1/2 CSUF/UCI-CFCCC Cancer Health Disparities Research Program (CHERP)

1/2 CSUF/UCI-CFCCC 癌症健康差异研究计划 (CHERP)

基本信息

批准号：
10492739
负责人：
MARCELO E TOLMASKY
金额：
$ 21.14万
依托单位：
CALIFORNIA STATE UNIVERSITY FULLERTON
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-22 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10492739
关键词：
Address Administrator Advisory Committees Advocate African American Applications Grants Asian Basic Science Biological Sciences Biotechnology Breast Cancer Risk Factor California Cancer Center Cancer Research Project Collaborations Communities Comprehensive Cancer Center County DNA sequencing Data Development Education Education and Outreach Educational Curriculum Environment Epidemiology Ethnic group Evaluation Faculty Family Fostering Funding Future Genetic Genomics Goals Grant Health Disparities Research Institution Institutionalization Joints Knowledge Length Lesbian Gay Bisexual Transgender Queer Low income Malignant Neoplasms Malignant neoplasm of ovary Oranges Pattern Pilot Projects Population Preparation Principal Investigator Recommendation Records Research Research Personnel Research Project Grants Research Training Sampling Scientist Seasons Students System Talents Teacher Professional Development Training Training Activity Training Programs Training and Education Underrepresented Students Underserved Population United States National Institutes of Health Universities anticancer research base cancer health disparity cancer research center director community based participatory research community engagement disability education research epidemiology study ethnic diversity experience graduate student health equity innovation institutional capacity lipidomics meetings member minority health disparity mortality outreach professor programs student training transcriptome sequencing transcriptomics triple-negative invasive breast carcinoma tumor undergraduate student underrepresented minority student

项目摘要

CSUF/UCI-CFCCC Cancer Health Equity Research Partnership (CHERP) Overall Component: Abstract California State University, Fullerton (CSUF) is an institution serving underserved populations and underrepresented students (ISUPS), and the University of California, Irvine Chao Family Comprehensive Cancer Center (UCI-CFCCC) is an NCI-designated comprehensive cancer center. Together, we plan to establish a collaborative partnership to develop pilot research projects between faculty members at CSUF and UCI-CFCCC that will generate preliminary data for R01 or other competitively funded grant applications, and educate undergraduates (at CSUF) and master's students (at CSUF and UCI) in cancer health disparities research. The Partnership plans to fund five pilot projects, and educate a total of 38 students during the length of the proposed grant period. The overall specific aims of this new cancer-specific partnership are to: plan, implement and evaluate a highly integrated and interactive cancer health disparities partnership between CSUF and UCI- CFCCC; conduct pilot cancer health disparities research projects involving at least one investigator at each institution that advance knowledge regarding cancer health disparities, leading to the submission of competitive grant applications by NIH/NCI and other federal/non-federal agencies; and provide cancer research education to underrepresented undergraduate and graduate students to increase their understanding of cancer health disparities, leading to a larger pool of highly talented future scientists from diverse backgrounds. To accomplish this we will undertake a set of activities organized under four components. The Administrative Core will be responsible for the overall administrative and fiscal aspects of all P20 activities, and will include the Executive Committee and Internal Advisory Committee. Activities will be implemented in three stages: initial planning, implementation, and evaluation. The evaluation effort will be spearheaded by an external evaluator with expertise in multi-component center reviews. The two pilot research projects each focus on a cancer health disparity: the first is a basic science study that will conduct lipidomic profiling, and DNA and RNA sequencing of tumor/NAT paired samples to optimize sample preparation and detect genetic/genomic and transcriptomic differences that are related to African American triple negative breast cancer risk. The second is an epidemiological study that will examine Asian sub-ethnic group differences in ovarian cancer mortality and treatment patterns. The long term goals of this collaborative partnership are to diversity the cancer research workforce and ultimately increase our scientific impact to address the cancer health disparity needs in Orange County, California.

CSUF/UCI-CFCCC癌症健康公平研究伙伴关系（CHERP）总体组件：摘要加利福尼亚州立大学，富勒顿（CSUF）是一家为服务不足的人口提供服务的机构代表性不足的学生（ISUPS）和加利福尼亚大学尔湾县综合癌症中心（UCI-CFCCC）是NCI指定的综合癌症中心。我们共同计划建立一个协作合作伙伴关系，以开发CSUF和UCI-CFCCC的教职员工之间的试点研究项目这将为R01或其他有竞争力的赠款申请生成初步数据，并教育癌症健康差异研究中的本科生（在CSUF）和硕士学生（在CSUF和UCI）。这合作伙伴计划为五个试点项目提供资金，并在拟议期间教育38名学生赠款期。这种新的特定癌症伙伴关系的总体具体目标是：计划，实施和评估CSUF与UCI之间的高度集成和互动性癌症健康差异的伙伴关系 CFCCC;进行试点癌症健康差异研究项目，涉及至少一名研究者促进有关癌症健康差异的知识的机构，导致提交竞争性 NIH/NCI和其他联邦/非联邦机构的赠款申请；并提供癌症研究教育代表人数不足的本科生和研究生来提高他们对癌症健康的理解差异，导致来自不同背景的高度才华横溢的未来科学家。为了实现这一目标，我们将开展一组在四个组成部分下组织的活动。行政核心将负责所有P20活动的整体行政和财政方面，并将包括执行委员会和内部咨询委员会。活动将分为三个阶段：初始计划，实施和评估。评估工作将由外部评估员带头具有多组分中心评论方面的专业知识。两个飞行员研究项目都集中在癌症健康上差异：第一个是一项基础科学研究，将进行脂质组分析，以及DNA和RNA测序肿瘤/NAT配对样品以优化样品制备并检测遗传/基因组和转录组与非裔美国人三重阴性乳腺癌风险有关的差异。第二个是流行病学研究将检查卵巢癌死亡率和治疗模式。这种合作伙伴关系的长期目标是多样性癌症研究劳动力并最终增加了我们的科学影响，以满足橙色的癌症健康差异需求加利福尼亚县。