Investigating the impact of helminth infection on microbioma composition and innate immunity generated during HepB vaccination.

研究蠕虫感染对乙型肝炎疫苗接种过程中微生物群组成和先天免疫的影响。

• 批准号: 10163555
• 负责人: Rafick Pierre Sekaly
• 金额: $ 31.15万
• 依托单位: DREXEL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-29 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10163555
• 关键词: Administrative Supplement; Biological; Biological Assay; COVID-19; Clinical; Clinical Data; Cohort Studies; Data; Disease Progression; Goals; Image; Immune System Diseases; Immune response; Immunophenotyping; Infection; Irrigation; Knowledge; Laboratories; Leadership; Natural Immunity; Ohio; Pennsylvania; Peripheral Blood Mononuclear Cell; Phenotype; Reading; Sampling; Specimen; Sputum; Standardization; Testing; Universities; Vaccination; Viral Pathogenesis; Virus; cohort; coronavirus disease; helminth infection; immunological status; programs; sample collection

Summary: The goal of the Administrative Supplement is to provide a central rich store of data and specimens from two independent cohorts located in Reading, Pennsylvania and Cleveland, Ohio. The samples and the clinical data will be distributed to the central cores assigned by the program where standardized phenotypic assays will be performed. General leadership of the Cores will be provided by Dr. Charles Cairns from Drexel University for the Reading cohort and Dr. Benigno from Case Western Reserve University. There are 3 aims of this Administrative supplement. Specific Aim 1: To provide biological specimens (PBMCs, sputum, and lavages) to all our designated cores in order to characterize the immunophenotypes and the immune status and response to COVID-19 infection. Specific Aim 2: To provide clinical data (CBC counts, clinical tests, imaging) to all our designated cores in order to establish correlation with immune status and disease progression Specific Aim 3: To provide biological specimens and clinical data to our assigned laboratories at Drexel and Case Western Universities. These laboratories will perform unique assays that are not covered by the core laboratories of the program.

概括： 行政补充文件的目标是提供丰富的数据和样本的中央存储 来自宾夕法尼亚州雷丁和俄亥俄州克利夫兰的两个独立队列。这 样本和临床数据将分发到程序指定的中央核心 将进行标准化表型测定。核心的总体领导将是 由德雷克塞尔大学的 Charles Cairns 博士和 Benigno 博士为雷丁队提供 来自凯斯西储大学。 本行政补充文件有 3 个目的。 具体目标 1：向我们所有的人员提供生物标本（PBMC、痰液和灌洗液） 指定核心以表征免疫表型和免疫状态， 对 COVID-19 感染的反应。 具体目标 2：向我们指定的所有人员提供临床数据（CBC 计数、临床测试、影像） 核心以建立与免疫状态和疾病进展的相关性 具体目标 3：向我们指定的实验室提供生物样本和临床数据 德雷克塞尔大学和凯斯西储大学。这些实验室将进行独特的检测，这些检测不是 由该计划的核心实验室涵盖。