Administrative Core

行政核心

• 批准号: 10552987
• 负责人: David A Bernlohr
• 金额: $ 50.71万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-02 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10552987
• 关键词: Adherence; Adipose tissue; Adoption; Aging; Animals; Atlases; Bacterial Artificial Chromosomes; Basic Science; Biochemistry; Biology; Biology of Aging; Biophysics; Brain; Cell Aging; Cells; Cellular biology; Clinic; Collaborations; Common Data Element; Communication; Communities; Critical Care; Data; Data Analyses; Data Collection; Data Coordinating Center; Data Set; Development; Development Plans; Emerging Technologies; Ensure; Evaluation; Experimental Designs; Funding; Future; Gene Expression Profiling; Generations; Goals; Grant; Head; Histology; Home; Human; IACUC; Immunology; Institutes; Interdisciplinary Study; International; Knowledge; Laboratories; Leadership; Lipids; Liver; Lung; Management Information Systems; Metabolic; Methods; Midwestern United States; Minnesota; Molecular Biology; Mus; Muscle; Obesity; Osteoporosis; Paper; Pathology; Pharmacology; Phenotype; Pilot Projects; Procedures; Productivity; Protocols documentation; Readiness; Reporting; Reproducibility; Research; Research Personnel; Role; Sampling; Signal Transduction; Site; Software Tools; Technology; Testing; Time; Tissues; Training; Training Activity; Transfer Agreement; Transgenic Mice; United States National Institutes of Health; Universities; Validation; Visualization; Visualization software; Work; analytical tool; biomarker discovery; bone; career; cohesion; data exchange; data integration; data sharing; data standards; data submission; data visualization; experience; human tissue; innovation; medical schools; meetings; metadata standards; mouse model; nano-string; novel strategies; operation; oxidized lipid; programs; ranpirnase; senescence; single cell analysis; technology development; tissue mapping; tool; webinar

PROJECT SUMMARY The Administrative Core (AC) for the Midwest Murine-Tissue Mapping Center (MM-TMC) for Senescent Cells (SnCs) will be led by three PIs with synergistic expertise and extensive experience leading multidisciplinary research centers: Dr. David Bernlohr (UMN), an expert in adipose biology, lipid signaling, and more recently cellular senescence; Dr. Sundeep Khosla (Mayo), an expert in bone biology, cellular senescence, and mouse models to clear and report SnCs; and Dr. Scott Budinger (Northwestern), an expert in lung biology, single cell transcriptional profiling, and the biology of aging. The main goals of the AC are to facilitate interactions between the MM-TMC cores to maximize the TMC’s productivity, to create a seamless interface between the MM-TMC Data Analysis Core (DAC) and the SenNet Consortium Organization and Data Coordinating Center (CODCC), and to promote interactions with other human and mouse TMCs and UG3s (Technology Development Projects). The specific responsibilities of the AC are to i) coordinate and oversee the MM-TMC cores to facilitate access to murine tissues, data collection, analysis, and integration; ii) administer a pilot project program focused on developing innovative approaches to identify and characterize SnCs; iii) coordinate MM-TMC activities with those of other TMCs to enhance the rigor and reproducibility of mapping SnCs in mice and using mouse data to inform the human SnC mapping efforts.; iv) facilitate communication between the our DAC and the CODCC to ensure adherence to standard operating procedures (SOPs) and definitions of common data elements and to enable timely data submission; v) facilitate collaborations between the MM-TMC team and SenNet that will yield network-wide metrics for data generation and metadata standards, inter-TMC and TMC-UG3 collaborations and cross-training, and a cohesive plan for the development of data analysis and visualization tools for the broader scientific community. The Specific Aims of the MM-TMC AC are to: 1) Oversee and coordinate efforts of the MM-TMC to ensure that research goals and milestones are met with highest quality standards; 2) Integrate input from the MM-TMC DAC and the SenNet CODCC to develop and ensure compliance with SOPs for generating data sets that enable the development of a multi-dimensional atlas of SnCs with healthy mouse aging. 3) Oversee and coordinate the exploration and evaluation of novel approaches for detecting, deeply phenotyping, tracing, and perturbing SnCs as technologies emerge from pilot projects, UG3 projects, other TMCs, and external groups studying SnCs or building cell atlases; and 4) Coordinate the activities of MM-TMC with other TMCs to optimize research efficiency and economies of scale and scope, including contributing to the adoption and/or further development of data standards, analytic tools, data sharing/visualization/discovery tools, and multi-site studies and training. Successful execution of these aims will optimize the operations of MM-TMC, maximize our contribution to SenNet, and ensure compliance with SenNet SOPs that support rigor and reproducibility.

项目摘要 中西部鼠组织映射中心（MM-TMC）的行政核心（AC）用于衰老细胞 （SNC）将由三个PI领导，具有协同的专业知识和丰富的多学科经验 研究中心：David Bernlohr博士（UMN），脂肪生物学，脂质信号以及最近的专家 细胞感应； Sundeep Khosla博士（Mayo），骨生物学，细胞感应和小鼠专家 清除和报告SNC的模型；和Scott Budinger博士（西北），肺部生物学专家，单细胞 转录分析和衰老的生物学。 AC的主要目标是促进 MM-TMC核心以最大化TMC的生产率，以在MM-TMC之间创建无缝接口 数据分析核心（DAC）和Sennet联盟组织和数据协调中心（CODCC）， 并促进与其他人类和小鼠TMC和UG3（技术开发项目）的互动。 AC的具体责任是i）协调和监督MM-TMC核心以促进访问 用于鼠组织，数据收集，分析和整合； ii）管理着针对的试点项目计划 开发创新的方法来识别和表征SNC； iii）与这些活动协调MM-TMC活动 其他TMC可增强在小鼠中映射SNC的严格性和可重复性，并使用鼠标数据告知 人类SNC映射工作。 iv）促进我们的DAC和CODCC之间的沟通以确保 遵守标准操作程序（SOP）和通用数据元素的定义，并启用 及时数据提交； v）促进MM-TMC团队与Sennet之间的合作 用于数据生成和元数据标准，TMC和TMC-ug3协作的网络范围范围指标以及 交叉训练，以及开发数据分析和可视化工具的凝聚力计划，以更广泛 科学界。 MM-TMC AC的具体目的是：1）监督和协调的努力 MM-TMC确保符合最高质量标准的研究目标和里程碑； 2）集成输入 从MM-TMC DAC和Sennet CodCC来开发并确保符合SOP的生成 可以开发具有健康小鼠衰老的SNC的多维地图集的数据集。 3）监督 并协调对检测，深层表型，追踪，探索和评估的探索和评估 并将SNC扰动为试点项目，UG3项目，其他TMC和外部小组的技术 研究SNC或建筑细胞地图集； 4）协调MM-TMC与其他TMC的活动以优化 研究效率和规模和范围的经济，包括为采用和/或进一步的贡献 开发数据标准，分析工具，数据共享/可视化/发现工具以及多站点研究 和培训。这些目标的成功执行将优化MM-TMC的操作，最大 对Sennet的贡献，并确保遵守支持严格和可重复性的Sennet SOP。