Coordinating Center for the Program on the Origins of Gastroesophageal Cancers

胃食管癌起源项目协调中心

基本信息

批准号：
10506036
负责人：
JEANINE M. GENKINGER
金额：
$ 86.4万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-06 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10506036
关键词：
Area Award Bioinformatics Biometry Cancer Research Network Cells Classification Clinical Collaborations Communication Data Data Commons Data Element Development Ensure Evaluation FAIR principles Feedback Future Genome Genomics Goals Infrastructure Knowledge Leadership Malignant Neoplasms Malignant neoplasm of gastrointestinal tract Medical center Mentorship Metadata Methodology Mission Modeling Molecular Monitor Morbidity - disease rate New York Pathology Productivity Reproducibility Research Research Personnel Research Project Grants Resolution Resource Sharing Resources Risk Scientist Secure Standardization Structure Technology Time Training Training Programs Training Support Universities Vision Work clinical database cloud based collaborative approach data harmonization data portal data sharing experience gastroesophageal cancer in vitro Model in vivo meetings mortality multidisciplinary next generation organizational structure prevent programs success symposium synergism tumor web-accessible working group

项目摘要

The Columbia Coordinating Center (CCC) will provide the necessary leadership, infrastructure, and oversight to support and fulfill the overarching goals of NCI’s Program on the Origins of Gastroesophageal Cancers (PGEC) and the six transdisciplinary R01 projects. The mission of the PGEC is to extend recent findings regarding molecular classifications and genomics of gastroesophageal cancers, examine and define how these cancers initially evolve at the cellular level, and compare and contrast the contributions and underlying mechanisms of tumor-initiating cells to risk and progression. Inadequate coordination, communication and access will create significant barriers to program success. The CCC will provide the leadership and organizational structure to facilitate and strengthen cross collaboration through trainings, meetings and working groups. The CCC will develop standardization and harmonization of data elements (e.g., track the cell of origin correctly) across research projects, enable the resolution of technical challenges, share models and resources, and advance the use of cutting-edge technologies. The CCC will facilitate equitable and FAIR (employing principles of findability, accessibility, interoperability, and reusability) access to in vivo and in vitro models, provide real time feedback on research objectives and allow for assessment of rigor and reproducibly. The CCC will provide training and support for early-stage investigators to conduct pilot work and engage in transdisciplinary research to build the next generation of scientists. Our CCC and the assembled Scientific Advisory Board brings together multidisciplinary scientists with necessary and diverse research, clinical, database and consortia experience to support these aims. This research team in conjunction with the many institutional resources at Columbia University Irving Medical Center (CUIMC) and New York Genome Center (NYGC) will be pivotal assets to program success. Specific Aim 1: Provide strong vision and scientific leadership to ensure the PGEC meets its programmatic goals. Sub-Aim 1A- training and development of junior investigators; and Sub-Aim 1B- monitoring research progress and to provide real time feedback that are actionable. Specific Aim 2: Provide administrative oversight and structure for the PGEC. Specific Aim 3: Coordinate and organize meetings and conferences. Specific Aim 4: Build and maintain a data commons and portal for the program. Impact: The CCC will provide strong leadership with an experienced and multidisciplinary team and an organizational structure for all PGEC activities to facilitate resource sharing that will expedite productivity, collaboration, and ultimately impact to better understand and prevent GE cancer morbidity and mortality. Further integration with other long-standing resources and training programs are additional important deliverables.

哥伦比亚协调中心 (CCC) 将提供必要的领导、基础设施和监督支持并实现 NCI 胃食管癌起源计划 (PGEC) 的总体目标以及六个跨学科 R01 项目，PGEC 的使命是扩展有关的最新发现。胃食管癌的分子分类和基因组学，检查并定义这些癌症如何发生最初在细胞水平上进化，并比较和对比其贡献和潜在机制肿瘤起始细胞的协调、沟通和接触不足将导致风险和进展。计划成功的重大障碍。 CCC 将提供领导和组织结构，以促进和加强交叉合作通过培训、会议和工作组，CCC 将制定标准化和协调性。跨研究项目的数据元素（例如，正确跟踪起源细胞），能够解决技术问题 CCC 将应对挑战、共享模型和资源并推进尖端技术的使用。促进公平和公平（采用可查找性、可访问性、互操作性和可重用性原则）访问体内和体外模型，提供有关研究目标的实时反馈并进行评估 CCC 将为早期研究人员进行试点提供培训和支持。工作并从事跨学科研究以培养下一代科学家。我们的 CCC 和科学顾问委员会汇集了多学科科学家，并提供必要的支持以及多样化的研究、临床、数据库和联盟经验来支持这些目标。结合哥伦比亚大学欧文医学中心 (CUIMC) 的众多机构资源以及纽约基因组中心 (NYGC) 将成为项目成功的关键资产。具体目标 1：提供强有力的愿景和科学领导力，确保 PGEC 满足其目标计划目标 1A- 初级研究人员的培训和发展；和 1B- 监控研究进展并提供可行的实时反馈。具体目标 2：为 PGEC 提供行政监督和结构。具体目标 3：协调和组织会议。具体目标 4：为该计划构建和维护数据共享和门户。影响：CCC 将提供强有力的领导、经验丰富的多学科团队和所有 PGEC 活动的组织结构，以促进资源共享，从而提高生产力，合作，并最终影响更好地了解和预防 GE 癌症的发病率和死亡率。与其他长期资源和培训计划的整合是额外重要的交付成果。