Contribution of Sleep Disruption to Memory Impairment and Emotion Dysregulation in Fetal Alcohol Spectrum Disorders

睡眠中断对胎儿酒精谱系障碍中记忆障碍和情绪失调的影响

• 批准号: 10491056
• 负责人: SANDRA W. JACOBSON
• 金额: $ 12.15万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-25 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10491056
• 关键词: 16 year old; Address; Affect; Affective; Age; Alcohol-Related Neurodevelopmental Disorder; Arousal; Attenuated; Back; Behavioral; Case Study; Child; Clinical; Cognitive; Cohort Studies; Collaborations; Data; Development; Doctor of Medicine; Drowsiness; Emotional; Emotions; Environment; Equipment; Event; Fetal Alcohol Exposure; Fetal Alcohol Spectrum Disorder; Fetal Alcohol Syndrome; Fetal alcohol effects; Gold; Image; Impairment; Individual; Infant; Intervention; Interview; Investigation; Laboratories; Lead; Learning; Literature; Longitudinal cohort; Measurement; Measures; Mediating; Memory; Memory impairment; Methodology; Methods; Monitor; Mothers; Neurocognitive; Newborn Infant; Outcome; Participant; Pathway interactions; Pattern; Performance; Persons; Play; Polysomnography; Population; Post-Traumatic Stress Disorders; Pregnant Women; Prevalence; Procedures; Province; Psychophysiology; Public Health; REM Sleep; Reaction; Research; Rest; Role; Science; Short-Term Memory; Site; Sleep; Sleep Architecture; Sleep Disorders; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; South Africa; Stimulus; Testing; TimeLine; Universities; alcohol consumption during pregnancy; alcohol exposure; alcohol measurement; attenuation; base; biobehavior; cohort; emotion dysregulation; emotion regulation; epidemiology study; experience; eyeblink conditioning; infancy; innovation; memory consolidation; neuroimaging; novel; prospective; recruit; response; sleep onset; sleep pattern; standardize measure; young adult

ABSTRACT Prenatal alcohol exposure (PAE) is associated with a broad range of adverse and enduring consequences, including impaired learning and memory and altered responses to emotion-laden events (i.e., emotion dysregulation). Although sleep problems are often noted in epidemiological studies and clinical case reports relating to fetal alcohol spectrum disorders (FASD), they have not been well characterized using objective methodologies, such as polysomnography (PSG). Moreover, no studies have explored possible associations between sleep problems and memory and emotional regulation impairments in FASD. Investigation of these associations is warranted because healthy sleep is known to play a critical role in the consolidation of newly-acquired declarative memories and to attenuate emotional reactivity to affectively- valenced stimuli. The proposed study will be the first to investigate sleep architecture and its relation to memory consolidation and emotional regulation in FASD. 90 young adults (18-21 yr of age; 30 fetal alcohol syndrome (FAS) or partial FAS (PFAS), 30 non-syndromal heavily-exposed, and 30 non-exposed controls) will be recruited from PI Sandra Jacobson’s and Co-I Joseph Jacobson’s well-characterized Cape Town, South Africa, FASD cohort, which has been followed longitudinally since infancy. The data will be collected in PI Thomas’s Sleep Sciences Laboratory at the University of Cape Town. Cape Town is an excellent venue for this study given the unusually large number of individuals with heavy PAE and FAS available at a single site and the availability of a state-of-the-art PSG-equipped laboratory. Sleep data will be obtained over three consecutive nights. The 1st (adaptation) night will allow participants to acclimate to the sleep laboratory’s environment and to sleeping with monitoring equipment attached. Sleep on the 2nd night will be preceded by learning trials of standard declarative memory tests, which have been found to be affected by PAE, and will be followed in the morning by delayed recall trials. This procedure will allow us to examine associations between sleep disruption and memory consolidation. Sleep on the 3rd night will be preceded by initial viewing of valenced pictures and will be followed in the morning by viewing of the same stimuli. Psychophysiological measurement during both pre- and post-sleep viewing will allow us to examine associations between sleep disruption and affective arousal/emotion regulation. The aims are (1) to characterize sleep architecture of young adults with FASD; (2) to test the hypothesis that reductions in slow-wave sleep (SWS) percentage will mediate PAE-related disruptions in memory consolidation; and (3) to test the hypothesis that reductions in rapid eye movement (REM) sleep percentage will mediate PAE- related alterations in emotional reactivity to previously-viewed emotionally-valenced pictures. If the predicted associations are observed, sleep-based interventions may offer important and novel pathways for addressing deficits in declarative memory and emotion regulation in FASD.

抽象的 产前酒精暴露 (PAE) 与一系列不良和持久的后果有关， 包括学习和记忆受损以及对充满情绪的事件的反应改变（即情绪 尽管流行病学研究和临床病例中经常注意到睡眠问题。 与胎儿酒精谱系障碍 (FASD) 相关的报告，尚未通过使用对其进行很好的表征 此外，还没有研究探讨过客观方法，例如多导睡眠图（PSG）。 FASD 睡眠问题与记忆和情绪调节障碍之间的关联。 对这些关联的调查是有必要的，因为众所周知，健康的睡眠在 巩固新获得的陈述性记忆并减弱情感反应 拟议的研究将是第一个调查睡眠结构及其与睡眠结构的关系的研究。 FASD 的记忆巩固和情绪调节 90 名年轻人（18-21 岁；30 胎儿酒精） 综合征 (FAS) 或部分 FAS (PFAS)、30 名非综合征重度暴露者和 30 名非暴露对照） 将从 PI Sandra Jacobson 和 Co-I Joseph Jacobson 的特色开普敦招募， 南非，胎儿酒精谱系障碍 (FASD) 队列，从婴儿期起就进行纵向跟踪 数据将被收集。 开普敦大学 PI Thomas 睡眠科学实验室的博士是一个优秀的博士。 考虑到患有重度 PAE 和 FAS 的个体异常多，因此开展这项研究的地点 将获得单一站点和配备最先进 PSG 的实验室的可用性。 连续三个晚上，第一个（适应）晚上将让参与者适应睡眠。 实验室的环境以及第二天晚上睡觉时附有监控设备。 在标准陈述性记忆测试的学习试验之前，已发现这些测试受到以下因素的影响 PAE，随后将在早上进行延迟召回试验，该程序将使我们能够进行检查。 睡眠中断和记忆巩固之间的关联将在第三晚的睡眠之前进行。 最初观看带价图片，然后在早上观看相同的刺激。 睡前和睡后观看期间的心理生理测量将使我们能够检查 睡眠中断与情感唤醒/情绪调节之间的关联 目的是 (1) (2) 检验减少的假设 慢波睡眠 (SWS) 百分比将调节与 PAE 相关的记忆巩固中断；以及 (3) 测试快速眼动 (REM) 睡眠百分比的减少会介导 PAE 的假设 与之前观看的情绪化图片相关的情绪反应变化。 观察到预测的关联，基于睡眠的干预措施可能会提供重要而新颖的途径 解决 FASD 的陈述性记忆和情绪调节缺陷。