EPIDEMIOLOGY OF EPITHELIAL OVARIAN CANCER

上皮性卵巢癌的流行病学

• 批准号: 2101855
• 负责人: KARIN A ROSENBLATT
• 金额: $ 32.82万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-15 至 1998-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2101855
• 关键词: African American; body physical activity; cancer risk; caucasian American; diet; fallopian tube surgery; family genetics; female; fertility; hormone therapy; human subject; hysterectomy; interview; neoplasm /cancer epidemiology; nutrition related tag; oral contraceptives; ovary neoplasms; particle; questionnaires; racial /ethnic difference; statistics /biometry

A population-based case-control study of epithelial ovarian cancer, which will investigate the association between genital talc use, infertility, infertility treatments, hormone use, oral contraceptive use, gynecologic operations, nutritional factors and physical activity and the development of epithelial ovarian cancer is proposed. The study will be performed in the multi-ethnic, multi-racial community of Cook County, Illinois. Approximately 750 incident epithelial ovarian cancer cases occurring in this community will be ascertained over a three year period. Histologic specimens obtained during diagnostic operation of the case will be evaluated by the study pathologist to consistently classify histologic subtype and degree of malignancy. Approximately 1500 population controls, matched on age and race, will be ascertained using random digit dialing (less than age 65) and lists of medicare recipients maintained by the Health Care Financing Administration (age 65 or higher). Etiologic information will be ascertained using a self-administered food-frequency questionnaire and an in-person interview. Analyses will be performed using conditional logistic regression and polychotomous logistic regression.

一项基于人群的上皮性卵巢癌病例对照研究， 将调查生殖器滑石粉使用与不孕症之间的关联， 不孕症治疗、激素的使用、口服避孕药的使用、妇科 操作、营养因素和体力活动以及发育 提出了上皮性卵巢癌。该研究将在 伊利诺伊州库克县的多民族、多种族社区。 大约 750 起上皮性卵巢癌病例发生在 该社区将在三年内确定。组织学 病例诊断操作期间获得的标本将 由研究病理学家评估以一致地对组织学进行分类 亚型和恶性程度。大约1500个人口控制， 年龄和种族相匹配，将使用随机数字拨号来确定 （65岁以下）以及由医疗保险机构维护的医疗保险受益人名单 医疗保健融资管理局（65 岁或以上）。病因学 将使用自我管理的食物频率来确定信息 问卷调查和面对面访谈。分析将使用 条件逻辑回归和多分类逻辑回归。