Activity-Dependent Mechanisms of Memory Consolidation

记忆巩固的活动依赖性机制

• 批准号: 10319168
• 负责人: MARK S GOLDMAN
• 金额: $ 57.18万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10319168
• 关键词: Amygdaloid structure; Area; Automobile Driving; Behavior; Behavioral; Brain; Brain region; Cell Nucleus; Cerebellum; Cognition; Computer Models; Data; Dissection; Episodic memory; Eye Movements; Foundations; Goals; Hippocampus (Brain); Individual; Learning; Measures; Mediating; Memory; Modeling; Motor Skills; Movement; Nature; Neurons; Output; Process; Research; Sensory; Shapes; Short-Term Memory; Site; Societies; Synapses; System; Testing; Time; Training; Vision; Work; base; conditioned fear; density; experience; experimental study; in vivo; insight; long term memory; medial vestibular nucleus; memory acquisition; memory consolidation; motor learning; neural circuit; neural patterning; neurotransmission; oculomotor; optogenetics; predictive modeling; relating to nervous system; visual information

PROJECT SUMMARY Vision is an active sense, with eye movements powerfully shaping the acquisition of visual information about the world. This project investigates how motor learning adjusts the neural circuitry controlling eye movements, to maintain the accuracy of eye movements over short and long time scales. The specific focus of the research is to understand how oculomotor learning, i.e., improvement of the accuracy of eye movements through experience, is transferred from short-term to long-term storage. This consolidation process occurs, not only for motor skills like eye movements, but is a general feature of learning and memory systems. Some memories, including oculomotor memories, are transformed during the time after the initial acquisition of the memory, in a way that renders older, consolidated memories independent of brain areas that are critical for newer memories. This process, known as systems consolidation, is thought to depend on activity of neurons in the brain area initially critical for the memory, and the hypothesis is that this activity induces changes in the brain area(s) supporting long-term storage of the memory. The proposed research characterizes the nature of the neural signals transmitted between brain areas supporting memory at different times after their acquisition, and the rules that operate on those neural signals to implement stable transfer of a memory from one brain area to another.

项目概要 视觉是一种主动的感觉，眼球运动有力地塑造了视觉的获取 有关世界的信息。该项目研究运动学习如何调整神经 控制眼球运动的电路，以在短时间内保持眼球运动的准确性 长时间尺度。该研究的具体重点是了解动眼神经学习是如何进行的， 即，通过经验提高眼球运动的准确性，是从 短期至长期储存。这种巩固过程不仅适用于运动技能，例如 眼球运动，而是学习和记忆系统的一般特征。一些回忆， 包括动眼记忆在内，在最初获得记忆后的时间内发生了转变 记忆，以一种使较旧的、巩固的记忆独立于大脑区域的方式 对于新的记忆至关重要。这个过程被称为系统整合，被认为取决于 最初对记忆至关重要的大脑区域神经元的活动，假设是 这种活动会引起支持长期记忆存储的大脑区域发生变化。 拟议的研究描述了大脑之间传输的神经信号的性质 获取后不同时间支持记忆的区域，以及操作的规则 这些神经信号实现记忆从一个大脑区域到另一个大脑区域的稳定转移。