Cerebellar Interactions with the Amygdala and Prefrontal Cortex during Learning

学习过程中小脑与杏仁核和前额皮质的相互作用

• 批准号: 10550256
• 负责人: John H Freeman
• 金额: $ 37.45万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10550256
• 关键词: Affect; Alzheimer' s Disease; Amygdaloid structure; Anatomy; Animals; Area; Association Learning; Attention; Behavioral; Blinking; Cerebellum; Cognition; Cognitive; Communication; Conditioned Stimulus; Data; Electrophysiology (science); Elements; Emotional; Emotions; Environment; Etiology; Event; Extinction; Feedback; Funding; Goals; Image; Learning; Life; Medial; Mediating; Memory; Memory impairment; Methods; Motor; Nature; Organism; Output; Pathway interactions; Performance; Physiological; Play; Pontine structure; Prefrontal Cortex; Process; Prosencephalon; Rattus; Research; Role; Safety; Short-Term Memory; Signal Transduction; Site; Stimulus; Stroke; Structure; System; Testing; Training; conditioned fear; granule cell; indexing; learned behavior; machine learning algorithm; motor control; motor learning; nervous system disorder; neural; neural circuit; neuromechanism; novel; optogenetics; programs; response; two-photon

Learning is how organisms adapt to changes in their environment and involves the coordination of neural systems mediating cognition, emotion, and motor control. The major goal of the proposed research program is to elucidate the neural circuit mechanisms underlying interactions between cognitive, emotional, and motor systems during associative learning. Interactions between these neural systems are particularly important because the context and emotional significance of stimuli provide essential information for acquisition and performance of motor responses. The breakdown of interactions between cognitive, emotional, and motor systems in various neurological disorders can therefore have devastating consequences for learned behaviors. The prefrontal cortex, amygdala, and cerebellum play significant roles in cognition, emotional responses, and motor learning, respectively. The proposed research program constitutes a comprehensive analysis of cerebellar interactions with the amygdala and prefrontal cortex during associative motor learning. Our general conceptual framework is that the cerebellum receives inputs from the amygdala and prefrontal cortex via the pons regarding which stimuli are important and when they occur, and the cerebellum then sends error-driven feedback to these forebrain systems to facilitate learning about important events. This conceptual framework takes into account the bidirectional relationship between the cerebellum and the relevant forebrain systems as well as interactions between forebrain systems. Multi-site electrophysiology, pathway-specific optogenetics, and precise behavioral analyses will be combined to investigate circuit-level interactions between the cerebellum, amygdala, and prefrontal cortex during associative learning and extinction (inhibitory learning) training. The proposed studies would significantly advance understanding of the neural circuit mechanisms underlying cerebellar interactions with the forebrain. This would be a substantial contribution to the field because it has been known that the cerebellum must interact with the forebrain in many contexts that are crucial for everyday life such as learning, memory, planning, control of emotions, and communication, but very little is known mechanistically about how the cerebellum interacts with the amygdala and prefrontal cortex.

学习是生物体如何适应环境的变化并涉及协调 介导认知、情感和运动控制的神经系统。该计划的主要目标是 拟议的研究计划是阐明相互作用背后的神经回路机制 联想学习期间认知、情感和运动系统之间的关系。互动 这些神经系统之间的关系尤其重要，因为背景和情感 刺激的重要性为运动的获取和表现提供重要信息 回应。认知、情感和运动系统之间相互作用的崩溃 因此，各种神经系统疾病可能会对学习能力产生毁灭性的后果 行为。前额皮质、杏仁核和小脑在认知、 分别是情绪反应和运动学习。拟议的研究计划 构成小脑与杏仁核和前额叶相互作用的综合分析 联想运动学习期间的皮层。我们的总体概念框架是 小脑通过脑桥接收来自杏仁核和前额皮质的输入 哪些刺激很重要以及何时发生，然后小脑发送错误驱动的信号 向这些前脑系统提供反馈，以促进了解重要事件。这 概念框架考虑了小脑之间的双向关系 和相关的前脑系统以及前脑系统之间的相互作用。多站点 电生理学、通路特异性光遗传学和精确的行为分析将 结合起来研究小脑、杏仁核和大脑之间的电路级相互作用 联想学习和消退（抑制学习）训练期间的前额叶皮层。这 拟议的研究将显着促进对神经回路机制的理解 小脑与前脑的潜在相互作用。这将是一个重大贡献 这个领域是因为众所周知，小脑必须与前脑在许多方面相互作用 对日常生活至关重要的环境，例如学习、记忆、计划、控制 情绪和交流，但人们对小脑如何机制知之甚少 与杏仁核和前额皮质相互作用。