Regional Prospective Observational Research in Tuberculosis (RePORT) – Brazil Network

结核病区域前瞻性观察研究 (报告) – 巴西网络

• 批准号: 10535081
• 负责人: BRUNO DE BEZERRIL ANDRADE
• 金额: $ 100万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-02 至 2027-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10535081
• 关键词: Acquired Immunodeficiency Syndrome; Area; Biological Assay; Biological Markers; Blood; Brazil; C-reactive protein; Caribbean region; Categories; Cellular Phone; Central America; Characteristics; China; Clinical; Clinical Data; Collaborations; Collection; Country; DNA; Data; Data Coordinating Center; Databases; Dedications; Demographic Factors; Diabetes Mellitus; Diagnosis; Diagnostic tests; Disease; Disease Notification; Drug resistance in tuberculosis; Drug resistant Mycobacteria Tuberculosis; Enrollment; Epidemiology; Ethambutol; Fellowship; Fluoroquinolones; Fostering; Foundations; Funding; Future; Genomics; Global Positioning System; Grant; Growth; HIV; HIV/TB; Hemoglobin; Immunology; Incidence; Incubators; India; Individual; Indonesia; Infection; Interferon Type II; International; Intervention; Molecular Epidemiology; Morbidity - disease rate; Mycobacterium tuberculosis; Observation in research; Outcome; Participant; Pathogenesis; Patients; Peripheral Blood Mononuclear Cell; Persons; Pharmaceutical Preparations; Pharmacogenomics; Phase; Philippines; Pilot Projects; Plasma; Population; Postdoctoral Fellow; Prediabetes syndrome; Predisposition; Prevention; Publications; Pulmonary Tuberculosis; Pyrazinamide; RNA; Registries; Research; Research Personnel; Resource-limited setting; Rifampicin resistance; Rifampin; Risk; Risk Factors; Role; Science; Scientific Advances and Accomplishments; Scientist; Sentinel; Site; South Africa; South America; Specimen; Sputum; Statistical Methods; System; Treatment outcome; Tuberculosis; Tuberculosis diagnosis; United States; Urine; Validation; Weight Gain; Whole Blood; Work; World Health Organization; biobank; career development; cohort; design; experience; fluoroquinolone resistance; follow-up; improved; inflammatory marker; insight; isoniazid; mortality; neutrophil; next generation; novel; novel diagnostics; outcome prediction; participant enrollment; point of care; predictive modeling; progression risk; prospective; transcriptomics; transmission process; tuberculosis diagnostics; tuberculosis treatment

PROJECT SUMMARY Brazil has the highest tuberculosis (TB) burden in the Western Hemisphere, and among the highest in the world. Advances in TB diagnosis, treatment, and prevention are necessary to improve the incidence, morbidity, and mortality of TB in Brazil, and globally. Regional Prospective Observational Research in TB (RePORT)- Brazil was initiated by our group in 2013, and enrolled 1,188 pulmonary TB patients and 1,930 of their close contacts in Phase 1. Clinical data and stored biorepository specimens have facilitated studies of predictors of TB and TB/HIV treatment outcomes, predictors of M. tuberculosis (Mtb) infection and progression to TB disease and incipient TB, TB-diabetes, drug-resistant TB, TB diagnostics, and Mtb transmission. Strong collaborations have been established with investigators in Brazil and the United States, as well as other RePORT networks (e.g., South Africa and India), the Caribbean Central America South America network for HIV epidemiology (CCASAnet) and its TB Sentinel Research Network (TB-SRN), which is part of the International epidemiologic Databases to Evaluate AIDS (IeDEA) network. In Phase 2 of RePORT-Brazil we will utilize the rich, high-quality clinical, genomic, and transcriptomic data generated in Phase 1, together with new participant enrollment, to extend our understanding of TB epidemiology and pathogenesis, and improve the diagnosis, treatment, and prevention of TB. This will be accomplished through three Specific Aims: 1) Gain insights that improve TB diagnosis, treatment, and outcomes. This will include external validation utilizing the TB case registry in Brazil (SINAN; the Brazilian National System of Diseases Notification), and other Brazilian registries as appropriate; 2) Improve our understanding of Mtb transmission and infection, including latent, incipient, and sub-clinical disease; predictors of progression to TB, and protection against TB; and 3) Support and develop the next generation of TB scientists, and enhance the scope and collaboration of RePORT-Brazil. For Aim 3, we will fund Fellowships in TB Science, focusing on Brazilian investigators. This will include two Early Career Development Fellowships per year, for pilot projects that support Brazil-US partnerships, and generate preliminary data for subsequent grant funding; and two Post-Doctoral Fellowships per year. Both categories of support will be for studies that utilize RePORT-Brazil data and/or specimens; proposals that also include data and specimens from other TB cohorts will be encouraged. The three Aims will facilitate further growth and strengthening of RePORT-Brazil, and generate insights that improve the diagnosis, treatment, and prevention of TB in Brazil.

项目摘要 巴西在西半球的结核病（TB）负担最高，并且是最高的 世界。结核病诊断，治疗和预防的进展是提高发病率，发病率， 在巴西和全球的结核病死亡率。结核病（报告）中的区域前瞻性观察研究 - 巴西由我们的小组于2013年发起，招募了1,188例肺结核患者和1,930名关闭 第1阶段的接触。 结核病和TB/HIV治疗结果，结核分枝杆菌（MTB）感染的预测因子和进展为TB 疾病和起步性结核病，结核病糖尿病，耐药结核病，结核病诊断和MTB传播。强的 已经与巴西和美国的调查人员以及其他合作建立了合作 报告网络（例如南非和印度），加勒比中美洲南美网络 HIV流行病学（CCASANET）及其TB Sentinel研究网络（TB-SRN），它是该网络的一部分 评估AIDS网络的国际流行病学数据库。在报告 - 巴西的第二阶段我们 将利用在第1阶段生成的丰富，高质量的临床，基因组和转录组数据 新的参与者入学，以扩展我们对结核病流行病学和发病机理的理解，并改善 结核病的诊断，治疗和预防。这将通过三个具体目标来完成：1） 改善结核病诊断，治疗和结果的见解。这将包括利用外部验证 巴西的结核病案例注册（西南；巴西国家疾病通知）和其他巴西人 适当的注册； 2）提高我们对MTB传播和感染的理解，包括潜在， 初期和临床疾病；预测向结核病的进展和防止结核病的预测因素； 3）支持 并发展下一代结核病科学家，并增强报告巴西的范围和协作。 对于AIM 3，我们将资助结核病科学奖学金，重点关注巴西调查员。这将包括两个 每年的早期职业发展奖学金，用于支持巴西 - 美国合作伙伴关系的试点项目， 生成初步数据以进行后续赠款资金；以及每年两项博士后研究金。两个都 支持类别将用于利用报告 - 巴西数据和/或标本的研究；提案也是如此 包括数据和来自其他结核病队列的标本。这三个目标将进一步 报告巴西的增长和加强，并产生洞察力，以改善诊断，治疗和 预防巴西结核病。