Activity-Dependent Mechanisms of Memory Consolidation

记忆巩固的活动依赖性机制

• 批准号: 10534735
• 负责人: MARK S GOLDMAN
• 金额: $ 58.95万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10534735
• 关键词: Amygdaloid structure; Area; Automobile Driving; Behavior; Behavioral; Brain; Brain region; Cell Nucleus; Cerebellum; Cognition; Computer Models; Data; Dissection; Episodic memory; Eye Movements; Foundations; Goals; Hippocampus; Individual; Learning; Measures; Mediating; Memory; Modeling; Motor Skills; Movement; Nature; Neurons; Output; Process; Research; Sensory; Shapes; Short-Term Memory; Site; Societies; Synapses; System; Testing; Time; Training; Vision; Work; candidate identification; conditioned fear; density; experience; experimental study; improved; in vivo; insight; long term memory; medial vestibular nucleus; memory acquisition; memory consolidation; motor learning; neural; neural circuit; neural patterning; neurotransmission; oculomotor; optogenetics; predictive modeling; transmission process; visual information

PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning adjusts the neural circuitry controlling eye movements, to maintain the accuracy of eye movements over short and long time scales. The specific focus of the research is to understand how oculomotor learning, i.e., improvement of the accuracy of eye movements through experience, is transferred from short-term to long-term storage. This consolidation process occurs, not only for motor skills like eye movements, but is a general feature of learning and memory systems. Some memories, including oculomotor memories, are transformed during the time after the initial acquisition of the memory, in a way that renders older, consolidated memories independent of brain areas that are critical for newer memories. This process, known as systems consolidation, is thought to depend on activity of neurons in the brain area initially critical for the memory, and the hypothesis is that this activity induces changes in the brain area(s) supporting long-term storage of the memory. The proposed research characterizes the nature of the neural signals transmitted between brain areas supporting memory at different times after their acquisition, and the rules that operate on those neural signals to implement stable transfer of a memory from one brain area to another.

项目摘要 视觉是一种积极的感觉，眼睛的动作有力地塑造了视觉的获取 有关世界的信息。该项目调查运动学习如何调整神经 控制眼动的电路，以维持短片的眼睛运动的准确性 长时间尺度。该研究的具体重点是了解动眼运动如何 即，通过经验提高了眼睛运动的准确性，从 短期到长期存储。这种整合过程不仅是针对运动技能 眼动，但是学习和记忆系统的一般特征。一些回忆， 包括动眼记忆在内，在最初获取后的时间发生了转换 记忆，以较旧的，合并的记忆的方式，与大脑区域无关 对于新的回忆至关重要。这个过程称为系统合并，被认为取决于 关于最初对记忆至关重要的神经元活动的活动，假设是 该活动会导致大脑区域的变化，以支持记忆的长期存储。 拟议的研究表征了大脑之间传播的神经信号的性质 在收购后的不同时间支持记忆的领域，以及运行的规则 那些神经信号将记忆从一个大脑区域稳定转移到另一个大脑。