Polybrominated Biphenyls and Cancer Risk

多溴联苯与癌症风险

• 批准号: 7319548
• 负责人: KARIN A ROSENBLATT
• 金额: $ 7.3万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7319548
• 关键词: Affect; Blood specimen; Breast; Cessation of life; Cheek structure; Collection; Confounding Factors (Epidemiology); County; Data; Data Set; Disease regression; Dose; Endocrine disruption; Epidemiology, Other; Female; Female Breast Carcinoma; Flame Retardants; Food; Food Supply; Genetic Polymorphism; Hormones; Incidence; Interview; Investigation; Link; Malignant Neoplasms; Malignant neoplasm of prostate; Measurement; Medical Surveillance; Michigan; Nested Case-Control Study; Numbers; Participant; Persons; Polybrominated Biphenyls; Polychlorinated Biphenyls; Population; Property; Prostate; Public Health; Purpose; Range; Rate; Registries; Relative Risks; Research; Risk; Role; Rural; Sampling; Serum; Site; Structure; Swab; Thinking; Time; Woman; base; cancer risk; cancer site; cancer type; case control; cohort; design; hormone related cancer; malignant breast neoplasm; member; men; organochlorine pesticide; phenyl ether; response

DESCRIPTION (provided by applicant): The purpose of this study is to investigate the cancer risk in Michigan residents who were exposed to varying (including high) levels of polybrominated biphenyls (PBBs - a fire retardant) from 1973-74 through an accidental exposure in food. PBBs may have endocrine disrupting potential and other environmentally persistent organohalogens such as polybrominated diphenyl ether (PBDEs), polychlorinated biphenyls (PCBs), and organochlorine pesticides (such as DDT and DDE) have also been thought to have this property. These compounds may affect cancer risk, as has been suggested by an initial finding of a nonsignificant increase in breast cancer risk in the Michigan PBB Cohort and other epidemiologic study results. This study will utilize an epidemiologic cohort design to determine whether PBBs increase the risk of cancers at specific sites and whether there is a dose-response relationship between serum PBB levels and the relative risk of site-specific cancers. The participants in this study had serum PBB measurements obtained shortly after the accidental exposure and at later times. Cancer incidence in the cohort will be determined by linking to the Michigan Cancer and Death Registries. The first specific aim of this investigation is to determine whether the observed number of primary cancers at specific and grouped cancer sites in the cohort, are higher than expected based on (i) rates in rural Michigan counties where cohort members resided and (ii) national rates using data from the Surveillance, Epidemiology, and End Results Registries (SEER) by calculating standardized incidence ratios (SIRs). Secondly, we will determine whether the risk of common cancers is increased in subjects in the cohort who have higher baseline serum PBB levels using Poisson Regression. In addition, we will determine whether the risk of breast and prostate cancer is related to baseline serum PBB levels using nested case-control designs. In the breast cancer nested case-control study, we will utilize two additional data sets to determine whether additional variables may confound the PBB-breast cancer relationship. Furthermore, if significant, the results of the proposed project will serve as pilot data for expanded, mechanism-focused nested case-control studies of breast, prostate, or other cancers displaying an association with PBB exposure. These studies could involve performing in-person interviews and obtaining biologic samples (such as blood samples or cheek swabs) to determine the mechanism of a potential carcinogenic effect. This proposed study will provide information on the potential carcinogenic effects of a range of exposure levels to an organohalogen (PBBs) in a well-characterized cohort population. Information from this investigation can be applied to research on other environmentally persistent organohalogens with similar structures which are of public health concern, such as PCBs, DDT/DDE, and brominated flame retardants (PBDEs).

描述（由申请人提供）： 这项研究的目的是调查密歇根州居民的癌症风险，他们从1973 - 74年间暴露于1973 - 74年的多溴二苯基（包括高）多溴的双苯基（PBBS-阻燃剂）。 PBB可能具有内分泌破坏的潜力和其他环境持续的有机催化剂，例如聚溴的二苯基醚（PBDES），多氯联苯（PCB）和有机氯农药（例如DDT和DDE），也已被认为也已被认为具有此特性。这些化合物可能会影响癌症风险，正如最初发现密歇根州PBB队列中乳腺癌风险无显着增加和其他流行病学研究结果的最初发现所表明的。这项研究将利用流行病学队列设计来确定PBB是否会增加特定部位的癌症的风险，以及血清PBB水平和相对特异性癌症的相对风险之间是否存在剂量反应关系。这项研究的参与者在意外暴露和以后的时间后不久就获得了血清PBB测量值。该队列中的癌症发病率将通过与密歇根州癌症和死亡登记处联系起来确定。这项研究的第一个具体目的是确定同类群体中特定和分组的癌症部位观察到的主要癌症数量是否高于预期的基于密歇根州农村县（i）的速率，在该县的（i）中，同类成员使用监测，流行病学和最终结果（SEER（SEER）（SEER）通过计算标准的标准标准认心率（SIRSIDISE SIRSID SIRSIDISE）使用来自监测，流行病学和最终结果的数据，该率是（ii）国家速率。其次，我们将确定使用Poisson回归具有较高基线血清PBB水平的受试者中普通癌的风险是否增加。此外，我们将使用嵌套的病例对照设计确定乳腺癌和前列腺癌的风险是否与基线血清PBB水平有关。在乳腺癌嵌套的病例对照研究中，我们将利用两个其他数据集来确定其他变量是否会混淆PBB-乳腺癌的关系。此外，如果重要的话，提议的项目的结果将作为乳腺癌，前列腺或其他癌症的扩展，以机制为中心的嵌套病例对照研究，以显示与PBB暴露的关联。这些研究可能涉及进行面对面的访谈并获得生物学样本（例如血液样本或脸颊拭子）来确定潜在的致癌作用的机制。这项拟议的研究将提供有关特征良好的队列人群中一系列暴露水平（PBB）的潜在致癌作用的信息。该调查中的信息可以应用于对具有类似结构的其他环境持续的细胞增生器的研究，这些结构具有公共卫生的关注，例如PCB，DDT/DDE和溴化阻燃剂（PBDES）。