Gynecologic Biospecimen Pathology Core

妇科生物样本病理学核心

基本信息

批准号：
10488644
负责人：
Jian-Jun Wei
金额：
$ 16.72万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-17 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10488644
关键词：
Applications Grants Biological Markers Biological Specimen database Blood Body Fluids CLIA certified Chicago Clinical Clinical Trials Collection Communities Community Clinical Oncology Program Comprehensive Cancer Center Core Facility County DNA Data Development Ethnic Origin Evaluation Event Family Female Genital Neoplasms Formalin Freezing Genes Goals Gynecologic Histocytochemistry Histology Hospitals Human Immunohistochemistry Infrastructure Institutional Review Boards Investigation Malignant Female Reproductive System Neoplasm Malignant Neoplasms Manuals Minority Minority Groups Minority Health Research Molecular Normal tissue morphology Paraffin Embedding Pathologic Pathologist Pathology Population Principal Investigator Process Protocols documentation Public Hospitals RNA Race Recording of previous events Research Research Activity Research Personnel Research Project Grants Resource Sharing Resources Sampling Services Site Specimen Standardization Tissue Microarray Training and Education Translational Research Tumor Tissue Universities Work base biobank cancer health disparity clinical database community engaged research community engagement cooking digital pathology education research ethnic minority forging genetic testing health equity infrastructure development innovation meetings pathology imaging precision medicine programs racial and ethnic repository research and development support tools translational cancer research translational scientist tumor underserved minority

项目摘要

ABSTRACT The Robert H. Lurie Comprehensive Cancer Center (LCC) of Northwestern University has strongly endorsed and agreed to share its Pathology Core Facility (LCC PCF) with NU-CHERS investigators through the establishment of the NU-CHERS Gynecologic Biospecimen Pathology Shared Resource Core (GBPC) in furtherance of the overarching goal of the NU-CHERS P20 application to support innovative translational research to elucidate and eliminate a broad spectrum of gynecologic cancer disparities. The GBPC will maintain the NU-CHERS Community Gynecologic Biobanking Collection (CGBC), enhancing the LCC PCF biospecimen collection by procuring a robust and diverse collection of gynecologic cancer specimens from Chicago’s largest public hospital, the John H. Stroger Jr, Hospital of Cook County (SHCC). The Director of the LCC-PCF, Jian- Jun Wei, MD is Co-Director of the NU-CHERS GBPC, underscoring the commitment of the LCC PCF to the infrastructure development and translational research proposed in the NU-CHERS application to reduce gynecologic cancer disparities. Working in tandem with Dr. Wei is GBPC Co-Director, Thomas Lad, MD who is Principal Investigator of the SHCC’s Minority Underserved NCI Community Oncology Research Program. The GBPC has the following Specific Aims. Aim 1: Engage NU-CHERS affiliated site John H. Stroger Jr, Hospital of Cook County in developing the Community Gynecologic Biobanking Collection (CGBC) a comprehensive biorepository of well-defined gynecologic tumor types, paired with clinical and pathologic data, from racial/ethnic minority and reference populations. Aim 2: Provide research histology and pathology services to NU-CHERS investigations of molecular-based gynecologic cancer disparities in minority populations. Aim 3: Support clinical trials led by NU-CHERS investigators and aimed at minimizing molecular-based gynecologic cancer disparities in minority populations that require the analysis of correlative components. Aim 4: Expand community-engaged research capacity among NU-CHERS research project and DRP investigators through community-tailored, reciprocal education and training in the procurement of racial/ethnic minority biospecimen. Aim 5: Participate in ongoing evaluation and transition planning to develop GBPC into a full P50 SPORE shared resource core.

抽象的西北大学的Robert H. Lurie综合癌症中心（LCC）已得到强烈认可并同意通过在建立Nu-Chers妇科生物测试病理学共享资源核心（GBPC） Nu-Chers P20应用程序的总体目标的促进，以支持创新的翻译阐明和消除广泛的妇科癌症差异的研究。 GBPC将维持 Nu-Chers社区妇科生物群体（CGBC），增强了LCC PCF BiosSecimen 通过从芝加哥最大的最大的妇科癌症标本中采购强大而潜水的妇科癌标本来收集公立医院，库克县医院（SHCC）的约翰·H·斯特罗格（John H. Stroger Jr）。 LCC-PCF的主任Jian- 医学博士Jun Wei是Nu-Chers GBPC的联合主任，强调了LCC PCF的承诺 NU-CHERS应用中提出的基础设施开发和翻译研究以减少妇科癌症差异。与Wei博士同时合作是GBPC联合导演，医学博士托马斯·拉德（Thomas Lad） SHCC少数民族服务不足的NCI社区肿瘤研究计划的首席研究员。这 GBPC具有以下特定目标。 AIM 1：与Nu-Chers会员网站约翰·H·斯特罗格（John H. Stroger Jr Jr）接触库克县在开发社区妇科生物群集合（CGBC）中综合定义明确定义的妇科肿瘤类型的生物措施，并与临床和病理数据配对，来自种族/族裔少数群体和参考人群。目标2：向Nu-Chers提供研究组织学和病理学服务对少数族裔种群中基于分子的妇科癌症差异的研究。目标3：支持临床 NU-CHERS研究人员领导的试验旨在最大程度地减少基于分子的妇科癌症差异在需要分析正确组成部分的少数民族中。目标4：扩展社区参与 NU-CHERS研究项目和DRP调查人员之间的研究能力，通过社区守则，种族/族裔少数民族生物群体采购方面的互惠教育和培训。目标5：参加正在进行的评估和过渡计划将GBPC开发为完整的P50孢子共享资源核心。