Integrated Physiology Training: Molecule to Organism

综合生理学培训：分子到有机体

• 批准号: 10553817
• 负责人: Matthew Robert Hodges
• 金额: $ 43.39万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10553817
• 关键词: Organism; Physiology; Training

Project Summary Scientific training in the Physiological sciences in the U.S. has undergone a transformation largely toward molecular mechanisms and away from whole animal integrative physiology, creating a shortage of scientists and educators with mastery of integrative physiology. The Physiology training program at the Medical College of Wisconsin (MCW) is an exception to this trend. Our training program offers multidisciplinary instruction and cutting-edge integrative physiology research training emphasizing the integration of knowledge from the molecule to cell to organ to organism. Trainees develop the critical thinking, integrative reasoning, and technical skills participating in research focused on the prevention and control of HLBS diseases such as hypertension, metabolic disease, epilepsy and chronic respiratory diseases. Our current proposal maintains a focus on critical thinking, organ systems physiology and translational research training with enhancements in: 1) interdisciplinary instruction, 2) self-directed learning, 3) the trainee candidate pool, 4) the acceleration of reaching training milestones, 5) instruction in rigor and reproducibility in the scientific method, and 6) the recruitment of students from populations underrepresented in science and medicine. Trainees are recruited nationally from geographically diverse areas and selected on a competitive basis on undergraduate academic credentials, previous research experience, and commitment to a career in research in the Physiological Sciences. Students are full-time PhD candidates, and must successfully complete the course and research requirements, including passing the Qualifying Exam before being considered for NIH training grant support. Selection of T32 trainees will be based on several performance metrics in coursework and research productivity, in addition to the alignment of their research focus in the Physiological sciences and the candidate’s potential for a successful career in the biomedical sciences. An innovative feature of the training program is to meet the anticipated need to train students in integrative physiology to meet the growing need for such expertise in the era of Team Science and in the post-genomic era. Research training is under the direct supervision of highly skilled and experiences faculty preceptors in the basic sciences (primarily Physiology) and enhanced by clinical faculty. Trainees will undergo continuous evaluation of progress by Individual Development Plans that facilitate career development and progress toward individualized trainee goals. The success of our program in training is evidenced by a high completion rate and publication record of the twelve T32 supported graduates in the past 10 years, who had 25 first-authored and 42 co-authored publications (~5.6/trainee). The high number of co-authored publications reflects the highly collaborative environment among our faculty and Team Science approach. Each of these trainees has gone on to academic research, teaching or patient care positions indicative of the success of our approach to ensuring the future of integrative physiology into the future. Based on the long-term success of our training program, we hereby request funds to support 8 predoctoral students in each of the next 5 years.

项目摘要 美国生理科学的科学培训在很大程度上经历了转变 分子机制，远离整个动物综合生理学，造成科学家和 掌握综合生理学的教育者。医学院的生理培训计划 威斯康星州（MCW）是这一趋势的例外。我们的培训计划提供多学科教学和 尖端的综合生理研究培训强调了知识的整合 分子到细胞到生物体。学员发展了批判性思维，综合推理和技术 参与研究的技能专注于预防和控制HLBS疾病，例如高血压， 代谢疾病，癫痫和慢性呼吸道疾病。我们当前的提议关注关键 思维，器官系统生理学和转化研究培训，并提高：1）跨学科 指导，2）自我指导的学习，3）学员候选人池，4）加速培训 里程碑，5）科学方法的严格和可重复性的说明，以及6）学生的招募 来自科学与医学的人群不足。学员是从全国招募的 地理不同的领域，并以竞争性在本科学术证书的基础上进行选择， 以前的研究经验以及对生理科学研究职业的承诺。学生 是全职博士候选人，必须成功完成课程和研究要求，包括 在考虑NIH培训赠款支持之前，通过合格考试。选择T32受训者 除了课程工作和研究生产力中的几个绩效指标 他们的研究重点放在生理科学和候选人成功的潜力上 生物医学的职业。培训计划的创新功能是满足预期的需求 培训学生进行综合生理学，以满足团队科学时代对这种专业知识的日益增长的需求 并在后期时代。研究培训是在高技能和经验的直接监督下 基础科学（主要是生理学）中的教职员工，并通过临床教师增强。学员会 通过促进职业发展的个人发展计划对进步进行持续评估 并朝着个性化的实习生目标迈进。我们的计划在培训方面的成功得到了高 过去10年中，十二个T32支持毕业生的完成率和出版记录，他们有25年 首先被撰写和42个合着的出版物（〜5.6/truinee）。共同作品的大量出版物 反映了我们教师和团队科学方法中高度协作的环境。每个 学员一直从事学术研究，教学或患者护理职位，以表明我们的成功 确保综合生理学对未来的未来的方法。基于我们的长期成功 培训计划，我们特此请求资金在接下来的5年中为8名学生提供支持。

项目成果

RNASeq-derived transcriptome comparisons reveal neuromodulatory deficiency in the CO2 insensitive brown Norway rat.

RNASeq 衍生的转录组比较揭示了对 CO2 不敏感的棕色挪威大鼠的神经调节缺陷。

• DOI: 10.1113/jphysiol.2014.285171
• 发表时间: 2014
• 期刊: The Journal of physiology
• 作者: Puissant,MadeleineM;Echert,AshleyE;Yang,Chun;MouradianJr,GaryC;Novotny,Tyler;Liu,Pengyuan;Liang,Mingyu;Hodges,MatthewR
• 通讯作者: Hodges,MatthewR

Pulmonary arterial dilation by inhaled NO: arterial diameter, NO concentration relationship.

吸入NO引起的肺动脉扩张：动脉直径、NO浓度关系。

• DOI: 10.1152/jappl.2001.91.5.1948
• 发表时间: 2001
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Bentley,J;Rickaby,D;Haworth,ST;Hanger,CC;Dawson,CA
• 通讯作者: Dawson,CA

Global identification and characterization of tRNA-derived RNA fragment landscapes across human cancers.

人类癌症中 tRNA 衍生的 RNA 片段景观的全球鉴定和表征

• DOI: 10.1093/narcan/zcaa031
• 发表时间: 2020-12
• 期刊: NAR cancer
• 影响因子: 5.1
• 作者: Sun X;Yang J;Yu M;Yao D;Zhou L;Li X;Qiu Q;Lin W;Lu B;Chen E;Wang P;Chen W;Tao S;Xu H;Williams A;Liu Y;Pan X;Cowley AW Jr;Lu W;Liang M;Liu P;Lu Y
• 通讯作者: Lu Y

Novel adaptive and innate immunity targets in hypertension.

• DOI: 10.1016/j.phrs.2017.03.015
• 发表时间: 2017-06
• 期刊: Pharmacological research
• 影响因子: 9.3
• 作者: Abais-Battad JM;Dasinger JH;Fehrenbach DJ;Mattson DL
• 通讯作者: Mattson DL

Tnni3k influences cardiomyocyte S-phase activity and proliferation.

• DOI: 10.1016/j.yjmcc.2023.08.004
• 发表时间: 2023-08
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Alexandra L Purdy;Samantha K Swift;H. Sucov;Michaela Patterson