Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application)

芝加哥肌肉骨骼疼痛中心 (C-COMP)（整体申请）

• 批准号: 10488591
• 负责人: Anne-Marie Malfait
• 金额: $ 77.01万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488591
• 关键词: Address; Adverse effects; Affect; Analgesics; Animal Model; Area; Arthritis; Behavioral; Behavioral Assay; Bioinformatics; Chicago; Chronic; Clinical; Communication; Communities; Consultations; Custom; Disease; Electrophysiology (science); Environment; Equipment; Fostering; Funding; Geography; Goals; Grant; Human; Infrastructure; Interdisciplinary Study; Investigation; Knowledge; Leadership; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal Pain; Musculoskeletal System; Neurobiology; Neurosciences; Non-Steroidal Anti-Inflammatory Agents; Opioid; Pain; Pain Research; Patients; Pharmaceutical Preparations; Physiology; Population; Postdoctoral Fellow; Protocols documentation; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Rheumatism; Scientist; Services; Source; Techniques; Technology; Testing; Time; Tissues; Training; Training and Education; Translational Research; Translations; base; behavior test; career; chronic musculoskeletal pain; chronic pain; collaborative environment; disability; in vivo calcium imaging; innovation; multidisciplinary; neuronal circuitry; new therapeutic target; novel; novel therapeutic intervention; novel therapeutics; opioid abuse; optogenetics; outreach; pain relief; prevent; programs; side effect; testing access; transcriptomics; web site

Project summary We seek to establish a new resource-based Center to foster and support research and training aimed at understanding the mechanisms underlying pain associated with musculoskeletal (MSK) and rheumatic diseases, with the ultimate goal of better managing and preventing it. One third of the world’s population is affected by chronic pain, and the MSK system is the most prevalent source of pain and disability. Currently available analgesic drugs act on a limited number of targets, and they do not provide sustained pain relief and their chronic use is associated with serious adverse effects. One of the major obstacles in identifying safe and efficacious drugs for producing pain relief is our general lack of understanding of the mechanisms underlying MSK pain, and how these mechanisms may overlap or differ between different types of rheumatic and MSK diseases. The Chicago Center on Musculoskeletal Pain (C-COMP) will address this need in a timely and unique manner, capitalizing on the world class expertise that is available to us in the areas of MSK research, pain and neurobiology to achieve the following broad long-term goals: (1) To integrate basic, translational and clinical expertise in a multidisciplinary Center which will provide the leadership and resources for promoting MSK pain research; (2) To enhance the research environment for the MSK research community by providing access to world-class expertise and state-of-the-art resources, technologies, and infrastructure for studying pain; (3) To promote interdisciplinary research between the MSK research field and the field of pain/neuroscience; (4) To expand the MSK pain research community by attracting early career as well as established researchers into this area of study. We envision three Cores operating in support of these overall goals. The Administrative Core A (PI: A.M. Malfait; co-director: J.J. Jacobs) will provide leadership, maintain effective communication, partner with related Centers to stimulate human translation of findings, and implement a dynamic enrichment program. The Behavioral Resource Core B (PI: R.E. Miller; co-director: D.R. Sumner) will provide a centralized resource to facilitate behavioral assays in a broad array of animal models of rheumatic and MSK diseases, including training for behavioral tests, access to customized protocols, equipment, and space to perform testing, a consultation service and a customized, full-service option for behavioral testing. The Neurobiology Core C (PI: RJ Miller; co- director: D.R. Sumner) will offer state-of-the-art techniques for assessment and manipulation of neuronal circuitry involved in pain physiology, such as in vivo calcium imaging, electrophysiology, chemo/optogenetics, transcriptomics/bioinformatics and neuroanatomical techniques. This will allow the Center’s research community to engage in cutting-edge investigations of the mechanisms of pain in animal models of MSK disease. In summary, C-COMP will provide (1) unique resources and infrastructure for supporting high-quality externally funded research and (2) pilot funding, education, and training in a multidisciplinary and collaborative fashion. This integrated approach is expected to accelerate research in pain associated with MSK and rheumatic disease.

项目摘要 我们试图建立一个新的基于资源的中心，以培养和支持针对的研究和培训 了解与肌肉骨骼（MSK）和风湿性疾病有关的机制， 以更好地管理和防止它的最终目标。世界三分之一的人口受到 慢性疼痛，MSK系统是疼痛和残疾的最普遍来源。目前可用 镇痛药对有限数量的靶标作用，并且不能提供持续的疼痛缓解且慢性 使用与严重的不利影响有关。确定安全有效的主要障碍之一 产生疼痛的药物是我们普遍缺乏对MSK疼痛的机制的了解，并且 这些机制如何重叠或不同类型的风湿病和MSK疾病之间的重叠或不同。这 芝加哥肌肉骨骼疼痛（C-COMP）的中心将及时解决这种需求， 在MSK研究，痛苦和 神经生物学实现以下广泛的长期目标：（1）整合基本，翻译和临床 多学科中心的专业知识，该中心将为促进MSK痛苦提供领导和资源 研究; （2）通过提供访问权限来增强MSK研究社区的研究环境 世界一流的专业知识以及研究疼痛的最先进资源，技术和基础设施； （3）到 促进MSK研究领域与疼痛/神经科学领域之间的跨学科研究； （4）至 通过吸引早期职业以及既定的研究人员来扩大MSK疼痛研究社区 研究领域。我们设想三个核心以支持这些总体目标。行政核心A （PI：A.M。MALFAIT；联合导演：J.J。Jacobs）将提供领导才能，保持有效的沟通，与 相关中心刺激人类的发现，并实施动态富集计划。这 行为资源核心B（PI：R.E. Miller；联合导演：D.R. Sumner）将为集中资源提供 在各种风湿性和MSK疾病的动物模型中促进行为分析，包括训练 对于行为测试，访问自定义协议，设备和执行测试的空间，咨询 服务和行为测试的自定义全方位服务选项。神经生物学核心C（PI：RJ Miller；共同 主任：D.R。 Sumner）将提供用于评估和操纵神经元电路的最新技术 参与疼痛生理学，例如体内钙成像，电生理学，化学/光遗传学， 转录组学/生物信息学和神经解剖技术。这将允许该中心的研究社区 参与MSK疾病动物模型中疼痛机制的尖端研究。在 摘要，C-Comp将提供（1）独特的资源和基础架构，以支持外部高质量 资助研究以及（2）以多学科和协作方式进行了试点资金，教育和培训。 这种综合方法有望加速与MSK和风湿病有关的疼痛研究。