者: Firek,AF;Kao,PC;Heath3rd,H
• 通讯作者: Heath3rd,H

Desensitization of rat osteoblast-like cells (ROS 17/2.8) to parathyroid hormone uncouples the adenosine 3',5'-monophosphate and cytosolic ionized calcium response limbs.

大鼠成骨细胞样细胞 (ROS 17/2.8) 对甲状旁腺激素的脱敏使 3,5-单磷酸腺苷和胞质离子钙反应四肢解偶联。

• DOI: 10.1210/endo-128-2-1021
• 发表时间: 1991
• 期刊: Endocrinology
• 影响因子: 4.8
• 作者: Bidwell,JP;Fryer,MJ;Firek,AF;Donahue,HJ;Heath3rd,H
• 通讯作者: Heath3rd,H

Genetic abnormalities in sporadic parathyroid adenomas: loss of heterozygosity for chromosome 3q markers flanking the calcium receptor locus.

散发性甲状旁腺腺瘤的遗传异常：钙受体基因座侧翼的染色体 3q 标记杂合性丧失。

• DOI: 10.1210/jcem.80.11.7593455
• 发表时间: 1995
• 期刊: The Journal of clinical endocrinology and metabolism.
• 作者: Thompson,DB;Samowitz,WS;Odelberg,S;Davis,RK;Szabo,J;Heath3rd,H
• 通讯作者: Heath3rd,H