Emory/Georgia TB Research Advancement Center (TRAC)

埃默里/佐治亚州结核病研究促进中心 (TRAC)

基本信息

批准号：
10429404
负责人：
Rafick Pierre Sekaly
金额：
$ 19.73万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-23 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10429404
关键词：
ATAC-seq Address Area Basic Science Bioinformatics Biological Assay Biological Markers Cells Cellular Indexing of Transcriptomes and Epitopes by Sequencing Clinical Clinical Sciences Communicable Diseases Communities Complex Computational Biology Computer Models Consult Consultations Core Facility Data Data Analyses Data Set Development Diagnosis Disease Disease Progression Doctor of Philosophy Education Educational workshop Environment Experimental Designs Faculty Flow Cytometry Fostering Functional disorder Funding Genes Genomics Immune Evasion Immunity Immunology Immunology procedure Individual Infrastructure Institution Intake Interdisciplinary Study Investigation Knowledge Laboratories Lead Leadership Measurement Mentorship Metabolic Pathway Methods Modeling Multiomic Data Pathway Analysis Postdoctoral Fellow Prevention Records Research Research Design Research Personnel Research Training Resolution Resource Sharing Resources Services Structure System Systems Biology Technology Tissues Training Translational Research Tuberculosis United States National Institutes of Health World Health Organization computational pipelines cytokine data acquisition data integration education resources epigenomics experimental study graduate student high dimensionality innovation lipidome lipidomics member metabolic phenotype metabolome metabolomics microbiome analysis multidimensional data multiple omics multiscale data next generation novel single cell technology tool transcriptome sequencing transcriptomics uptake

项目摘要

The Bioinformatics and Integrated Systems Biology (Systems Biology) Core will represent an integral component of the Emory/Georgia TRAC. While individual members of the Emory/Georgia TB research community have strong records of collaborative TB research, access to cutting edge methods in systems biology have not been easily accessible. Although the partner institutions of the Emory/Georgia TRAC host a wide variety of Core facilities performing ‘-omics’ assays, expertise in computational biology needed to analyze and integrate the high-dimensional, multiscale data sets produced by these platforms is often not readily available. We propose to provide essential support for high-dimensional, multiscale data analysis and integration to facilitate use of ‘-omics’ technologies among Emory/Georgia TRAC investigators. The Systems Biology Core will accomplish this by serving as a single point of contact (concierge function) to investigators of the Emory/Georgia TRAC, and facilitating access to a wide array of ‘-omics’ technologies for specific experimental designs. Using established computational pipelines, we will provide training to new investigators on methods in high-dimensional data analysis and data integration in this increasingly essential area of basic and translational research. The specific aims of the BISB Core are: 1) to provide a single point of contact structure for data acquisition, management, and analysis for all ‘-omics’ platforms to TRAC investigators; 2) To provide training and educational resources to TRAC members to carry out cutting edge experiments using ‘- omics’ technologies and implement associated computational pipelines; and 3) to develop and implement novel multiomics assays and associated computational models to advance TB research. We will strive to nurture a collaborative research environment among Emory/Georgia TRAC investigators by facilitating the use and implementation of cutting edge multiomics assays to advance TB research and train the next generation of TB researchers.

生物信息学和综合系统生物学（系统生物学）核心将代表一个完整的埃默里/佐治亚州 TRAC 的组成部分，同时也是埃默里/佐治亚州结核病研究的个人成员。社区拥有协作结核病研究的良好记录，可以使用系统中的尖端方法尽管埃默里/佐治亚州 TRAC 的合作机构主办了一个执行“组学”分析的各种核心设施，分析所需的计算生物学专业知识并整合这些平台产生的高维、多尺度数据集通常并不容易获得我们建议为高维、多尺度数据分析和提供必要的支持。整合以促进埃默里/佐治亚州 TRAC 系统研究人员使用“组学”技术。 Biology Core 将通过充当研究人员的单一联络点（礼宾功能）来实现这一目标埃默里/佐治亚州 TRAC，并促进特定人群获得广泛的“组学”技术实验设计。使用已建立的计算管道，我们将为新研究人员提供培训。在这个日益重要的基础领域中高维数据分析和数据集成的方法 BISB 核心的具体目标是： 1) 提供单一联络点。为 TRAC 研究人员提供所有“组学”平台的数据采集、管理和分析的结构；为 TRAC 成员提供培训和教育资源，以使用“-”进行前沿实验 omics 的技术并实施相关的计算管道；以及 3) 开发和实施我们将努力开发新型多组学检测和相关计算模型来推进结核病研究。通过促进使用，在埃默里/佐治亚州 TRAC 研究人员之间培育协作研究环境并实施尖端的多组学检测，以推进结核病研究并培训下一代结核病研究人员。