Health Behaviors and Mortality in Prostate Cancer Survivors in the Multiethnic Cohort Study

多种族队列研究中前列腺癌幸存者的健康行为和死亡率

基本信息

批准号：
10512554
负责人：
Stacey Kenfield
金额：
$ 8.08万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-23 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10512554
关键词：
Address Adult African American American American Association of Cancer Research Animal Feed Asian Americans Asian Pacific American Baseline Surveys Behavior Black race Body Size Body Weight Body mass index California Cancer Survivor Centers for Disease Control and Prevention (U.S.)Cessation of life Chinese Clinical Coffee Cohort Studies Cox Proportional Hazards Models Data Diabetes Mellitus Diagnosis Diagnostic Diet Dietary Component Dietary Factors Dietary Fiber Edible Plants Enrollment Ensure Ethnic Origin Ethnic group Fabaceae Family Family Caregiver Food Frequencies Funding Health behavior Heart Diseases Hispanic Incidence Institutes Intake Intervention Japanese Knowledge Latino Latinx Latinx population Malignant neoplasm of prostate Measures Meat Mediating Medical Native Hawaiian Nonmetastatic Nuts Outcome Pacific Island Americans Participant Patients Persons Pharmaceutical Preparations Physical activity Physicians Plants Population Population Heterogeneity Processed Meats Progress Reports Prospective Studies Prostate Public Health Questionnaires Race Recommendation Recording of previous events Reporting Research Risk Risk Factors Self Administration Smoking Smoking History Surveys Tea United States Update Vascular Plant Vegetable Oils Vegetables Weight Work advanced disease anticancer research base cancer diagnosis cancer health disparity cancer risk cohort demographics dietary egg ethnic diversity follow-up fruits and vegetables healthy lifestyle high risk improved indexing interest men modifiable risk mortality mortality risk multi-ethnic population based primary outcome prostate cancer risk prostate cancer survivors racial and ethnic racial and ethnic disparities research study saturated fat secondary outcome tumor progression

项目摘要

PROJECT ABSTRACT: Large racial/ethnic disparities exist for prostate cancer (PC) incidence and mortality. Between 2001-2017, the 5-year relative survival for Black, Asian American/Pacific Islander, and Latinx groups was lower compared to non-Latinx White men. Progressing to advanced disease is a pivotal concern among patients with non- metastatic PC, their family, caregivers, and physicians. A major gap in current knowledge is the lack of research studies focused on post-diagnostic modifiable factors from racially/ethnically diverse populations. Preliminary data suggest that a Healthful Plant-based Diet Index may be associated with a ~60% lower risk of incident fatal PC among healthy men. In addition, our team recently developed a post-diagnostic Prostate Health Behavior Score (focused on physical activity, weight, and diet) with higher scores associated with a ~55% lower risk of PC-specific mortality among men with PC. Even so, 92% of participants in these two analyses identified as non-Latinx White; thus, the findings may not be generalizable to the racially/ethnically diverse populations of people living with PC. In this R03, we propose to examine whether a Healthful Plant- based Diet Index or composite Prostate Health Behavior Score is associated with survival among men with PC in the population-based Multiethnic Cohort Study (MEC). The MEC is a diverse cohort of over 215,000 adults living predominately in southern California and Hawai’i when enrolled between 1993-1996. For these analyses, we will use data from 2,652 men with PC who have measures of health behaviors before and after diagnosis; 19% identified as African American, 25% identified as non-Latino White, 23% identified as Latino, 28% identified as Asian American, and 5% identified as Native Hawaiian. A comprehensive self-administered questionnaire captured demographics, body size, medical and family histories, medication use, smoking history, and physical activity at enrollment; and a quantitative food frequency questionnaire (FFQ) was also administered. Follow-up surveys have been administered every 4-6 years. Data from the baseline survey will be used to adjust for pre-diagnosis health behaviors and body weight. Using these data, we aim to 1) examine whether the Healthful Plant-based Diet Index, a Prostate Health Behavior Score, and their components, measured after PC diagnosis, are associated with lower risk of all-cause and PC-specific mortality; and 2) explore whether associations between these modifiable risk factors and mortality vary across racial/ethnic groups and the degree to which health behaviors contribute to observed racial/ethnic disparities in PC mortality. This work will be completed in the largest prospective study of racially/ethnically diverse men with PC in the U.S., ensuring the generalizability of our results and directly informing clinical and public health recommendations. In addition, this proposal will strengthen the evidence on the impact of health behaviors on outcomes in cancer survivors and could help reduce racial/ethnic disparities in PC outcomes, and guide interventions to ultimately help people with PC lower their risk of cancer progression and death.

项目摘要： 2001 年至 2017 年间，前列腺癌 (PC) 的发病率和死亡率存在巨大的种族/民族差异。黑人、亚裔美国人/太平洋岛民和拉丁裔群体的 5 年相对生存率低于进展为晚期疾病是非拉丁裔白人患者的一个关键问题。转移性 PC、他们的家人、护理人员和医生目前知识的一个主要差距是缺乏相关知识。研究重点是不同种族/民族人群的诊断后可改变因素。初步数据表明，健康的植物性饮食指数可能与降低约 60% 的风险相关此外，我们的团队最近开发了一种诊断后前列腺癌。健康行为评分（重点关注体力活动、体重和饮食），得分越高，与健康行为相关患有 PC 的男性的 PC 特异性死亡率降低了大约 55%，即便如此，这两项研究的参与者中仍有 92% 的人患有 PC 相关死亡率。分析被确定为非拉丁裔白人；因此，研究结果可能无法推广到种族/民族在本 R03 中，我们建议检查健康的植物是否是 PC 患者。基于饮食指数或综合前列腺健康行为评分与前列腺癌男性的生存相关在基于人群的多种族队列研究 (MEC) 中，MEC 是一个由超过 215,000 名成年人组成的多元化队列。 1993 年至 1996 年间注册时主要居住在加利福尼亚州南部和夏威夷。我们将使用 2,652 名患有 PC 的男性的数据，他们对诊断前后的健康行为进行了测量； 19% 被认为是非裔美国人，25% 被认为是非拉丁裔白人，23% 被认为是拉丁裔，28% 被认定为亚裔美国人，5% 被认定为夏威夷原住民全面的自我管理。问卷涵盖了人口统计数据、体型、医疗和家族史、药物使用、吸烟情况入组时的病史和体力活动；以及定量食物频率问卷（FFQ）后续调查每 4-6 年进行一次。用于调整诊断前的健康行为和体重，我们的目标是 1) 检查。健康植物性饮食指数、前列腺健康行为评分及其组成部分， PC 诊断后进行测量，与较低的全因死亡率和 PC 特异性死亡率相关；2) 探讨这些可改变的风险因素与死亡率之间的关联是否因种族/民族而异群体以及健康行为对 PC 中观察到的种族/民族差异的影响程度这项工作将在针对患有 PC 的种族/族裔男性的最大前瞻性研究中完成。在美国，确保我们的结果的普遍性并直接告知临床和公共卫生此外，该提案将加强健康行为对健康影响的证据。癌症幸存者的结果，有助于减少 PC 结果的种族/民族差异，并指导最终帮助 PC 患者降低癌症进展和死亡风险的干预措施。