To Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts

维护和丰富现有环境流行病学队列的资源基础设施

• 批准号: 10304867
• 负责人: Julie Beth Herbstman
• 金额: $ 38.26万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-02-15 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10304867
• 关键词: African American; Applications Grants; Aromatic Polycyclic Hydrocarbons; Award; Behavior; Biological; Biological Markers; Biological Specimen database; Birth; Chemicals; Child; Childhood; Cities; Collaborations; Collection; Color; Communication; Communities; Community Outreach; Consent; Data; Data Management Resources; Databases; Discipline; Disease; Education; Elements; Enrollment; Ensure; Environmental Epidemiology; Environmental Health; Environmental Pollutants; Equipment and supply inventories; Exposure to; Flame Retardants; Foundations; Funding; Gifts; Grant; Health; Health Resources; Infrastructure; Interdisciplinary Study; Laboratories; Latino; Letters; Low income; Magnetic Resonance Imaging; Measures; Methods; Mexico; Minority; Mitochondria; Mitochondrial DNA; Modeling; Molecular Epidemiology; Mothers; Newborn Infant; Outcome; Participant; Pesticides; Philanthropic Fund; Poison; Policies; Population; Pregnant Women; Preparation; Privatization; Psychologist; Quality Control; Research Personnel; Resources; Secure; Services; Siblings; Standardization; Students; Surveys; Technology; Teenagers; Toxic effect; Translations; Work; Youth; aged; base; biobank; bisphenol A; cohort; data management; environmental justice; environmental tobacco smoke; experience; health data; health record; high throughput screening; improved; in utero; insight; inter-institutional; medical schools; mental health counseling; neurodevelopment; new technology; novel; novel marker; outreach; oxidative damage; patient engagement; payment; phthalates; pollutant; polybrominated diphenyl ether; pregnant; prenatal environmental exposure; prenatal exposure; preservation; prevent; recruit; resource guides; screening program; student training; tool; training opportunity; user-friendly; volunteer

PROJECT SUMMARY: The Columbia Center for Children’s Environmental Health (CCCEH) requests support to maintain retention and engagement of its unique environmental cohorts, enhance basic laboratory and data management resources, increase community outreach, and set the stage for new partnerships and training opportunities to evaluate cumulative oxidative damage from prenatal exposure to mixtures of environmental pollutants. Currently, over 1,000 children are enrolled in the CCCEH cohorts, including the Mothers and Newborns cohort, the Sibling/Hermanos cohort, and the Fair Start cohort; we expect that we will have a total enrollment of 1,500 children by 2023. The CCCEH cohorts are comprised of mothers and children who are low income and minority (largely African-American and Latino). Therefore, it is of critical importance to retain these participants, their associated biorepositories, and the environmental health data they have provided through increased engagement activities, more laboratory resources, and enhanced data management, preparation, and sharing. Impressively, over the past 20 years, the Center has collected over 4,100,416 for 31,742 variables and 8,478 standardized derived variables. The exposures studied in these cohorts include diverse toxic pollutants and chemicals, including polycyclic aromatic hydrocarbons (PAH), phthalates, pesticides, bisphenol A (BPA), environmental tobacco smoke (ETS), and polybrominated diphenyl ethers (PBDE) flame retardants. The Center has also collected a wealth of outcome data from anthropometric measures, neurodevelopmental assessments, magnetic resonance imaging (MRI), and health records. The support will facilitate the Center’s outreach efforts to guide behaviors and inform policies to reduce exposures of pregnant women and children to toxic chemicals and pollutants. It will lay the groundwork for new collaborations across cohorts by incorporating novel biological measures that can provide new insight on the mechanisms of exposure-related disease. To develop a novel biomarker for assessing cumulative damage in mtDNA, the Center will integrate information from high-throughput screening programs (such as Tox21 and ToxCast™) to inform mixture models based on mitochondrial toxicity. The Center will also develop a new inter-institutional collaboration with Mount Sinai School of Medicine that will compare mtDNA measures in our CCCEH cohorts with the same measures in their birth cohort from Mexico City. Given the urgent need to prevent environmentally related diseases and neurodevelopment disorders in children, strong infrastructure support is warranted to maintain and preserve our Center’s unique resources, prepare for future research directions, and ensure effective communication of our findings.

项目摘要： 哥伦比亚儿童环境健康中心（CCCEH）请求支持保留和 参与其独特的环境人群，增强基本实验室和数据管理资源， 增加社区宣传，并为新的合作伙伴关系和培训机会奠定了基础 产前暴露于环境污染物混合的累积氧化物损害。目前，结束 1,000名儿童参加了CCCEH队列，包括母亲和新生儿队员， 兄弟姐妹/Hermanos队列和公平的开始队列；我们预计我们的总入学人数为1,500 到2023年，儿童。CCCEH队列由低收入和少数族裔的母亲和儿童组成 （主要是非裔美国人和拉丁裔）。因此，保留这些参与者，他们的 相关的生物库以及通过增加提供的环境健康数据 参与活动，更多的实验室资源以及增强数据管理，准备和共享。 令人印象深刻的是，在过去的20年中，该中心收集了31,742个变量和8,478的4,100,416 标准化的派生变量。这些队列中研究的暴露包括潜水员有毒污染物和 化学物质，包括多环芳烃（PAH），邻苯二甲酸盐，农药，双酚A（BPA）， 环境烟草烟雾（ETS）和多溴二苯基醚（PBDE）阻燃剂。中心 还从人体测量值，神经发育评估中收集了大量结果数据， 磁共振成像（MRI）和健康记录。支持将促进中心的外展工作 指导行为并告知政策以减少孕妇和儿童的暴露 和污染物。它将通过结合新颖的生物学来为各个队列的新合作奠定基础 可以提供有关暴露相关疾病机制的新见解的措施。发展小说 生物标志物用于评估mtDNA累积损害的生物标志物，该中心将整合来自高通量的信息 筛选程序（例如TOX21和TOXCAST™），以基于线粒体毒性的混合模型告知混合模型。 该中心还将与西奈山医学院建立新的机构间合作 比较我们CCCEH队列中的mtDNA测量值与从墨西哥出生队列中的相同测量值进行比较 城市。考虑到迫切需要防止与环境相关的疾病和神经发育障碍 儿童，有必要提供强大的基础设施支持，以维护和保留我们中心的独特资源， 为将来的研究方向做准备，并确保我们的发现有效沟通。