CNS-Met Administrative Core

CNS-Met 行政核心

• 批准号: 10557543
• 负责人: Patrick G Sullivan
• 金额: $ 93.31万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-15 至 2028-02-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10557543
• 关键词: Advisory Committees; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Biology; Biomedical Research; Brain; Brain Injuries; Cardiovascular Diseases; Cardiovascular system; Centers of Research Excellence; Central Nervous System; Collaborations; Committee Members; Communication; Core Facility; Data Science; Dedications; Diabetes Mellitus; Disease; Ensure; Epilepsy; Evaluation; Faculty; Fostering; Funding; Glucose; Goals; Homeostasis; Human Resources; Infrastructure; Interdisciplinary Study; Investments; Kentucky; Laboratories; Leadership; Life; Malignant Neoplasms; Medicine; Mentors; Metabolism; National Institute of General Medical Sciences; Neurons; Neurosciences; Neurosciences Research; Obesity; Occupational activity of managing finances; Parkinson Disease; Physiology; Pilot Projects; Process; Regulation; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Role; Schedule; Scientist; Senior Scientist; Services; Specific qualifier value; Stroke; Structure; Synapses; System; Techniques; Training Programs; Traumatic brain injury related dementia; Traumatic injury; United States National Institutes of Health; Universities; brain metabolism; career; career development; collaborative environment; college; defined contribution; experience; faculty mentor; infrastructure development; innovation; instrumentation; interest; knowledge translation; meetings; metabolomics; metabolomics resource; mitochondrial metabolism; multidisciplinary; nervous system disorder; neural; neuroinflammation; neuropathology; neurotransmission; next generation; novel; operation; programs; recruit; senior faculty; skills; spinal cord and brain injury; stable isotope; synergism; tumor metabolism

PROJECT SUMMARY – ADMINISTRATIVE CORE Research in CNS metabolism has garnered interest from many fields, including Alzheimer’s Disease, brain injury (including traumatic injury, stroke, etc), epilepsy, and Parkinson’s Disease, and likely involves all areas of CNS-related research. The University of Kentucky College of Medicine has made significant investments over the last few years in both metabolomics instrumentation and investigators with metabolomics expertise that enhanced existing UK strengths in neuroscience, cancer, cardiovascular, and diabetes & obesity research. The objective of this application is to create an NIH Center of Biomedical Research Excellence (COBRE) in CNS Metabolism (CNS-Met). This proposal builds on existing strengths at UK as well as strengths of both the senior and junior investigators in brain physiology, neuropathology, and CNS metabolism. The CNS-Met Administrative Core (Admin Core) will coordinate communication and access among the CNS-Met groups, the above-mentioned metabolism-centric research programs, and other existing UK strengths as well as core facilities established by other UK COBREs to support a multidisciplinary, team-based program that trains the next generation of faculty focused on brain metabolism. The CNS-Met Administrative Core is directed by Dr. Matthew Gentry and co-directed by Dr. Patrick Sullivan, senior scientists with complementary expertise in CNS metabolism and demonstrated leadership skills. The Core will ensure and provide effective coordination and oversight of research projects, research cores usage and service, general infrastructure, administrative, and fiscal matters. It will provide robust and timely financial management and will facilitate internal communication between CNS-Met constituents. It will be responsible for coordinating the recruitment of future research project leaders and mentors and for managing and implementing pilot program funding. The Admin Core will do all of these activities while ensuring that CNS-Met activities are in compliance with federal regulations. The overarching goal of the CNS-Met Administrative Core is to deliver administrative, fiscal, and scientific leadership and center-wide coordination to COBRE Research Project Leaders, their mentors, research core, and other COBRE-supported investigators. To achieve these goals, the core will: 1) Coordinate operational and fiscal management, infrastructure and program planning, and communication processes across all COBRE components.; and 2) Facilitate and coordinate research training, mentoring, and career development activities for early-stage investigators in brain metabolism research; 3) Implement a pilot studies program to seed new research across neuroscience research thrusts; and 4) Provide effective formative and summative assessment of COBRE projects and activities of the CNS-Met group.

项目摘要 - 行政核心 CNS代谢的研究吸引了许多领域的兴趣，包括阿尔茨海默氏病，大脑 受伤（包括创伤性伤害，中风等），癫痫病和帕金森氏病，可能涉及 中枢神经系统有关的研究。肯塔基大学医学院已经对 最近几年的代谢组学仪器和具有代谢组学专业知识的研究人员 在神经科学，癌症，心血管和糖尿病和肥胖研究中增强了英国现有的优势。这 该应用的目的是在CNS中创建NIH生物医学研究卓越中心（Cobre） 代谢（CNS-MET）。该提案以英国现有优势以及高级的优势为基础 以及大脑生理学，神经病理学和中枢神经系统代谢的初级研究者。 CNS-MET 行政核心（管理员核心）将协调CNS-MET组之间的通信和访问 上述以代谢为中心的研究计划以及其他现有的英国优势以及核心 英国其他Cobres建立的设施，以支持一项基于多学科的，基于团队的计划，该计划培训 下一代教师专注于脑代谢。 CNS-MET行政核心由博士指导。 马修·绅士 代谢并展示领导能力。核心将确保并提供有效的协调和 监督研究项目，研究核心使用和服务，一般基础设施，行政和 财政问题。它将提供强大而及时的财务管理，并促进内部沟通 在CNS-MET之间构成。它将负责协调未来研究项目的招聘 领导者和导师以及管理和实施试点计划资金。管理员核心将完成所有 这些活动在确保CNS-MET活动符合联邦法规的同时。 CNS-MET行政核心的总体目标是提供行政，财政和科学 领导力和中央范围的协调，索布雷研究项目领导者，他们的导师，研究 核心和其他由毛线支持的研究人员。为了实现这些目标，核心将：1）协调 运营和财政管理，基础架构和计划计划以及沟通过程 在所有毛线组件中； 2）促进和协调研究培训，心理和职业 早期研究人员在大脑代谢研究中的开发活动； 3）实施试点研究 计划在神经科学研究中播种新的研究； 4）提供有效格式， 对CNS-MET组的山羊项目和活动的总结评估。