Cerebellar Interactions with the Amygdala and Prefrontal Cortex during Learning

学习过程中小脑与杏仁核和前额皮质的相互作用

基本信息

批准号：
10550256
负责人：
John H Freeman
金额：
$ 37.45万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-01 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10550256
关键词：
Affect Alzheimer&apos s Disease Amygdaloid structure Anatomy Animals Area Association Learning Attention Behavioral Blinking Cerebellum Cognition Cognitive Communication Conditioned Stimulus Data Electrophysiology (science)Elements Emotional Emotions Environment Etiology Event Extinction Feedback Funding Goals Image Learning Life Medial Mediating Memory Memory impairment Methods Motor Nature Organism Output Pathway interactions Performance Physiological Play Pontine structure Prefrontal Cortex Process Prosencephalon Rattus Research Role Safety Short-Term Memory Signal Transduction Site Stimulus Stroke Structure System Testing Training conditioned fear granule cell indexing learned behavior machine learning algorithm motor control motor learning nervous system disorder neural neural circuit neuromechanism novel optogenetics programs response two-photon

项目摘要

Learning is how organisms adapt to changes in their environment and involves the coordination of neural systems mediating cognition, emotion, and motor control. The major goal of the proposed research program is to elucidate the neural circuit mechanisms underlying interactions between cognitive, emotional, and motor systems during associative learning. Interactions between these neural systems are particularly important because the context and emotional significance of stimuli provide essential information for acquisition and performance of motor responses. The breakdown of interactions between cognitive, emotional, and motor systems in various neurological disorders can therefore have devastating consequences for learned behaviors. The prefrontal cortex, amygdala, and cerebellum play significant roles in cognition, emotional responses, and motor learning, respectively. The proposed research program constitutes a comprehensive analysis of cerebellar interactions with the amygdala and prefrontal cortex during associative motor learning. Our general conceptual framework is that the cerebellum receives inputs from the amygdala and prefrontal cortex via the pons regarding which stimuli are important and when they occur, and the cerebellum then sends error-driven feedback to these forebrain systems to facilitate learning about important events. This conceptual framework takes into account the bidirectional relationship between the cerebellum and the relevant forebrain systems as well as interactions between forebrain systems. Multi-site electrophysiology, pathway-specific optogenetics, and precise behavioral analyses will be combined to investigate circuit-level interactions between the cerebellum, amygdala, and prefrontal cortex during associative learning and extinction (inhibitory learning) training. The proposed studies would significantly advance understanding of the neural circuit mechanisms underlying cerebellar interactions with the forebrain. This would be a substantial contribution to the field because it has been known that the cerebellum must interact with the forebrain in many contexts that are crucial for everyday life such as learning, memory, planning, control of emotions, and communication, but very little is known mechanistically about how the cerebellum interacts with the amygdala and prefrontal cortex.

学习是生物如何适应其环境变化并涉及协调介导认知，情感和运动控制的神经系统。主要目标拟议的研究计划是阐明相互作用的神经回路机制在关联学习过程中的认知，情感和运动系统之间。互动在这些神经系统之间尤其重要，因为背景和情感刺激的意义为电动机的获取和性能提供了必不可少的信息回答。认知，情感和运动系统之间相互作用的分解因此，各种神经系统疾病可能会对学到的造成毁灭性的后果行为。前额叶皮层，杏仁核和小脑在认知中起着重要作用，情绪反应和运动学习。拟议的研究计划构成了与杏仁核和前额叶的小脑相互作用的全面分析关联运动期间的皮层。我们一般的概念框架是小脑通过pons从杏仁核和前额叶皮层接收输入哪些刺激很重要，何时发生，小脑然后发送错误驱动对这些前脑系统的反馈，以促进学习重要事件。这概念框架考虑了小脑之间的双向关系以及相关的前脑系统以及前脑系统之间的相互作用。多站点电生理学，途径特异性光遗传学和精确的行为分析将是合并研究小脑，杏仁核和联想学习和灭绝（抑制性学习）培训期间的前额叶皮层。这拟议的研究将显着提高对神经回路机制的理解小脑与前脑的相互作用。这将是对该领域是因为已经知道小脑必须与前脑相互作用对于日常生活至关重要的环境，例如学习，记忆，计划，控制情绪和沟通，但很少有关于小脑的机理知名度与杏仁核和前额叶皮层相互作用。