Administrative Core

行政核心

• 批准号: 10705113
• 负责人: Collin m Blakely
• 金额: $ 18.73万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-30 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705113
• 关键词: Advocate; American Association of Cancer Research; American Society of Clinical Oncology; Animal Experimentation; Area; Basic Science; Biology; Budgets; Cancer Advocacy; Chemicals; Clinical; Clinical Research; Collaborations; Communication; Communities; Data; Data Coordinating Center; Data Science Core; Disputes; Doctor of Philosophy; Ensure; Epidermal Growth Factor Receptor; Evaluation; Event; Evolution; Feedback; Funding; Generations; Goals; IACUC; Institution; Institutional Review Boards; Interpersonal Relations; KRAS2 gene; Knowledge; Lead; Leadership; Malignant Neoplasms; Malignant neoplasm of lung; Modeling; Molecular; Organoids; Patient advocacy; Patients; Progress Reports; Reporting; Research; Research Personnel; Resistance; Resource Sharing; Role; Signal Transduction; Teleconferences; Therapeutic; Translational Research; Travel; Update; Work; Xenograft procedure; data sharing; human subject; meetings; molecular targeted therapies; patient advocacy group; programs; single cell analysis; symposium; targeted treatment; therapy resistant; timeline; tumor; tumor microenvironment

Project Summary/Abstract: The main goal of the BAATAAR-UP ARTNet Admin Core is to ensure regular communication between the leaders and teams involved in Project 1 led by Dr. Bivona and Dr. Blakely (Clinical tumor-TME acquired resistance), Project 2 led by Dr. Roth and Dr. Bivona (PDX tumor-TME acquired resistance), Project 3 led by Dr. Bandyopadhyay and Dr. Kuo (PDO tumor- TME acquired resistance), and the Data Science Core, led by Dr. Wang and Dr. Bandyopadhyay. Additional goals include ensuring regular communication with the NCI, and other ARTNet centers as well as with the basic, translational, and clinical scientific stakeholders, and with lung cancer advocacy groups and the public at large. These goals will be accomplished through three specific aims. The first aim will be to effectively manage and integrate scientific projects and budgets. The Admin Core will create a Leadership Team consisting of the Project and Data Science Core Leads, which will evaluate the progress and impact of research accomplished through regular monthly team meetings as well as an annual retreat. The Admin Core will also oversee the submission of scientific progress reports to the NCI in collaboration with the Leadership Team. The second aim of the Admin Core will be to organize intra and trans-institutional activities to ensure regular communication between the project teams with each other and with the Data Sciences Core. The Admin Core will ensure resource and data sharing between each Project and with the Data Science Core. The Admin Core will also ensure regular communication between the Leadership Team and the Scientific Advisory Board (SAB), as well as the broader scientific and patients advocacy community. This will be accomplished by organizing an annual research retreat in which project teams will present research progress and receive feedback and guidance from the SAB. The SAB will include a range of experts with extensive knowledge of EGFR and KRAS biology and acquired resistance to molecular targeted therapies as well as clinical and patient expertise. The Admin Core will also ensure regular presentation of our findings by coordinating travel and presentations at scientific conferences. Finally, the Admin Core will ensure engagement with patient advocacy groups and the general lay community. In these events, our scientific team will communicate our research to a diverse lay audience, as well as seek input and observations from the community for our work. The third aim of the Admin Core is to organize interactions with the NCI and other national ARTNet Centers. The Admin Core will spearhead coordination and communication directly with the ARTNet Coordinating and Data Management Center (CDMC) and NCI scientific staff, as well as coordinate teleconferences with other ARTNet centers and/or the NCI scientific staff to communicate updates on the progress of the Research Program and enhance the strength of interpersonal interactions among all ARTNet stakeholders.

项目摘要/摘要：BAATAAR-UP ARTNet 管理核心的主要目标是确保定期 Bivona 博士和 Blakely 博士领导的项目 1 的领导者和团队之间的沟通（临床 肿瘤-TME 获得性耐药性），由 Roth 博士和 Bivona 博士领导的项目 2（PDX 肿瘤-TME 获得性耐药性） 耐药性），由 Bandyopadhyay 博士和 Kuo 博士领导的项目 3（PDO 肿瘤 - TME 获得性耐药性），以及 数据科学核心，由 Wang 博士和 Bandyopadhyay 博士领导。其他目标包括确保定期 与 NCI 和其他 ARTNet 中心以及基础、转化和临床中心的沟通 科学利益相关者以及肺癌倡导团体和广大公众。这些目标将是 通过三个具体目标来实现。第一个目标是有效管理和整合科学 项目和预算。管理核心将创建一个由项目和数据组成的领导团队 科学核心领导，将通过定期评估所完成的研究的进展和影响 每月一次的团队会议以及年度静修会。管理核心还将监督提交 与领导团队合作向 NCI 报告科学进展。管理员的第二个目标 核心是组织内部和跨机构的活动，以确保各机构之间的定期沟通。 项目团队之间以及数据科学核心。管理核心将确保资源和 每个项目之间以及与数据科学核心之间的数据共享。管理核心还将确保定期 领导团队和科学顾问委员会 (SAB) 以及更广泛的人员之间的沟通 科学和患者倡导社区。这将通过组织年度研究来完成 务虚会上，项目团队将介绍研究进展并接受来自 SAB。 SAB 将包括一系列具有 EGFR 和 KRAS 生物学丰富知识的专家， 获得了对分子靶向治疗以及临床和患者专业知识的耐药性。管理核心 还将通过协调旅行和在科学会议上的演讲来确保定期介绍我们的发现 会议。最后，管理核心将确保患者权益团体和广大公众的参与 俗人社区。在这些活动中，我们的科学团队将向不同的非专业观众传达我们的研究成果， 并寻求社区对我们工作的意见和意见。管理核心的第三个目标是 组织与 NCI 和其他国家 ARTNet 中心的互动。管理核心将带头 直接与 ARTNet 协调和数据管理中心进行协调和沟通 (CDMC) 和 NCI 科学人员，以及协调与其他 ARTNet 中心和/或 NCI 科学人员交流研究计划的最新进展并加强 所有 ARTNet 利益相关者之间人际互动的强度。