Dietary Factors and Risk of Pancreatic Cancer in a Pooled Analysis

汇总分析中的饮食因素和胰腺癌风险

基本信息

批准号：
7862588
负责人：
JEANINE M. GENKINGER
金额：
$ 7.73万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-15 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7862588
关键词：
Alcohol consumption All-Trans-Retinol Animals Apoptosis Attenuated Blood flow Calcium Cell division Cheese Chemopreventive Agent Coffee Cohort Studies Complement Consumption Country Dairy Products Data Data Set Developing Countries Development Diet Dietary Factors Edible Plants Environment Epidemiologic Studies Epidemiology Etiology Evaluation Fatty acid glycerol esters Fiber Food Guidelines Hormonal Hormones Ice Cream In Vitro Incidence Individual Insulin Insulin-Like Growth Factor I Intake International Literature Malignant Neoplasms Malignant neoplasm of pancreas Meat Milk Modeling Nutrient Obesity Outcome Overweight Pathway interactions Pattern Physical activity Prevention Prospective Studies Research Risk Risk Factors Smoking Status Somatomedins Tea Time Vitamin D Yogurt angiogenesis cancer risk cancer site carcinogenesis cohort cost design diet and cancer follow-up insight non-smoker prospective soft drink sugar sweetened beverage tumor

项目摘要

DESCRIPTION (provided by applicant): Insulin and insulin like growth factor (IGF-1), and Vitamin D, have been hypothesized to be associated with risk of pancreatic cancer. High levels of insulin and IGF-1 may stimulate cell division, promote tumor development and increase local blood flow, while high levels of Vitamin D may reduce proliferation, angiogenesis and invasiveness, and increase differentiation and apoptosis. Dietary factors, such as sugar-sweetened beverages and dairy products, may modify the levels of these hormones and thus, ultimately impact cancer risk. Few studies, particularly those using a prospective design, have examined the association between these dietary factors (e.g. soft drinks, dairy products, vitamin D) and pancreatic cancer risk; results have been heterogeneous. In this application, we will examine associations between dietary factors related to insulin and IGF-1 (e.g., sugar sweetened beverages) and vitamin D (dairy products, vitamin D, calcium) and pancreatic cancer risk. We will further examine whether obesity, physical activity, and smoking status modify the association between these dietary factors and pancreatic cancer risk. These aims will be conducted within 14 studies in the Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project), an international consortium of cohort studies. The Pooling Project allows for prospective evaluation of dietary factors with rarer cancers, such as pancreatic cancer, by combining data from multiple studies. Also, the Pooling Project creates an environment where the definitions and modeling of the cohorts' exposures, covariates and outcomes are standardized, particularly important when discrepancies that are present in the literature may be due to different reference groups, cutoffs, exposure or outcome definitions across studies. The pancreatic cancer dataset for the Pooling Project has already been established; these cohorts provided dietary data from 869,694 individuals among whom 2,187 pancreatic cancer cases were identified during follow-up. Currently, we have data on over 40 nutrients, the foods on each FFQ, and over 40 potential cancer risk factors. Thus, the Pooling Project will provide an opportunity to examine in detail the associations between these dietary factors and pancreatic cancer risk with a large number of cases. Using this existing dataset in the Pooling Project to examine these aims will greatly expand on the dearth of literature and prospective data available on these associations using a cost- and time-efficient approach. Thus, this analysis may provide insight into the etiology of pancreatic cancer and ultimately aid in prevention of this highly fatal cancer.

描述（由申请人提供）：胰岛素和胰岛素类似生长因子（IGF-1）和维生素D已被认为与胰腺癌的风险有关。高水平的胰岛素和IGF-1可以刺激细胞分裂，促进肿瘤的发展并增加局部血液，而高水平的维生素D可能会降低增殖，血管生成和侵入性，并增加分化和凋亡。饮食因素（例如糖粉饮料和乳制品）可能会改变这些激素的水平，因此最终会影响癌症的风险。很少有研究，特别是使用前瞻性设计的研究，研究了这些饮食因素（例如软饮料，乳制品，维生素D）和胰腺癌风险之间的关联；结果是异质的。在此应用中，我们将研究与胰岛素和IGF-1（例如糖甜饮料）和维生素D（乳制品，维生素D，钙）和胰腺癌风险之间的饮食因素之间的关联。我们将进一步研究肥胖，体育锻炼和吸烟状况是否会改变这些饮食因素与胰腺癌风险之间的关联。这些目的将在14项研究的14项研究中进行，饮食和癌症的前瞻性研究（POMING项目），这是一个国际队列研究联盟。合并项目可以通过结合来自多个研究的数据，可以通过稀有癌症（例如胰腺癌）对饮食因素进行前瞻性评估。此外，汇总项目创造了一个环境，在该环境中，同类群体的定义和建模是标准化的，当文献中存在的差异可能是由于不同研究中的不同参考组，临界值，暴露或结果定义，尤其重要。池塘项目的胰腺癌数据集已经建立；这些队列提供了来自869,694个人的饮食数据，其中有2,187例胰腺癌病例在随访期间确定。目前，我们拥有40多种营养素，每种FFQ上的食物以及40多个潜在的癌症危险因素的数据。因此，集合项目将提供一个机会，详细检查这些饮食因素与胰腺癌风险与大量病例之间的关联。在池项目中使用此现有数据集检查这些目标将大大扩展有关使用成本和时间效率的方法在这些关联上获得的文献缺乏和预期数据。因此，该分析可能会洞悉胰腺癌的病因，并最终有助于预防这种高度致命的癌症。