Integrated Physiology Training: Molecule to Organism

综合生理学培训：分子到有机体

• 批准号: 10439685
• 负责人: Matthew Robert Hodges
• 金额: $ 18.43万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10439685
• 关键词: Organism; Physiology; Training

PROJECT SUMMARY Over the last twenty years, training in Physiology departments throughout the country has undergone a transformation that creates a challenge for students seeking an understanding of the discipline at the whole animal to the cellular and molecular levels. One exception is the Physiology Department of the Medical College of Wisconsin (MCW), that offers exceptional research training emphasizing the integration of knowledge at all of these levels, and the relationship of this knowledge to human disease processes. In our current proposal, we will continue providing this outstanding training in cellular, molecular, and whole animal Physiology for 6 NIH- supported trainees each year. In addition, we request funds to provide stipends for 6 rising 2nd year medical students enrolled at MCW to spend 11 weeks during the summer engaged in research in the laboratory of one of our faculty to enhance recruitment of medical students into biomedical research. Unique aspects of the proposed PhD training are the multidisciplinary mentoring program and opportunities for translational research fostered by a highly collaborative basic science and clinical faculty. Graduate students will be recruited nationally and selected for admission on the basis of undergraduate academic credentials, previous research experience, and commitment to a career in research. Students must successfully complete the requirements of the first two years of graduate school before being considered for T32 support. Selection of T32 trainees will be based on performance in course work, the preliminary examination and in research. Trainees are full-time Ph.D. candidates in the MCW Graduate School, and will complete a research that includes use of the techniques in molecular, cellular, tissue, and whole-animal or clinical investigation. Research training is supervised by Physiology faculty along with co-mentors from other basic science and clinical departments. Trainees will undergo continuous evaluation by utilizing Individual Development Plans created upon matriculation, which are reviewed and updated yearly. The major objective is to provide trainees with a broad foundation in interdisciplinary basic science and translational research through developing critical thinking, integrative reasoning, and technical skills required to succeed in evolving research careers focused on the prevention of hypertension, stroke, and respiratory diseases. An innovative feature of the training is the emphasis on addressing the national need to train for the integrated- systems approaches that represent the future of biomedical research in the post-genomic era. The success of our program in research is indicated by the 47 first-authored publications from 24 T32 supported graduates over the past 10 years (Table 5A), and their contribution to 51 manuscripts coauthored with other students or faculty, indicative of our highly collaborative training program. Another measure of overall success of our program is that 94% of T32 trainees who completed our program over the past 15 years (Table 8A) have continued in a biomedical field, with 18 obtaining research, teaching, and/or patient care faculty positions and only two trainees withdrew from the program without obtaining the PhD (average duration of training was 4.96 years).

项目摘要 在过去的二十年中，全国生理学部门的培训已经接受了 转型为寻求对整个动物的学科了解的学生带来了挑战 到细胞和分子水平。一个例外是医学院的生理系 威斯康星州（MCW），提供了卓越的研究培训，强调了所有知识的整合 这些水平以及这些知识与人类疾病过程的关系。在当前的建议中，我们将 继续提供在细胞，分子和整个动物生理学方面的出色培训，用于6 NIH- 每年支持学员。此外，我们要求资金为6年级的6年医疗提供津贴 在夏季，学生在MCW招收11周的学生在实验室进行研究 我们的教师将医学生招募到生物医学研究中。独特的方面 拟议的博士培训是多学科指导计划和翻译研究的机会 由高度协作的基础科学和临床教师培育。研究生将在全国范围内招募 并根据本科学术证书，以前的研究经验，被选为入学 并致力于研究职业。学生必须成功完成前两个的要求 在考虑T32支持之前，多年的研究生院。 T32学员的选择将基于 课程工作，初步检查和研究中的表现。学员是专职博士学位。候选人 在MCW研究生院，将完成一项研究，其中包括使用分子中的技术， 细胞，组织以及全动物或临床研究。研究培训由生理学教师监督 与其他基础科学和临床部门的联合官员一起。学员将经历连续 通过利用在入学时创建的个人发展计划来评估，并进行审查和更新 每年。主要目的是为受训者提供跨学科基础科学的广泛基础， 通过发展批判性思维，综合推理和技术技能的转化研究 成功地发展了专注于预防高血压，中风和呼吸系统疾病的研究职业。 培训的创新特征是强调解决综合培训的国家需求 - 系统方法代表了后代后时代生物医学研究的未来。成功的成功 我们的研究计划是由24个T32支持毕业生的47个成文作的出版物指示的 过去的10年（表5A），以及与其他学生或教职员工共同撰写的51个手稿的贡献， 指示我们高度协作的培训计划。我们计划的总体成功的另一个衡量标准是 在过去15年中完成我们计划的T32学员中，有94％（表8A）继续 生物医学领域，有18个获得研究，教学和/或患者护理教师职位，只有两个学员 从计划中撤出而没有获得博士学位（平均培训持续时间为4。96年）。