Life-course social adversity, pesticide exposure, and cognitive outcomes among an ongoing cohort of mid-life Latina women in an under served agricultural region

服务不足的农业地区一群中年拉丁裔女性的生命历程中的社会逆境、农药接触和认知结果

• 批准号: 10261507
• 负责人: Jacqueline Marie Torres
• 金额: $ 198.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261507
• 关键词: Adult; Aging; Agriculture; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Area; Biological Markers; Birth; Brain; California; Cardiovascular system; Child; Chronic; Cognitive; Cognitive aging; Data; Data Collection; Diabetes Mellitus; Disadvantaged; Disease; Elderly; Enrollment; Environmental Exposure; Environmental Risk Factor; Event; Exposure to; Face; Family; Geographic Information Systems; Goals; Health; Heterogeneity; High Prevalence; Home; Household; Individual; Inflammation; Inflammatory; Intervention; Latina; Latino; Life; Life Cycle Stages; Link; Literature; Low income; Magnetic Resonance Imaging; Measures; Mediating; Mexican Americans; Minority Groups; Mothers; National Institute of Environmental Health Sciences; Obesity; Occupations; Outcome; Participant; Pathology; Pattern; Pesticides; Population; Poverty; Presenile Alzheimer Dementia; Prevention; Recording of previous events; Reporting; Research; Risk Factors; Sampling; Shapes; Stress; Structure; Time; Variant; Woman; Work; agricultural community; agricultural pesticide; agricultural region; base; cardiometabolic risk; cardiometabolism; cognitive ability; cognitive performance; cognitive testing; cohort; data harmonization; dementia risk; experience; farm worker; follow-up; health assessment; inflammatory marker; innovation; member; middle age; migration; operation; pesticide exposure; prospective; social; social factors; white matter

Latinos are expected to represent 21% of US adults over 65 years by 2060, up from 8% in 2015. Compared to non-Latino whites, US Latinos have a higher prevalence and earlier onset of Alzheimer’s disease and related dementias (ADRDs) and face a higher burden of related risk factors (e.g. cardio-metabolic conditions). Life- course circumstances including social adversity and environmental exposures may shape within-group variation in ADRDs and related risk factors among US Latinos. Understanding the unique and combined impacts of social and environmental factors on mid-life cognitive outcomes is critical for informing early ADRDs prevention efforts; these exposures represent actionable targets for multi-level interventions. Nevertheless, there is limited research on the impact of social adversity and pesticide exposure on ADRDs risk, including among mid-life Latinos living in underserved agricultural areas with high pesticide exposure. In particular, few studies have prospectively evaluated the impacts of social adversity, including culturally-specific (e.g. migration-related) adversity on ADRDs among Latinos; most studies of pesticides and ADRDs rely on crude exposure measures (e.g. recall of life-time occupation). We have a unique opportunity to evaluate social and pesticide exposure in association with ADRDs risk factors among an ongoing cohort of approximately 550 mid-life Latina women (average 47 years) living in an underserved agricultural region. The Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study, initiated in 1998 as an NIEHS/EPA Children’s Center, is a well-established longitudinal birth cohort of low-income, Mexican American mother-child dyads living in a California agricultural community. Substantial information has been collected on mothers’ early and mid-life social adversity, mid-life cardio-metabolic health, and pesticide exposure captured via biomarkers and geographic information system-based residential proximity to pesticide applications. We aim to add two mid-life cognitive assessments, additional social adversity and pesticide exposure measures, and brain biomarker data collection (on a subset of 200). Informed by the life-course perspective and the exposure-stress-disease framework, which posits that social and environmental exposures may have unique and combined impacts on health, we propose to carry out the following Specific Aims: 1) To quantify associations between early and mid-life social adversity on cognitive performance among mid-life Latina women and the extent to which these associations are explained by cardio-metabolic and inflammatory mechanisms, 2) To estimate associations between agricultural pesticide exposure and cognitive performance and evaluate whether social adversity and pesticide exposure interact to produce poorer cognitive outcomes among mid-life Latina women, and 3) To evaluate relationships between life-course social adversity, pesticide exposure, and brain biomarkers among mid-life Latina women. Our overall goal is to inform early ADRDs prevention efforts among US Latinos -- the most rapidly growing aging minority group in the US.

预计到 2060 年，拉丁裔将占美国 65 岁以上成年人的 21%，高于 2015 年的 8%。 与非拉丁裔白人相比，美国拉丁裔阿尔茨海默病及相关疾病的患病率更高且发病更早 痴呆症（ADRD）并面临更高的相关风险因素负担（例如心脏代谢状况）。 包括社会逆境和环境暴露在内的课程环境可能会影响群体内部 了解美国拉丁裔的 ADRD 差异和相关风险因素。 社会和环境因素对中年认知结果的影响对于提供信息至关重要 早期 ADRD 预防工作；这些暴露代表了多层次的可行目标 然而，关于社会逆境和农药接触的影响的研究有限。 ADRD 风险，包括生活在农药含量高、服务欠缺的农业地区的中年拉丁美洲人 特别是，很少有研究前瞻性地评估社会逆境的影响，包括暴露。 拉丁裔中特定文化（例如与移民相关）的逆境对 ADRD 的影响；大多数研究涉及农药和 ADRD 依赖于粗略的暴露措施（例如，回忆一生的职业）。 在正在进行的队列中评估社会和农药暴露与 ADRD 风险因素的关系 大约 550 名中年拉丁裔女性（平均 47 岁）生活在服务不足的农业地区。 萨利纳斯母亲和儿童健康评估中心 (CHAMACOS) 研究于 1998 年启动 NIEHS/EPA 儿童中心是一个完善的纵向出生队列，由墨西哥低收入人群组成 生活在加州农业社区的美国母子二人组已获得大量信息。 收集了关于母亲早年和中年社会逆境、中年心脏代谢健康和农药的信息 通过生物标记物和基于地理信息系统的住宅邻近农药捕获的暴露情况 我们的目标是添加两项中年认知评估、额外的社会逆境和农药。 暴露测量和大脑生物标志物数据收集（200 个子集）。 观点和暴露-压力-疾病框架，该框架将社会和环境暴露定位为 可能对健康产生独特和综合的影响，我们建议实现以下具体目标： 1) 早年和中年社会逆境与中年认知表现之间的定量关联 拉丁裔女性以及这些关联在多大程度上可以通过心脏代谢和炎症来解释 机制，2) 估计农业农药接触与认知表现之间的关联 并评估社会逆境和农药接触是否相互作用会产生更差的结果 中年拉丁裔女性，以及 3) 评估生命历程中的社会逆境与农药之间的关系 我们的总体目标是为早期 ADRD 提供信息。 美国拉丁美洲人——美国增长最快的老龄化少数群体——的预防。