Novel technique to detect microcracks in the progression of Osteoporosis

检测骨质疏松症进展中微裂纹的新技术

• 批准号: 10557618
• 负责人: Nirmala Kandadai
• 金额: $ 16.28万
• 依托单位: BOISE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-06 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557618
• 关键词: 3D Print; Acids; Adolescent; Adult; Affect; Age; Ballistics; Beds; Biomechanics; Bone Injury; Bone remodeling; Bone structure; Cattle; Ceramics; Clinic; Clinical; Cumulative Trauma Disorders; Defect; Deterioration; Development; Disease; Elderly; Engineering; Foundations; Fracture; Gel; Goals; Health; Hip Fractures; Human; Image; Imaging Techniques; Injury; Laboratories; Lasers; Life; Location; Magnetic Resonance Imaging; Measurement; Measures; Mechanics; Minor; Modeling; Osteoporosis; Outcome; Outcome Study; Patients; Persons; Polyurethanes; Porosity; Preventive treatment; Probability; Radiation; Radiometry; Research Personnel; Resolution; Risk; Sampling; Science; Signal Transduction; System; Techniques; Testing; Thermal Conductivity; Tissues; Tooth structure; United States; Variant; Visible Radiation; Vision; Weight-Bearing state; Work; X-Ray Computed Tomography; bisphosphonate; bone; bone health; common treatment; cost; demineralization; diagnostic platform; healing; improved; in vivo; normal aging; novel; optical imaging; particle; tool; treatment planning

PROJECT SUMMARY -- KANDADAI Osteoporosis is a major problem with a high impact on human life, affecting over 48 million people in the United States. Normally, healthy bone constantly undergoes remodeling, which helps heal minor micro-fractures caused by day-to-day activity and keeps bones strong. Osteoporosis affects remodeling, increasing the probability of fracture. One of the common treatments for osteoporosis is bisphosphonates. However, while it has been shown to improve osteoporosis, long-term bisphosphonate treatment creates the risk of generating micro-cracks and increases the chance of hip fractures. Both the disease and treatment cause a change in the porosity of the bone, and currently, there are no viable techniques that accurately measure changes in the bone porosity. Currently, two techniques are used to study the deterioration of bone, magnetic resonance imaging (MRI) and computerized tomography (CT). Both techniques suffer from low resolution making micro-cracks in the bone difficult to detect. In addition, MRI and CT are not readily amenable to measuring the effects of day-to-day activity, load-bearing, and age on bone porosity, which would be needed to create a preventative treatment plan. In our proposed project we are investigating a novel visible-light imaging technique to study and differentiate a variety of bone porosity and micro-cracks. In our project, we will use a technique known as modulated photothermal radiometry (MPTR) that measures the porosity-dependent thermal conductivity of materials, such as bone. MPTR has two potential advantages over MRI and CT: 1) it uses visible light to study the deterioration of bone without harmful radiation, and 2) it is easier to implement in vivo with higher resolution. The work will have wide-reaching significance, both in the laboratory and in real life. Quantification of bone porosity and micro- cracks will improve the understanding of the effects of bone remodeling, a major issue in osteoporosis and other repetitive bone injuries.

项目摘要-Kandadai 骨质疏松症是一个主要问题，对人类的生活产生了很大影响，影响超过4800万 美国的人。通常，健康的骨骼不断进行重塑，这是 有助于治愈由日常活动引起的轻微微裂纹，并保持骨骼强烈。 骨质疏松症会影响重塑，从而增加骨折的可能性。普通之一 骨质疏松的治疗是双膦酸盐。但是，尽管已证明它可以改善 骨质疏松症，长期双膦酸盐治疗产生了产生微裂缝的风险 并增加了髋部骨折的机会。疾病和治疗都会改变 骨骼的孔隙率，目前没有可行的技术来准确测量 骨孔隙度的变化。目前，使用两种技术来研究 骨，磁共振成像（MRI）和计算机断层扫描（CT）。这两种技术 难以检测到的骨骼中的小裂缝低分辨率。此外，MRI 和CT不容易测量日常活动的影响，负载， 和骨孔隙率的年龄，这是制定预防性治疗计划所需的。在 我们提出的项目我们正在研究一种新型的可见光成像技术，以研究和 区分各种骨孔隙度和微裂缝。在我们的项目中，我们将使用一种技术 被称为调制光热辐射仪（MPTR） 材料的导热率，例如骨骼。 MPTR比MRI具有两个潜在的优势 和CT：1）它使用可见光研究骨骼的恶化而无需有害辐射，而2） 通过更高的分辨率在体内实施更容易。这项工作将有广泛的范围 在实验室和现实生活中的意义。骨孔隙度和微观的定量 裂缝将改善对骨骼重塑影响的理解，这是 骨质疏松症和其他重复的骨损伤。