Administrative Core

行政核心

• 批准号: 10517258
• 负责人: Collin m Blakely
• 金额: $ 2.79万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10517258
• 关键词: Advocate; American Association of Cancer Research; American Society of Clinical Oncology; Animal Experimentation; Basic Science; Biology; Budgets; Cancer Advocacy; Chemicals; Clinical; Clinical Research; Collaborations; Communication; Communities; Data; Data Science Core; Disputes; Doctor of Philosophy; Ensure; Epidermal Growth Factor Receptor; Evaluation; Event; Evolution; Feedback; Funding; Generations; Goals; IACUC; Institutes; Institutional Review Boards; Interpersonal Relations; KRAS2 gene; Knowledge; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of lung; Modeling; Molecular; Organoids; Patient advocacy; Patients; Progress Reports; Reporting; Research; Research Personnel; Resistance; Resource Sharing; Role; Signal Transduction; Teleconferences; Therapeutic; TimeLine; Translational Research; Travel; Update; Work; Xenograft procedure; data management; data sharing; human subject; meetings; molecular targeted therapies; patient advocacy group; programs; single cell analysis; symposium; targeted treatment; therapy resistant; tumor; tumor microenvironment

Project Summary/Abstract: The main goal of the BAATAAR-UP ARTNet Admin Core is to ensure regular communication between the leaders and teams involved in Project 1 led by Dr. Bivona and Dr. Blakely (Clinical tumor-TME acquired resistance), Project 2 led by Dr. Roth and Dr. Bivona (PDX tumor-TME acquired resistance), Project 3 led by Dr. Bandyopadhyay and Dr. Kuo (PDO tumor- TME acquired resistance), and the Data Science Core, led by Dr. Wang and Dr. Bandyopadhyay. Additional goals include ensuring regular communication with the NCI, and other ARTNet centers as well as with the basic, translational, and clinical scientific stakeholders, and with lung cancer advocacy groups and the public at large. These goals will be accomplished through three specific aims. The first aim will be to effectively manage and integrate scientific projects and budgets. The Admin Core will create a Leadership Team consisting of the Project and Data Science Core Leads, which will evaluate the progress and impact of research accomplished through regular monthly team meetings as well as an annual retreat. The Admin Core will also oversee the submission of scientific progress reports to the NCI in collaboration with the Leadership Team. The second aim of the Admin Core will be to organize intra and trans-institutional activities to ensure regular communication between the project teams with each other and with the Data Sciences Core. The Admin Core will ensure resource and data sharing between each Project and with the Data Science Core. The Admin Core will also ensure regular communication between the Leadership Team and the Scientific Advisory Board (SAB), as well as the broader scientific and patients advocacy community. This will be accomplished by organizing an annual research retreat in which project teams will present research progress and receive feedback and guidance from the SAB. The SAB will include a range of experts with extensive knowledge of EGFR and KRAS biology and acquired resistance to molecular targeted therapies as well as clinical and patient expertise. The Admin Core will also ensure regular presentation of our findings by coordinating travel and presentations at scientific conferences. Finally, the Admin Core will ensure engagement with patient advocacy groups and the general lay community. In these events, our scientific team will communicate our research to a diverse lay audience, as well as seek input and observations from the community for our work. The third aim of the Admin Core is to organize interactions with the NCI and other national ARTNet Centers. The Admin Core will spearhead coordination and communication directly with the ARTNet Coordinating and Data Management Center (CDMC) and NCI scientific staff, as well as coordinate teleconferences with other ARTNet centers and/or the NCI scientific staff to communicate updates on the progress of the Research Program and enhance the strength of interpersonal interactions among all ARTNet stakeholders.

项目摘要/摘要：Baataar-Up Artnet管理员核心的主要目标是确保常规 由Bivona博士和Blakely博士领导的项目1的领导者与参与项目1的团队之间的沟通（临床 肿瘤-TME获得了抵抗），由Roth博士和Bivona博士领导的项目2（PDX肿瘤-TME获得了 阻力），由Bandyopadhyay博士和Kuo博士领导的项目3（PDO肿瘤获得了抵抗），以及 数据科学核心，由Wang博士和Bandyopadhyay博士领导。其他目标包括确保常规 与NCI和其他Artnet中心以及基本，翻译和临床的沟通 科学利益相关者，以及肺癌倡导团体和整个公众。这些目标将是 通过三个特定目标完成。第一个目的是有效管理和整合科学 项目和预算。管理员核心将创建一个由项目和数据组成的领导团队 科学核心领导将评估通过常规的研究的进步和影响 每月团队会议以及年度务虚会。管理员核心还将监督提交 科学进步与领导团队合作向NCI报告。管理员的第二个目标 核心将是组织内部和跨机构活动，以确保 相互项目团队以及数据科学核心。管理员核心将确保资源和 每个项目与数据科学核心之间的数据共享。管理员核心还将确保常规 领导团队与科学顾问委员会（SAB）之间的沟通以及更广泛的 科学和患者倡导社区。这将通过组织年度研究来实现 撤退项目团队将提出研究进度，并从中获得反馈和指导 sab。 SAB将包括一系列对EGFR和KRAS生物学知识的专家 获得了对分子靶向疗法以及临床和患者专业知识的耐药性。管理员核心 还将通过协调科学的旅行和演示来确保我们的发现定期呈现 会议。最后，管理员核心将确保与患者的倡导团体和一般性参与 外行社区。在这些事件中，我们的科学团队将向不同的外行受众传达我们的研究， 以及从社区寻求我们的工作的意见和观察。管理员核心的第三个目标是 组织与NCI和其他国家Artnet中心的互动。管理员核心将带头头 直接与ARTNET协调和数据管理中心进行协调和沟通 （CDMC）和NCI科学人员，以及与其他Artnet中心和/或 NCI科学人员传达有关研究计划进展的最新信息，并增强 所有ARTNET利益相关者之间人际交往的力量。