SPATIAL INFLUENCES ON LANGUAGE FUNCTION

空间对语言功能的影响

• 批准号: 2128256
• 负责人: H BRANCH COSLETT
• 金额: $ 14.97万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-30 至 1998-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2128256
• 关键词: attention; auditory stimulus; brain imaging /visualization /scanning; brain interhemispheric activity; cognition; human subject; judgment; language; neural information processing; neuroanatomy; neuropsychological tests; performance; psycholinguistics; psychomotor reaction time; reading; semantics; space perception; speech; stimulus /response; stroke; visual fixation; visual stimulus

The purpose of the studies proposed here is to provide evidence for spatial influences on language function and to explore the anatomic and functional bases of these effects. In Part 1, subjects with single hemispheric infarctions will be tested on a battery of language tasks in which the location to which they attend will be systematically manipulated. Objectives of this component of the investigation are to determine the prevalence of spatial effects on language function and to define the anatomic bases of these effects by correlating performance with lesion site as defined by neuro-imaging studies. Those patients who demonstrate significant spatial effects on this test battery will serve as subjects in a second series of studies aimed at defining the mechanisms that underlie these effects. These studies, motivated by our provisional account of spatial effects on cognitive function (the spatial registration hypothesis), will examine the integrity of mechanisms involved in spatial representation and attention. In Part 2 we propose to examine spatial effects in normal language processing. In addition to providing converging evidence for spatial influences on language function and establishing the domain over which such influences apply, these studies will help to constrain interpretation of the data from studies of brain lesioned subjects in Part 1. The proposed investigations have both clinical and theoretical significance. From a theoretical standpoint, these studies should increase our understanding of the role of spatial information in maintaining distributed brain systems in registration, as well as of the brain mechanisms that support this binding function. The potential clinical significance of this work is also clear. If patients with brain injury do indeed demonstrate significant spatial effects in language processing, it may be possible to improve patients' functional capacity simply by controlling the site and/or side to which they attend or act.

这里提出的研究的目的是为 空间影响语言功能并探索解剖和 这些效应的功能基础。 在第1部分中，将测试具有单半球梗塞的受试者 在一系列语言任务上，他们参加的位置 将被系统地操纵。该组件的目标 调查是为了确定空间影响的患病率 语言功能并通过 通过神经成像定义的病变部位将性能与病变部位相关联 研究。那些对空间作用显着影响的患者 该测试电池将在第二系列研究中充当主题 旨在定义这些作用的基础的机制。这些 研究，我们对空间影响的临时描述的动机 认知功能（空间注册假设）将检查 空间表示和 注意力。在第2部分中，我们建议检查正常的空间效应 语言处理。除了提供融合的证据 空间影响语言功能并建立域 这种影响适用，这些研究将有助于约束 解释来自大脑病变受试者研究的数据 第1部分。 拟议的调查既有临床和理论 意义。从理论的角度来看，这些研究应该 提高我们对空间信息在中的作用的理解 在注册中维护分布式大脑系统以及 支持这种结合功能的大脑机制。潜力 这项工作的临床意义也很明显。如果大脑患者 伤害确实表现出语言的显着空间效应 处理，可能有可能提高患者的功能能力 只需控制他们参加或采取行动的站点和/或侧面即可。