Dietary Factors and Risk of Pancreatic Cancer in a Pooled Analysis

汇总分析中的饮食因素和胰腺癌风险

基本信息

批准号：
7862588
负责人：
JEANINE M. GENKINGER
金额：
$ 7.73万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-06-15 至 2012-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7862588
关键词：
Alcohol consumption All-Trans-Retinol Animals Apoptosis Attenuated Blood flow Calcium Cell division Cheese Chemopreventive Agent Coffee Cohort Studies Complement Consumption Country Dairy Products Data Data Set Developing Countries Development Diet Dietary Factors Edible Plants Environment Epidemiologic Studies Epidemiology Etiology Evaluation Fatty acid glycerol esters Fiber Food Guidelines Hormonal Hormones Ice Cream In Vitro Incidence Individual Insulin Insulin-Like Growth Factor I Intake International Literature Malignant Neoplasms Malignant neoplasm of pancreas Meat Milk Modeling Nutrient Obesity Outcome Overweight Pathway interactions Pattern Physical activity Prevention Prospective Studies Research Risk Risk Factors Smoking Status Somatomedins Tea Time Vitamin D Yogurt angiogenesis cancer risk cancer site carcinogenesis cohort cost design diet and cancer follow-up insight non-smoker prospective soft drink sugar sweetened beverage tumor

项目摘要

DESCRIPTION (provided by applicant): Insulin and insulin like growth factor (IGF-1), and Vitamin D, have been hypothesized to be associated with risk of pancreatic cancer. High levels of insulin and IGF-1 may stimulate cell division, promote tumor development and increase local blood flow, while high levels of Vitamin D may reduce proliferation, angiogenesis and invasiveness, and increase differentiation and apoptosis. Dietary factors, such as sugar-sweetened beverages and dairy products, may modify the levels of these hormones and thus, ultimately impact cancer risk. Few studies, particularly those using a prospective design, have examined the association between these dietary factors (e.g. soft drinks, dairy products, vitamin D) and pancreatic cancer risk; results have been heterogeneous. In this application, we will examine associations between dietary factors related to insulin and IGF-1 (e.g., sugar sweetened beverages) and vitamin D (dairy products, vitamin D, calcium) and pancreatic cancer risk. We will further examine whether obesity, physical activity, and smoking status modify the association between these dietary factors and pancreatic cancer risk. These aims will be conducted within 14 studies in the Pooling Project of Prospective Studies of Diet and Cancer (Pooling Project), an international consortium of cohort studies. The Pooling Project allows for prospective evaluation of dietary factors with rarer cancers, such as pancreatic cancer, by combining data from multiple studies. Also, the Pooling Project creates an environment where the definitions and modeling of the cohorts' exposures, covariates and outcomes are standardized, particularly important when discrepancies that are present in the literature may be due to different reference groups, cutoffs, exposure or outcome definitions across studies. The pancreatic cancer dataset for the Pooling Project has already been established; these cohorts provided dietary data from 869,694 individuals among whom 2,187 pancreatic cancer cases were identified during follow-up. Currently, we have data on over 40 nutrients, the foods on each FFQ, and over 40 potential cancer risk factors. Thus, the Pooling Project will provide an opportunity to examine in detail the associations between these dietary factors and pancreatic cancer risk with a large number of cases. Using this existing dataset in the Pooling Project to examine these aims will greatly expand on the dearth of literature and prospective data available on these associations using a cost- and time-efficient approach. Thus, this analysis may provide insight into the etiology of pancreatic cancer and ultimately aid in prevention of this highly fatal cancer.

描述（由申请人提供）：已假设胰岛素和胰岛素样生长因子 (IGF-1) 以及维生素 D 与胰腺癌风险相关。高水平的胰岛素和IGF-1可能会刺激细胞分裂，促进肿瘤发展并增加局部血流量，而高水平的维生素D可能会减少增殖、血管生成和侵袭性，并增加分化和凋亡。饮食因素，例如含糖饮料和乳制品，可能会改变这些激素的水平，从而最终影响癌症风险。很少有研究，特别是那些采用前瞻性设计的研究，探讨这些饮食因素（例如软饮料、乳制品、维生素 D）与胰腺癌风险之间的关联；结果参差不齐。在此应用中，我们将研究与胰岛素和 IGF-1（例如含糖饮料）和维生素 D（乳制品、维生素 D、钙）相关的饮食因素与胰腺癌风险之间的关联。我们将进一步研究肥胖、体力活动和吸烟状况是否改变这些饮食因素与胰腺癌风险之间的关联。这些目标将在饮食与癌症前瞻性研究汇集项目（汇集项目）的 14 项研究中实现，该项目是一个国际队列研究联盟。汇集项目可以通过结合多项研究的数据，对胰腺癌等罕见癌症的饮食因素进行前瞻性评估。此外，汇集项目创建了一个环境，使队列暴露、协变量和结果的定义和建模标准化，当文献中存在的差异可能是由于不同的参考组、截止值、暴露或结果定义而导致时，这一点尤其重要。研究。汇集项目的胰腺癌数据集已经建立；这些队列提供了 869,694 名个人的饮食数据，其中 2,187 名胰腺癌病例在随访期间被发现。目前，我们拥有 40 多种营养素、每个 FFQ 上的食物以及 40 多种潜在癌症风险因素的数据。因此，汇集项目将提供一个机会，通过大量病例详细检查这些饮食因素与胰腺癌风险之间的关联。使用池项目中的现有数据集来检查这些目标，将极大地利用成本和时间高效的方法来弥补这些协会可用的文献和前瞻性数据的缺乏。因此，该分析可以深入了解胰腺癌的病因学，并最终有助于预防这种高度致命的癌症。