Molecular and Cellular Basis of Obesity Core

肥胖核心的分子和细胞基础

基本信息

批准号：
8132707
负责人：
David A Bernlohr
金额：
$ 28.28万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2016-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8132707
关键词：
Address Adipocytes Adipose tissue Affect Animal Model Animals Award Biochemistry Biology Biophysics Cell Line Cells Collaborations Communities Development Diabetes Mellitus Doctor of Philosophy Energy Metabolism Fatty Acids Fostering Future Gene Expression Gene Proteins Genes Genome Genomics Head Human Indirect Calorimetry Individual Inflammation Insulin Journals Knock-out Lentivirus Vector Link Lipids Liver Mentors Metabolic Metabolism Methodology MicroRNAs Minnesota Mitochondria Molecular Molecular Biology Obesity Obesity associated disease Oxidative Stress Pancreas Peripheral Phenotype Physical activity Physiology Process Production Proteins Proteome Proteomics Reporting Research Research Personnel Research Project Grants Role Sampling Science Services Signal Transduction Skeletal Muscle Structure of nucleus infundibularis hypothalami Study Section Systems Biology Technology Time Transgenic Organisms United States National Institutes of Health Universities Viral Vector Work base body system career editorial experience fatty acid-binding proteins gain of function interest macrophage meetings member metabolomics professor protein metabolite translational study working group

项目摘要

The Molecular and Cellular Basis for Obesity Core is a broadly based research and technology center that emphasizes the genes, proteins and metabolites linked to obesity and obesity-related disease. Dr. David Bernlohr, PhD, is the Core Director. Dr. Bernlohr is Professor and Head of the Department of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota. He is the recipient of a Distinguished McKnight University Professorship and holds the Cargill Chair in Systems Biology of Human Metabolism. Dr. Bernlohr has served the scientific community in a number of capacities. He has served on the editorial boards for the Journal of Biological Chemistry, Protein Science and the Journal of Lipid Research. He finished his second term as a permanent member ofthe Integrated Physiology of Obesity and Diabetes (IPOD) Study Section and was (ihair of IPOD from 2008-2009. Dr. Bernlohr holds multiple NIH awards and has studied adipose biology his entire professional career. His primary research themes involve the role of fatty acid binding proteins and fatty acid transporters in adipocyte and macrophage metabolism, oxidative stress and mitochondrial metabolism and the role of inflammation in obesity. He uses a combination of genomic, proteomic and metabolomic methodologies in his studies and uses a variety of cell based and animal models (knockout and transgenic) in his work. He is ideally suited to be Core Director for his experimental expertise utilizes all the Core technologies and he is able to address questions plus serve as a mentor for others interested in basic obesity research. Dr. Bernlohr will devote 5% of his effort to directing the Core and will be responsible for: ¿ Overseeing all budgetary and scientific activities of the Core ¿ Representing the Core on the Center Executive Committee ¿ Preparing all Core reports and providing information on Core activities to the Center Director ¿ Evaluating Core usage and needs and planning for future development ¿ Organizing the Core Research Club ¿ Assisting in the oversight of the Gene Expression and Analysis Subcore, especially with regard to development and use of lentiviral vectors. The Core will be organized into three primary subcores with each one having a subcore leader:

肥胖核心的分子和细胞基础是一个基于广泛的研究和技术中心，该中心强调与肥胖和与肥胖相关疾病相关的基因，蛋白质和代谢产物。 David Bernlohr博士博士是核心主任。 Bernlohr博士是明尼苏达大学生物化学，分子生物学与生物物理学系教授兼负责人。他是杰出的麦克奈特大学教授职位的接受者，并担任嘉吉人类代谢系统生物学的主席。博士伯恩洛（Bernlohr）曾在许多能力上为科学界服务。他曾在生物化学，蛋白质科学和脂质研究杂志的编辑委员会任职。他在肥胖和糖尿病综合生理学（iPod）研究部分的第二任期结束了他的第二任期（2008- 2009年iPod的IHAIR）。Bernlohr博士持有多个NIH奖，并研究了脂肪生物学的整个职业职业。他的主要研究涉及脂肪酸的作用。结合蛋白质和脂肪酸转运蛋白在脂肪细胞和巨噬细胞代谢，氧化物应激和线粒体代谢以及炎症在肥胖症中的作用。他在研究中使用了基因组，蛋白质组学和代谢组方法的结合，并在他的工作中使用了各种基于细胞和动物模型（基因敲除和转基因）。他非常适合成为实验专家的核心主任，利用所有核心技术，他能够解决问题，也可以作为他人的心理对基本肥胖研究感兴趣。 Bernlohr博士将致力于指导核心的5％的努力，并将负责： »监督核心的所有预算和科学活动 �代表中心执行委员会的核心 »准备所有核心报告并向中心主任提供有关核心活动的信息 »评估核心用法和需求以及计划未来发展 �组织核心研究俱乐部 »协助监督基因表达和分析子核，尤其是在慢病毒载体的发展和使用方面。核心将分为三个主要子核，每个子核有一个子核心领导者：