AUDITORY ASSESSMENT WITH AEPS IN CHILDREN

儿童 AEPS 听觉评估

• 批准号: 2126543
• 负责人: NINA KRAUS
• 金额: $ 20.94万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-07-01 至 1996-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2126543
• 关键词: academic achievement; attention deficit disorder; auditory discrimination; auditory threshold; behavior test; child (0-11); diagnosis design /evaluation; electroencephalography; evoked potentials; hearing disorders; hearing tests; human subject; learning disorders; neural information processing; psychoacoustics; sensorineural hearing loss; sleep; speech; speech synthesizers

The overall goal of this investigation is to improve the diagnosis of hearing loss and central auditory deficits in young children. The use of certain auditory evoked potentials (AEPs), including middle latency (MLR) and late potentials, has been limited in pediatric populations because of the variability of these responses during sleep or the dependence of the responses on a behavioral task which may be beyond the capabilities of a young child. This project is an investigation of the MLR and mismatch negativity (MMN) AEPs in children and addresses how these limitations may be overcome. The first major aim is to develop a means to identify the periods during sleep that are favorable for recording the MLR. Previous research has indicated that certain sleep stages are more favorable than others and that they may be distinguished by analyzing the EEG for specific amplitude and frequency characteristics. Proposed is an investigation of the utility of the "delta ratio", a measure of the dominance of delta activity in the EEG. On-line detection of delta presence/absence could signal a clinician or researcher when a child is in a favorable MLR recording period. Similar measures could eventually be applied to other AEPs. A second major aim is to characterize the MMN in response to well-defined speech stimuli to determine if this response can provide an objective neurophysiologic measure of auditory discrimination in school-aged children. The MMN reflects central auditory processing of small acoustic differences and does not depend on active participation from the child. The MMN will be elicited by synthesized speech stimuli that differ in acoustic parameters that are fundamental to speech perception. Another objective is to determine whether developmental changes in the MLR and the MMN correlate with behavioral measures of development as determined by standardized measures of mental aptitude and processes underlying learning and academic achievement. Clinical applicability of the combined electrophysiologic/behavioral approach will be evaluated in (1) children with behaviorally identified central auditory deficits and (2) children with attention deficit hyperactivity disorder -- a group in which the co-existence of auditory processing deficits is well established.

这项研究的总体目标是改善诊断 幼儿听力损失和中枢听觉缺陷。 用途 某些听觉诱发电位 (AEP)，包括中潜伏期 （MLR）和晚期潜力，在儿科人群中受到限制 由于这些反应在睡眠期间或 反应对行为任务的依赖性可能超出了 幼儿的能力。 该项目是一项调查 儿童中的 MLR 和失配阴性 (MMN) AEP 并解决了如何 这些限制是可以克服的。 第一个主要目标是开发一种方法来识别期间的各个时期 有利于记录 MLR 的睡眠。 先前的研究有 表明某些睡眠阶段比其他阶段更有利并且 可以通过分析脑电图的特定情况来区分它们 幅度和频率特性。 建议进行调查 “德尔塔比率”的效用，衡量德尔塔主导地位的指标 脑电图活动。 在线检测三角洲存在/不存在可以 当孩子处于有利的 MLR 时，向临床医生或研究人员发出信号 录音期间。 类似的措施最终可能适用于其他地区 AEP。 第二个主要目标是根据明确定义的 MMN 来表征 言语刺激以确定该反应是否可以提供客观的 学龄儿童听觉辨别的神经生理学测量 孩子们。 MMN 反映了小声音的中枢听觉处理 差异并不取决于孩子的积极参与。 MMN 将由不同的合成语音刺激引发 语音感知的基础声学参数。 其他 目的是确定 MLR 和 MLR 的发育变化是否 MMN 与所确定的发展行为测量相关 通过心理能力和潜在过程的标准化测量 学习和学术成就。 临床适用性 电生理/行为联合方法将在 (1) 中进行评估 行为上发现中枢听觉缺陷的儿童和 (2) 患有注意力缺陷多动障碍的儿童——一组 听觉处理缺陷的共存是很好的 已确立的。